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Association of Helicobacter pylori-related distal gastric cancer with the HLA class II gene DQB10602 and cagA strains in a southern European population.
Helicobacter 2005; 10(1):12-21H

Abstract

BACKGROUND

Distinct human leukocyte antigen (HLA)-DQ genes have been associated with an increased or reduced risk for gastric cancer, but its association with Helicobacter pylori status is controversial. In the present study we evaluated the influence of host HLA DQA1 and DQB1 loci, H. pylori genotype, and socio-economic factors on predicting H. pylori-associated distal gastric cancer in a southern European population.

MATERIAL AND METHODS

In a prospective case-control (1 : 2) study, 42 patients with H. pylori-associated distal gastric cancer were matched by age (+/-5 years) and gender to 84 patients with H. pylori-associated benign gastroduodenal disease (controls). The level of education received, smoking status, alcohol consumption, origin and familial history of gastric cancer were registered at inclusion. HLA DQA1 and DQB1 typing and H. pylori genotyping were determined from endoscopic gastric mucosal biopsies.

RESULTS

Compared with control patients, a positive association with cagA(+) strains (p < .002) and a negative association with vacA-s2 strains (p < .02) was found in patients with distal gastric cancer. At the DQB1 locus, the (*)0602 allele was more frequent in distal gastric cancer than in controls (26.2% vs. 4.8%; p < .005). After correction for multiple comparisons (exact multiple regression analysis) the cagA(+) status and the DQB1(*)0602 allele were associated with an increased distal gastric cancer risk (OR 3.7; 95% CI = 1.33-12.26 and OR 4.82; 95% CI = 1.24-19.83, respectively) whereas the vacA-s2 status was associated with a decreased risk (OR 0.33; 95% CI = 0.10-0.94).

CONCLUSION

Our findings suggest that in the H. pylori-infected southern European population, the cagA genotype and the HLA-DQB1(*)0602 gene confer an increased risk for distal gastric cancer.

Authors+Show Affiliations

Gastroenterology Department, University Hospital of the Canary Islands, Spain. equinter@doymanet.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15691311

Citation

Quintero, Enrique, et al. "Association of Helicobacter Pylori-related Distal Gastric Cancer With the HLA Class II Gene DQB10602 and cagA Strains in a Southern European Population." Helicobacter, vol. 10, no. 1, 2005, pp. 12-21.
Quintero E, Pizarro MA, Rodrigo L, et al. Association of Helicobacter pylori-related distal gastric cancer with the HLA class II gene DQB10602 and cagA strains in a southern European population. Helicobacter. 2005;10(1):12-21.
Quintero, E., Pizarro, M. A., Rodrigo, L., Piqué, J. M., Lanas, A., Ponce, J., ... Salido, E. (2005). Association of Helicobacter pylori-related distal gastric cancer with the HLA class II gene DQB10602 and cagA strains in a southern European population. Helicobacter, 10(1), pp. 12-21.
Quintero E, et al. Association of Helicobacter Pylori-related Distal Gastric Cancer With the HLA Class II Gene DQB10602 and cagA Strains in a Southern European Population. Helicobacter. 2005;10(1):12-21. PubMed PMID: 15691311.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of Helicobacter pylori-related distal gastric cancer with the HLA class II gene DQB10602 and cagA strains in a southern European population. AU - Quintero,Enrique, AU - Pizarro,M Angeles, AU - Rodrigo,Luis, AU - Piqué,Josep M, AU - Lanas,Angel, AU - Ponce,Julio, AU - Miño,Gonzalo, AU - Gisbert,Javier, AU - Jurado,Aurora, AU - Herrero,M José, AU - Jiménez,Alejandro, AU - Torrado,Julio, AU - Ponte,Ana, AU - Díaz-de-Rojas,Francisco, AU - Salido,Eduardo, PY - 2005/2/5/pubmed PY - 2005/4/29/medline PY - 2005/2/5/entrez SP - 12 EP - 21 JF - Helicobacter JO - Helicobacter VL - 10 IS - 1 N2 - BACKGROUND: Distinct human leukocyte antigen (HLA)-DQ genes have been associated with an increased or reduced risk for gastric cancer, but its association with Helicobacter pylori status is controversial. In the present study we evaluated the influence of host HLA DQA1 and DQB1 loci, H. pylori genotype, and socio-economic factors on predicting H. pylori-associated distal gastric cancer in a southern European population. MATERIAL AND METHODS: In a prospective case-control (1 : 2) study, 42 patients with H. pylori-associated distal gastric cancer were matched by age (+/-5 years) and gender to 84 patients with H. pylori-associated benign gastroduodenal disease (controls). The level of education received, smoking status, alcohol consumption, origin and familial history of gastric cancer were registered at inclusion. HLA DQA1 and DQB1 typing and H. pylori genotyping were determined from endoscopic gastric mucosal biopsies. RESULTS: Compared with control patients, a positive association with cagA(+) strains (p < .002) and a negative association with vacA-s2 strains (p < .02) was found in patients with distal gastric cancer. At the DQB1 locus, the (*)0602 allele was more frequent in distal gastric cancer than in controls (26.2% vs. 4.8%; p < .005). After correction for multiple comparisons (exact multiple regression analysis) the cagA(+) status and the DQB1(*)0602 allele were associated with an increased distal gastric cancer risk (OR 3.7; 95% CI = 1.33-12.26 and OR 4.82; 95% CI = 1.24-19.83, respectively) whereas the vacA-s2 status was associated with a decreased risk (OR 0.33; 95% CI = 0.10-0.94). CONCLUSION: Our findings suggest that in the H. pylori-infected southern European population, the cagA genotype and the HLA-DQB1(*)0602 gene confer an increased risk for distal gastric cancer. SN - 1083-4389 UR - https://www.unboundmedicine.com/medline/citation/15691311/Association_of_Helicobacter_pylori_related_distal_gastric_cancer_with_the_HLA_class_II_gene_DQB10602_and_cagA_strains_in_a_southern_European_population_ L2 - https://doi.org/10.1111/j.1523-5378.2005.00287.x DB - PRIME DP - Unbound Medicine ER -