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Gastroduodenal lesions and Helicobacter pylori infection in dyspeptic patients with and without chronic renal failure.
Helicobacter. 2005 Feb; 10(1):53-8.H

Abstract

BACKGROUND

Patients with chronic renal failure (CRF) often have dyspeptic symptoms and may develop peptic disease or digestive disorders leading to severe gastrointestinal complications. The primary aim of this study was to evaluate the prevalence of peptic lesions and Helicobacter pylori infection, and the severity of dyspeptic symptoms, in dyspeptic patients with and without CRF. Our secondary aim was to investigate whether uremic status may affect the diagnostic efficiency of the [13]C-urea breath test ([13]C-UBT).

PATIENTS AND METHODS

We consecutively enrolled in the study 50 dyspeptic patients with chronic kidney failure (mean age 52 +/- 5 years), of whom 11 were on hemodialysis treatment (HD), and 93 subjects (mean age 54 +/- 7 years) with chronic dyspepsia and normal renal function (NRF). All patients completed an oriented and validated questionnaire scoring the severity of nine dyspeptic symptoms (i.e. epigastric pain, epigastric burning, postprandial fullness, early satiety, bloating, belching, nausea and vomiting) and underwent upper endoscopy with multiple bioptic sampling for rapid urease test and histological examination, [13]C-UBT and HpSA test.

RESULTS

The prevalences of peptic lesions and H. pylori infection and mean symptom score were 74%, 52% and 3.5 +/- 3, respectively, in dyspeptic patients with CRF and 18%, 36% and 8 +/- 5, respectively, in dyspeptic patients with NRF. The diagnostic accuracy of [13]C-UBT with respect to histological diagnosis was 94% and 97% for dyspeptic patients with and without renal failure, respectively.

CONCLUSIONS

1, A high frequency of peptic lesions and low symptom scores were observed in uremic patients in spite of H. pylori infection; 2, uremic status did not affect the diagnostic accuracy of [13]C-UBT.

Authors+Show Affiliations

Department of Clinical and Experimental Medicine, Gastroenterology Unit, University Federico II, Via Pansini n degree 580131 Naples, Italy. nardone@unina.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15691315

Citation

Nardone, Gerardo, et al. "Gastroduodenal Lesions and Helicobacter Pylori Infection in Dyspeptic Patients With and Without Chronic Renal Failure." Helicobacter, vol. 10, no. 1, 2005, pp. 53-8.
Nardone G, Rocco A, Fiorillo M, et al. Gastroduodenal lesions and Helicobacter pylori infection in dyspeptic patients with and without chronic renal failure. Helicobacter. 2005;10(1):53-8.
Nardone, G., Rocco, A., Fiorillo, M., Del Pezzo, M., Autiero, G., Cuomo, R., Sarnelli, G., Lambiase, A., Budillon, G., & Cianciaruso, B. (2005). Gastroduodenal lesions and Helicobacter pylori infection in dyspeptic patients with and without chronic renal failure. Helicobacter, 10(1), 53-8.
Nardone G, et al. Gastroduodenal Lesions and Helicobacter Pylori Infection in Dyspeptic Patients With and Without Chronic Renal Failure. Helicobacter. 2005;10(1):53-8. PubMed PMID: 15691315.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastroduodenal lesions and Helicobacter pylori infection in dyspeptic patients with and without chronic renal failure. AU - Nardone,Gerardo, AU - Rocco,Alba, AU - Fiorillo,Maria, AU - Del Pezzo,Mariassunta, AU - Autiero,Giovanni, AU - Cuomo,Rosario, AU - Sarnelli,Giovanni, AU - Lambiase,Antonietta, AU - Budillon,Gabriele, AU - Cianciaruso,Bruno, PY - 2005/2/5/pubmed PY - 2005/4/29/medline PY - 2005/2/5/entrez SP - 53 EP - 8 JF - Helicobacter JO - Helicobacter VL - 10 IS - 1 N2 - BACKGROUND: Patients with chronic renal failure (CRF) often have dyspeptic symptoms and may develop peptic disease or digestive disorders leading to severe gastrointestinal complications. The primary aim of this study was to evaluate the prevalence of peptic lesions and Helicobacter pylori infection, and the severity of dyspeptic symptoms, in dyspeptic patients with and without CRF. Our secondary aim was to investigate whether uremic status may affect the diagnostic efficiency of the [13]C-urea breath test ([13]C-UBT). PATIENTS AND METHODS: We consecutively enrolled in the study 50 dyspeptic patients with chronic kidney failure (mean age 52 +/- 5 years), of whom 11 were on hemodialysis treatment (HD), and 93 subjects (mean age 54 +/- 7 years) with chronic dyspepsia and normal renal function (NRF). All patients completed an oriented and validated questionnaire scoring the severity of nine dyspeptic symptoms (i.e. epigastric pain, epigastric burning, postprandial fullness, early satiety, bloating, belching, nausea and vomiting) and underwent upper endoscopy with multiple bioptic sampling for rapid urease test and histological examination, [13]C-UBT and HpSA test. RESULTS: The prevalences of peptic lesions and H. pylori infection and mean symptom score were 74%, 52% and 3.5 +/- 3, respectively, in dyspeptic patients with CRF and 18%, 36% and 8 +/- 5, respectively, in dyspeptic patients with NRF. The diagnostic accuracy of [13]C-UBT with respect to histological diagnosis was 94% and 97% for dyspeptic patients with and without renal failure, respectively. CONCLUSIONS: 1, A high frequency of peptic lesions and low symptom scores were observed in uremic patients in spite of H. pylori infection; 2, uremic status did not affect the diagnostic accuracy of [13]C-UBT. SN - 1083-4389 UR - https://www.unboundmedicine.com/medline/citation/15691315/Gastroduodenal_lesions_and_Helicobacter_pylori_infection_in_dyspeptic_patients_with_and_without_chronic_renal_failure_ DB - PRIME DP - Unbound Medicine ER -