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Effects of vitamins C and E on oxidative stress markers and endothelial function in patients with systemic lupus erythematosus: a double blind, placebo controlled pilot study.
J Rheumatol. 2005 Feb; 32(2):275-82.JR

Abstract

OBJECTIVE

Patients with systemic lupus erythematosus (SLE) experience excess morbidity and mortality due to coronary artery disease (CAD) that cannot be fully explained by the classical CAD risk factors. Among emerging CAD risk factors, oxidative stress is currently being emphasized. We evaluated the effects of longterm antioxidant vitamins on markers of oxidative stress and antioxidant defense and endothelial function in 39 patients with SLE.

METHODS

Patients were randomized to receive either placebo or vitamins (500 mg vitamin C and 800 IU vitamin E daily) for 12 weeks. Markers of oxidative stress included malondialdehyde (MDA) and allantoin. Antioxidants measured included erythrocyte superoxide dismutase and glutathione peroxidase, plasma total antioxidant power (as FRAP value), and ascorbic acid and vitamin E concentrations. Endothelial function was assessed by flow-mediated dilatation (FMD) of the brachial artery and plasma concentration of von Willebrand factor (vWF) and plasminogen activator inhibitor type 1 (PAI-1). Primary outcome of the study included the change in lipid peroxidation as revealed by MDA levels. Secondary outcomes included changes in allantoin and antioxidant levels and change in endothelial function.

RESULTS

After treatment, plasma ascorbic acid and alpha-tocopherol concentrations were significantly (p < 0.05) increased only in the vitamin-treated group, associated with a significant decrease (p < 0.05) in plasma MDA. Other oxidative stress markers and antioxidant levels remained unchanged in both groups. FMD and vWF and PAI-1 levels remained unchanged in both groups.

CONCLUSION

Combined administration of vitamins C and E was associated with decreased lipid peroxidation, but did not affect endothelial function in patients with SLE after 3 months of therapy.

Authors+Show Affiliations

Department of Medicine and Therapeutics, Department of Radiology, and the Clinical Immunology Unit, Hong Kong Cancer Institute, Hong Kong. tamls_813@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15693087

Citation

Tam, Lai S., et al. "Effects of Vitamins C and E On Oxidative Stress Markers and Endothelial Function in Patients With Systemic Lupus Erythematosus: a Double Blind, Placebo Controlled Pilot Study." The Journal of Rheumatology, vol. 32, no. 2, 2005, pp. 275-82.
Tam LS, Li EK, Leung VY, et al. Effects of vitamins C and E on oxidative stress markers and endothelial function in patients with systemic lupus erythematosus: a double blind, placebo controlled pilot study. J Rheumatol. 2005;32(2):275-82.
Tam, L. S., Li, E. K., Leung, V. Y., Griffith, J. F., Benzie, I. F., Lim, P. L., Whitney, B., Lee, V. W., Lee, K. K., Thomas, G. N., & Tomlinson, B. (2005). Effects of vitamins C and E on oxidative stress markers and endothelial function in patients with systemic lupus erythematosus: a double blind, placebo controlled pilot study. The Journal of Rheumatology, 32(2), 275-82.
Tam LS, et al. Effects of Vitamins C and E On Oxidative Stress Markers and Endothelial Function in Patients With Systemic Lupus Erythematosus: a Double Blind, Placebo Controlled Pilot Study. J Rheumatol. 2005;32(2):275-82. PubMed PMID: 15693087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of vitamins C and E on oxidative stress markers and endothelial function in patients with systemic lupus erythematosus: a double blind, placebo controlled pilot study. AU - Tam,Lai S, AU - Li,Edmund K, AU - Leung,Vivian Y F, AU - Griffith,James F, AU - Benzie,Iris F F, AU - Lim,Pak L, AU - Whitney,Bruce, AU - Lee,Vivian W Y, AU - Lee,Kenneth K C, AU - Thomas,G Neil, AU - Tomlinson,Brian, PY - 2005/2/5/pubmed PY - 2005/4/29/medline PY - 2005/2/5/entrez SP - 275 EP - 82 JF - The Journal of rheumatology JO - J Rheumatol VL - 32 IS - 2 N2 - OBJECTIVE: Patients with systemic lupus erythematosus (SLE) experience excess morbidity and mortality due to coronary artery disease (CAD) that cannot be fully explained by the classical CAD risk factors. Among emerging CAD risk factors, oxidative stress is currently being emphasized. We evaluated the effects of longterm antioxidant vitamins on markers of oxidative stress and antioxidant defense and endothelial function in 39 patients with SLE. METHODS: Patients were randomized to receive either placebo or vitamins (500 mg vitamin C and 800 IU vitamin E daily) for 12 weeks. Markers of oxidative stress included malondialdehyde (MDA) and allantoin. Antioxidants measured included erythrocyte superoxide dismutase and glutathione peroxidase, plasma total antioxidant power (as FRAP value), and ascorbic acid and vitamin E concentrations. Endothelial function was assessed by flow-mediated dilatation (FMD) of the brachial artery and plasma concentration of von Willebrand factor (vWF) and plasminogen activator inhibitor type 1 (PAI-1). Primary outcome of the study included the change in lipid peroxidation as revealed by MDA levels. Secondary outcomes included changes in allantoin and antioxidant levels and change in endothelial function. RESULTS: After treatment, plasma ascorbic acid and alpha-tocopherol concentrations were significantly (p < 0.05) increased only in the vitamin-treated group, associated with a significant decrease (p < 0.05) in plasma MDA. Other oxidative stress markers and antioxidant levels remained unchanged in both groups. FMD and vWF and PAI-1 levels remained unchanged in both groups. CONCLUSION: Combined administration of vitamins C and E was associated with decreased lipid peroxidation, but did not affect endothelial function in patients with SLE after 3 months of therapy. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/15693087/Effects_of_vitamins_C_and_E_on_oxidative_stress_markers_and_endothelial_function_in_patients_with_systemic_lupus_erythematosus:_a_double_blind_placebo_controlled_pilot_study_ L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&amp;pmid=15693087 DB - PRIME DP - Unbound Medicine ER -