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Acute effects of caffeine on arterial stiffness, wave reflections, and central aortic pressures.

Abstract

Caffeine is considered to be the most widely consumed pharmacologic substance in the world. Several recent sources of evidence suggest that caffeine, besides its well-established pressor effects, provokes further alterations in arterial stiffness, wave reflections, and especially aortic blood pressures, which are often overlooked. The increasing evidence regarding the prognostic value of the latter cardiovascular factors prompted us to seek additional information concerning the relationship of aortic blood pressures to caffeine consumption. The main purpose of the present review was to evaluate the acute influence of caffeine on arterial stiffness, wave reflections, and central systolic pressures, which are involved in the pathogenesis and prognosis of cardiovascular diseases. Current evidence supports the hypothesis that caffeine influences the cardiovascular system at least acutely, not only through a peripheral blood pressure elevation but also through an increase in arterial stiffness and an enhancement of arterial wave reflections. Moreover, it seems that peripheral pressure measurements might have underestimated caffeine pressor effects, as a significantly greater response is observed in aortic pressures. The mechanisms explaining these effects of caffeine are not always clear, and neither is the role of caffeine in cardiovascular risk. However, it is concluded that strategies aiming at the control of dietary caffeine consumption merit serious consideration.

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  • Authors+Show Affiliations

    ,

    Vascular Laboratory, Department of Clinical Therapeutics, Alexandra University Hospital, National and Kapodistrian University of Athens, Greece. theopap@mail.ntua.gr

    , , ,

    Source

    American journal of hypertension 18:1 2005 Jan pg 129-36

    MeSH

    Aorta
    Arteries
    Blood Flow Velocity
    Blood Pressure
    Caffeine
    Cardiovascular Diseases
    Central Nervous System Stimulants
    Humans
    Phosphodiesterase Inhibitors
    Risk Factors
    Vascular Resistance

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    15691627

    Citation

    Papaioannou, Theodoros G., et al. "Acute Effects of Caffeine On Arterial Stiffness, Wave Reflections, and Central Aortic Pressures." American Journal of Hypertension, vol. 18, no. 1, 2005, pp. 129-36.
    Papaioannou TG, Karatzi K, Karatzis E, et al. Acute effects of caffeine on arterial stiffness, wave reflections, and central aortic pressures. Am J Hypertens. 2005;18(1):129-36.
    Papaioannou, T. G., Karatzi, K., Karatzis, E., Papamichael, C., & Lekakis, J. P. (2005). Acute effects of caffeine on arterial stiffness, wave reflections, and central aortic pressures. American Journal of Hypertension, 18(1), pp. 129-36.
    Papaioannou TG, et al. Acute Effects of Caffeine On Arterial Stiffness, Wave Reflections, and Central Aortic Pressures. Am J Hypertens. 2005;18(1):129-36. PubMed PMID: 15691627.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Acute effects of caffeine on arterial stiffness, wave reflections, and central aortic pressures. AU - Papaioannou,Theodoros G, AU - Karatzi,Kalliopi, AU - Karatzis,Emmanouil, AU - Papamichael,Christos, AU - Lekakis,John P, PY - 2004/05/29/received PY - 2004/08/11/revised PY - 2004/08/12/accepted PY - 2005/2/5/pubmed PY - 2006/6/6/medline PY - 2005/2/5/entrez SP - 129 EP - 36 JF - American journal of hypertension JO - Am. J. Hypertens. VL - 18 IS - 1 N2 - Caffeine is considered to be the most widely consumed pharmacologic substance in the world. Several recent sources of evidence suggest that caffeine, besides its well-established pressor effects, provokes further alterations in arterial stiffness, wave reflections, and especially aortic blood pressures, which are often overlooked. The increasing evidence regarding the prognostic value of the latter cardiovascular factors prompted us to seek additional information concerning the relationship of aortic blood pressures to caffeine consumption. The main purpose of the present review was to evaluate the acute influence of caffeine on arterial stiffness, wave reflections, and central systolic pressures, which are involved in the pathogenesis and prognosis of cardiovascular diseases. Current evidence supports the hypothesis that caffeine influences the cardiovascular system at least acutely, not only through a peripheral blood pressure elevation but also through an increase in arterial stiffness and an enhancement of arterial wave reflections. Moreover, it seems that peripheral pressure measurements might have underestimated caffeine pressor effects, as a significantly greater response is observed in aortic pressures. The mechanisms explaining these effects of caffeine are not always clear, and neither is the role of caffeine in cardiovascular risk. However, it is concluded that strategies aiming at the control of dietary caffeine consumption merit serious consideration. SN - 0895-7061 UR - https://www.unboundmedicine.com/medline/citation/15691627/Acute_effects_of_caffeine_on_arterial_stiffness_wave_reflections_and_central_aortic_pressures_ L2 - https://academic.oup.com/ajh/article-lookup/doi/10.1016/j.amjhyper.2004.08.017 DB - PRIME DP - Unbound Medicine ER -