Tags

Type your tag names separated by a space and hit enter

Is renal impairment a predictor of the incidence of cataract or cataract surgery? Findings from a population-based study.
Ophthalmology 2005; 112(2):293-300O

Abstract

PURPOSE

To explore the relationship between creatinine clearance, an estimate of glomerular filtration rate, and 5-year incidence of cataract and cataract surgery.

DESIGN

Population-based cohort study.

PARTICIPANTS

Of the 3654 participants (aged 49 years or older) of the Blue Mountains Eye Study (BMES I) baseline examination (during 1992 to 1994), 2334 (75%) were reexamined after 5 years from 1997 to 1999 (BMES II).

METHOD

Risk factor data were collected for all participants at baseline (BMES I). Assessment of renal function was based on estimated creatinine clearance (C(Cr)) calculated with the Cockcroft-Gault formula, adjusted for body surface area, and expressed in ml/minute/1.73 m2. Cataract incidence was determined from graded photographs. The association between renal function and incidence of cataract and cataract surgery was analyzed by logistic regression.

MAIN OUTCOME MEASURES

Incidence of nuclear, cortical, and posterior subcapsular cataract, and cataract surgery.

RESULTS

Mean C(Cr) +/- standard deviation was 60+/-13 ml/minute/1.73 m2. The overall 5-year incidence of nuclear, cortical, and posterior subcapsular cataract was 35.7% (417 of 1167 participants at risk), 16.7% (274 of 1641), and 4.3% (77 of 1790), respectively. Cataract surgery was performed in 6.8% (144 of 2123) of participants. There were no significant associations of renal function with incident nuclear (odds ratio [OR], 1.0; 95% confidence interval [CI], 0.99-1.02), cortical (OR, 1.0; CI, 0.98-1.01), and posterior subcapsular cataract (OR, 1.0; CI, 0.99-1.04) after adjusting for multiple risk factors. After adjusting for age, gender, and dark brown iris color, moderate or worse renal impairment (C(Cr) <60 ml/minute/1.73 m2) compared with normal or mildly impaired function (C(Cr) > or =60 ml/minute/1.73 m2) was significantly associated with incident cataract surgery (P<0.05), but the effect depended on age. Participants younger than 60 years of age with moderate to severe renal impairment had increased odds of incident cataract surgery (OR, 2.75; CI, 1.06-7.14), but this OR decreased with age. In participants 80 years old or older, the OR was 0.34 (CI, 0.11-1.10).

CONCLUSIONS

There were no significant effects of renal function on the incidence of cataract of any type. The effect of moderate or worse renal impairment on incident cataract surgery depended on age. However, the interpretation of this effect is uncertain because of additional factors that may be involved in patients having surgery.

Authors+Show Affiliations

Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, NSW, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15691566

Citation

Huynh, Son C., et al. "Is Renal Impairment a Predictor of the Incidence of Cataract or Cataract Surgery? Findings From a Population-based Study." Ophthalmology, vol. 112, no. 2, 2005, pp. 293-300.
Huynh SC, Kifley A, Strippoli GF, et al. Is renal impairment a predictor of the incidence of cataract or cataract surgery? Findings from a population-based study. Ophthalmology. 2005;112(2):293-300.
Huynh, S. C., Kifley, A., Strippoli, G. F., & Mitchell, P. (2005). Is renal impairment a predictor of the incidence of cataract or cataract surgery? Findings from a population-based study. Ophthalmology, 112(2), pp. 293-300.
Huynh SC, et al. Is Renal Impairment a Predictor of the Incidence of Cataract or Cataract Surgery? Findings From a Population-based Study. Ophthalmology. 2005;112(2):293-300. PubMed PMID: 15691566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is renal impairment a predictor of the incidence of cataract or cataract surgery? Findings from a population-based study. AU - Huynh,Son C, AU - Kifley,Annette, AU - Strippoli,Giovanni F M, AU - Mitchell,Paul, PY - 2004/06/18/received PY - 2004/09/02/accepted PY - 2005/2/5/pubmed PY - 2005/2/17/medline PY - 2005/2/5/entrez SP - 293 EP - 300 JF - Ophthalmology JO - Ophthalmology VL - 112 IS - 2 N2 - PURPOSE: To explore the relationship between creatinine clearance, an estimate of glomerular filtration rate, and 5-year incidence of cataract and cataract surgery. DESIGN: Population-based cohort study. PARTICIPANTS: Of the 3654 participants (aged 49 years or older) of the Blue Mountains Eye Study (BMES I) baseline examination (during 1992 to 1994), 2334 (75%) were reexamined after 5 years from 1997 to 1999 (BMES II). METHOD: Risk factor data were collected for all participants at baseline (BMES I). Assessment of renal function was based on estimated creatinine clearance (C(Cr)) calculated with the Cockcroft-Gault formula, adjusted for body surface area, and expressed in ml/minute/1.73 m2. Cataract incidence was determined from graded photographs. The association between renal function and incidence of cataract and cataract surgery was analyzed by logistic regression. MAIN OUTCOME MEASURES: Incidence of nuclear, cortical, and posterior subcapsular cataract, and cataract surgery. RESULTS: Mean C(Cr) +/- standard deviation was 60+/-13 ml/minute/1.73 m2. The overall 5-year incidence of nuclear, cortical, and posterior subcapsular cataract was 35.7% (417 of 1167 participants at risk), 16.7% (274 of 1641), and 4.3% (77 of 1790), respectively. Cataract surgery was performed in 6.8% (144 of 2123) of participants. There were no significant associations of renal function with incident nuclear (odds ratio [OR], 1.0; 95% confidence interval [CI], 0.99-1.02), cortical (OR, 1.0; CI, 0.98-1.01), and posterior subcapsular cataract (OR, 1.0; CI, 0.99-1.04) after adjusting for multiple risk factors. After adjusting for age, gender, and dark brown iris color, moderate or worse renal impairment (C(Cr) <60 ml/minute/1.73 m2) compared with normal or mildly impaired function (C(Cr) > or =60 ml/minute/1.73 m2) was significantly associated with incident cataract surgery (P<0.05), but the effect depended on age. Participants younger than 60 years of age with moderate to severe renal impairment had increased odds of incident cataract surgery (OR, 2.75; CI, 1.06-7.14), but this OR decreased with age. In participants 80 years old or older, the OR was 0.34 (CI, 0.11-1.10). CONCLUSIONS: There were no significant effects of renal function on the incidence of cataract of any type. The effect of moderate or worse renal impairment on incident cataract surgery depended on age. However, the interpretation of this effect is uncertain because of additional factors that may be involved in patients having surgery. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/15691566/Is_renal_impairment_a_predictor_of_the_incidence_of_cataract_or_cataract_surgery_Findings_from_a_population_based_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(04)01486-1 DB - PRIME DP - Unbound Medicine ER -