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Transmission disequilibrium tests confirm the link between DRD4 gene polymorphism and infant attachment.
. 2005 Jan 05; 132B(1):126-30.

Abstract

Following up the results of a previous population association study (Lakatos et al. [2000: Mol Psychiatry 5:633-637; Lakatos et al. [2002: Mol Psychiatry 7:27-31]) by analyses based on parental genetic data confirmed the link between infant attachment and the dopamine D4 receptor (DRD4) gene. Extended transmission disequilibrium tests (ETDT) were performed to determine whether biased transmission of exon III 48 basepair repeat alleles occurred to infants displaying disorganized and secure attachment behavior with their mothers. The overall allele-wise TDTs were significant for both groups (P = 0.038 and 0.020, respectively): a trend for preferential transmission of the seven-repeat allele to disorganized infants was observed (TDT(chi)(2) = 3.27, df = 1, P = 0.071), and there was a significant non-transmission of the same allele to securely attached infants (TDT(chi)(2) = 6.00, df = 1, P = 0.014). Analysis of haplotypes of the exon III repeat and the -521 C/T promoter polymorphisms in family trios showed that the transmission bias in the larger secure group was due to the low-rate transmission of the T.7 haplotype containing both the seven-repeat and the -521 T alleles (TDT(chi)(2) = 4.46, df = 1, P = 0.035). This suggests that not carrying the T.7 haplotype of the DRD4 gene may act as a resilience factor in the optimal development of early attachment.

Authors+Show Affiliations

Social Development Group, Institute for Psychology of the Hungarian Academy of Sciences, P.O. Box 398, Budapest, 1394 Hungary. gervju@mtapi.huNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15690552

Citation

Gervai, Judit, et al. "Transmission Disequilibrium Tests Confirm the Link Between DRD4 Gene Polymorphism and Infant Attachment." American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, vol. 132B, no. 1, 2005, pp. 126-30.
Gervai J, Nemoda Z, Lakatos K, et al. Transmission disequilibrium tests confirm the link between DRD4 gene polymorphism and infant attachment. Am J Med Genet B Neuropsychiatr Genet. 2005;132B(1):126-30.
Gervai, J., Nemoda, Z., Lakatos, K., Ronai, Z., Toth, I., Ney, K., & Sasvari-Szekely, M. (2005). Transmission disequilibrium tests confirm the link between DRD4 gene polymorphism and infant attachment. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, 132B(1), 126-30.
Gervai J, et al. Transmission Disequilibrium Tests Confirm the Link Between DRD4 Gene Polymorphism and Infant Attachment. Am J Med Genet B Neuropsychiatr Genet. 2005 Jan 5;132B(1):126-30. PubMed PMID: 15690552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transmission disequilibrium tests confirm the link between DRD4 gene polymorphism and infant attachment. AU - Gervai,Judit, AU - Nemoda,Zsofia, AU - Lakatos,Krisztina, AU - Ronai,Zsolt, AU - Toth,Ildiko, AU - Ney,Krisztina, AU - Sasvari-Szekely,Maria, PY - 2005/2/4/pubmed PY - 2005/5/13/medline PY - 2005/2/4/entrez SP - 126 EP - 30 JF - American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics JO - Am. J. Med. Genet. B Neuropsychiatr. Genet. VL - 132B IS - 1 N2 - Following up the results of a previous population association study (Lakatos et al. [2000: Mol Psychiatry 5:633-637; Lakatos et al. [2002: Mol Psychiatry 7:27-31]) by analyses based on parental genetic data confirmed the link between infant attachment and the dopamine D4 receptor (DRD4) gene. Extended transmission disequilibrium tests (ETDT) were performed to determine whether biased transmission of exon III 48 basepair repeat alleles occurred to infants displaying disorganized and secure attachment behavior with their mothers. The overall allele-wise TDTs were significant for both groups (P = 0.038 and 0.020, respectively): a trend for preferential transmission of the seven-repeat allele to disorganized infants was observed (TDT(chi)(2) = 3.27, df = 1, P = 0.071), and there was a significant non-transmission of the same allele to securely attached infants (TDT(chi)(2) = 6.00, df = 1, P = 0.014). Analysis of haplotypes of the exon III repeat and the -521 C/T promoter polymorphisms in family trios showed that the transmission bias in the larger secure group was due to the low-rate transmission of the T.7 haplotype containing both the seven-repeat and the -521 T alleles (TDT(chi)(2) = 4.46, df = 1, P = 0.035). This suggests that not carrying the T.7 haplotype of the DRD4 gene may act as a resilience factor in the optimal development of early attachment. SN - 1552-4841 UR - https://www.unboundmedicine.com/medline/citation/15690552/Transmission_disequilibrium_tests_confirm_the_link_between_DRD4_gene_polymorphism_and_infant_attachment_ L2 - https://doi.org/10.1002/ajmg.b.30102 DB - PRIME DP - Unbound Medicine ER -