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Probiotic effects on faecal inflammatory markers and on faecal IgA in food allergic atopic eczema/dermatitis syndrome infants.

Abstract

Probiotic bacteria are proposed to alleviate intestinal inflammation in infants with atopic eczema/dermatitis syndrome (AEDS) and food allergy. In such infants we investigated effects of probiotic bacteria on faecal IgA, and on the intestinal inflammation markers tumour necrosis factor-alpha (TNF-alpha), alpha1-antitrypsin (AT), and eosinophil cationic protein (ECP). A total of 230 infants with AEDS and suspected cow's milk allergy (CMA) received in a randomized double-blinded manner, concomitant with elimination diet, Lactobacillus GG (LGG), a mixture of four probiotic strains (MIX), or placebo for 4 wk. Four weeks after treatment, CMA was diagnosed with a double-blind placebo-controlled milk challenge. Faecal samples of 102 infants, randomly chosen for analysis, were collected before treatment, after 4-wk treatment, and on the first day of milk challenge. After treatment, IgA levels tended to be higher in probiotic groups than in the placebo group (LGG vs. placebo, p=0.064; MIX vs. placebo, p=0.064), and AT decreased in the LGG group, but not in other treatment groups. After challenge in IgE-associated CMA infants, faecal IgA was higher for LGG than for placebo (p=0.014), and TNF-alpha was lower for LGG than for placebo, but non-significantly (p=0.111). In conclusion, 4-wk treatment with LGG may alleviate intestinal inflammation in infants with AEDS and CMA.

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  • Authors+Show Affiliations

    ,

    The Skin and Allergy Hospital, University of Helsinki, Helsinki, Finland. mirva.viljanen@hus.fi

    , , , ,

    Source

    MeSH

    Biomarkers
    Dermatitis, Atopic
    Double-Blind Method
    Eosinophil Cationic Protein
    Feces
    Female
    Food Hypersensitivity
    Humans
    Immunoglobulin A
    Infant
    Inflammation
    Intestines
    Lactobacillus
    Male
    Milk Hypersensitivity
    Probiotics
    Syndrome
    Treatment Outcome
    Tumor Necrosis Factor-alpha
    alpha 1-Antitrypsin

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15693914

    Citation

    Viljanen, Mirva, et al. "Probiotic Effects On Faecal Inflammatory Markers and On Faecal IgA in Food Allergic Atopic Eczema/dermatitis Syndrome Infants." Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, vol. 16, no. 1, 2005, pp. 65-71.
    Viljanen M, Kuitunen M, Haahtela T, et al. Probiotic effects on faecal inflammatory markers and on faecal IgA in food allergic atopic eczema/dermatitis syndrome infants. Pediatr Allergy Immunol. 2005;16(1):65-71.
    Viljanen, M., Kuitunen, M., Haahtela, T., Juntunen-Backman, K., Korpela, R., & Savilahti, E. (2005). Probiotic effects on faecal inflammatory markers and on faecal IgA in food allergic atopic eczema/dermatitis syndrome infants. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, 16(1), pp. 65-71.
    Viljanen M, et al. Probiotic Effects On Faecal Inflammatory Markers and On Faecal IgA in Food Allergic Atopic Eczema/dermatitis Syndrome Infants. Pediatr Allergy Immunol. 2005;16(1):65-71. PubMed PMID: 15693914.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Probiotic effects on faecal inflammatory markers and on faecal IgA in food allergic atopic eczema/dermatitis syndrome infants. AU - Viljanen,Mirva, AU - Kuitunen,Mikael, AU - Haahtela,Tari, AU - Juntunen-Backman,Kaisu, AU - Korpela,Riitta, AU - Savilahti,Erkki, PY - 2005/2/8/pubmed PY - 2005/9/1/medline PY - 2005/2/8/entrez SP - 65 EP - 71 JF - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JO - Pediatr Allergy Immunol VL - 16 IS - 1 N2 - Probiotic bacteria are proposed to alleviate intestinal inflammation in infants with atopic eczema/dermatitis syndrome (AEDS) and food allergy. In such infants we investigated effects of probiotic bacteria on faecal IgA, and on the intestinal inflammation markers tumour necrosis factor-alpha (TNF-alpha), alpha1-antitrypsin (AT), and eosinophil cationic protein (ECP). A total of 230 infants with AEDS and suspected cow's milk allergy (CMA) received in a randomized double-blinded manner, concomitant with elimination diet, Lactobacillus GG (LGG), a mixture of four probiotic strains (MIX), or placebo for 4 wk. Four weeks after treatment, CMA was diagnosed with a double-blind placebo-controlled milk challenge. Faecal samples of 102 infants, randomly chosen for analysis, were collected before treatment, after 4-wk treatment, and on the first day of milk challenge. After treatment, IgA levels tended to be higher in probiotic groups than in the placebo group (LGG vs. placebo, p=0.064; MIX vs. placebo, p=0.064), and AT decreased in the LGG group, but not in other treatment groups. After challenge in IgE-associated CMA infants, faecal IgA was higher for LGG than for placebo (p=0.014), and TNF-alpha was lower for LGG than for placebo, but non-significantly (p=0.111). In conclusion, 4-wk treatment with LGG may alleviate intestinal inflammation in infants with AEDS and CMA. SN - 0905-6157 UR - https://www.unboundmedicine.com/medline/citation/15693914/full_citation L2 - https://doi.org/10.1111/j.1399-3038.2005.00224.x DB - PRIME DP - Unbound Medicine ER -