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[Serum soluble adhesion molecules--sICAM-1, sVCAM-1, sE-selectin--in patients with systemic rheumatoid arthritis].
Pol Merkur Lekarski 2004; 17(100):353-6PM

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease characterised by chronic inflammation of the joints and is often associated with internal organs involvement. Cell adhesion molecules play an important role in the pathogenesis of endothelial-leukocyte interactions, angiogenesis and lymphocyte activation, leading to the progression of the disease. The objective of this study was to investigate whether the serum profile of soluble adhesion molecules is associated with clinical feature and extra-articular manifestation of RA.

MATERIAL AND METHODS

Serum levels of soluble intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1) and E-selectin (sE-selectin) were assessed by ELISA in 29 patients with RA and 25 healthy controls. Ten out of the 29 patients had systemic lesions.

RESULTS

The serum concentrations of siCAM-1, sVCAM-1, sE-selectin were significantly increased in RA patients compared with controls (p<0.001 in all cases). RA patients with extra-articular involvement showed significantly higher levels of sICAM-1 and sVCAM-1 than those without organ injury (p<0.001 and p<0.01 respectively). The serum concentrations of sICAM-1 and sVCAM-1 correlated with CRP and ESR.

CONCLUSIONS

We conclude that serum levels of sICAM-1 and sVCAM-1 may be useful in the diagnosis of the systemic injury in RA patients.

Authors+Show Affiliations

Klinika Reumatologii i Chorób Wewnetrznych Akademii Medycznej w Bialymstoku. klimp@amb.edu.plNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

pol

PubMed ID

15690700

Citation

Kuryliszyn-Moskal, Anna, et al. "[Serum Soluble Adhesion molecules--sICAM-1, sVCAM-1, sE-selectin--in Patients With Systemic Rheumatoid Arthritis]." Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, vol. 17, no. 100, 2004, pp. 353-6.
Kuryliszyn-Moskal A, Klimiuk PA, Sierakowski S. [Serum soluble adhesion molecules--sICAM-1, sVCAM-1, sE-selectin--in patients with systemic rheumatoid arthritis]. Pol Merkur Lekarski. 2004;17(100):353-6.
Kuryliszyn-Moskal, A., Klimiuk, P. A., & Sierakowski, S. (2004). [Serum soluble adhesion molecules--sICAM-1, sVCAM-1, sE-selectin--in patients with systemic rheumatoid arthritis]. Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, 17(100), pp. 353-6.
Kuryliszyn-Moskal A, Klimiuk PA, Sierakowski S. [Serum Soluble Adhesion molecules--sICAM-1, sVCAM-1, sE-selectin--in Patients With Systemic Rheumatoid Arthritis]. Pol Merkur Lekarski. 2004;17(100):353-6. PubMed PMID: 15690700.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Serum soluble adhesion molecules--sICAM-1, sVCAM-1, sE-selectin--in patients with systemic rheumatoid arthritis]. AU - Kuryliszyn-Moskal,Anna, AU - Klimiuk,Piotr A, AU - Sierakowski,Stanisław, PY - 2005/2/5/pubmed PY - 2005/4/22/medline PY - 2005/2/5/entrez SP - 353 EP - 6 JF - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego JO - Pol. Merkur. Lekarski VL - 17 IS - 100 N2 - UNLABELLED: Rheumatoid arthritis (RA) is an autoimmune disease characterised by chronic inflammation of the joints and is often associated with internal organs involvement. Cell adhesion molecules play an important role in the pathogenesis of endothelial-leukocyte interactions, angiogenesis and lymphocyte activation, leading to the progression of the disease. The objective of this study was to investigate whether the serum profile of soluble adhesion molecules is associated with clinical feature and extra-articular manifestation of RA. MATERIAL AND METHODS: Serum levels of soluble intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1) and E-selectin (sE-selectin) were assessed by ELISA in 29 patients with RA and 25 healthy controls. Ten out of the 29 patients had systemic lesions. RESULTS: The serum concentrations of siCAM-1, sVCAM-1, sE-selectin were significantly increased in RA patients compared with controls (p<0.001 in all cases). RA patients with extra-articular involvement showed significantly higher levels of sICAM-1 and sVCAM-1 than those without organ injury (p<0.001 and p<0.01 respectively). The serum concentrations of sICAM-1 and sVCAM-1 correlated with CRP and ESR. CONCLUSIONS: We conclude that serum levels of sICAM-1 and sVCAM-1 may be useful in the diagnosis of the systemic injury in RA patients. SN - 1426-9686 UR - https://www.unboundmedicine.com/medline/citation/15690700/[Serum_soluble_adhesion_molecules__sICAM_1_sVCAM_1_sE_selectin__in_patients_with_systemic_rheumatoid_arthritis]_ L2 - http://www.diseaseinfosearch.org/result/592 DB - PRIME DP - Unbound Medicine ER -