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Dantrolene and heatstroke: a good molecule applied in an unsuitable situation.
Crit Care. 2005 Feb; 9(1):23-4.CC

Abstract

Because they share one pathognomonic sign (major hyperthermia), classic or environmental heatstroke and malignant hyperthermia have often been confronted from the therapeutic point of view. As expected and according to major physiopathological discrepancies between both syndromes, analysis of published data does not support effectiveness of dantrolene in heatstroke despite its significant reduction in mortality in malignant hyperthermia. If cooling methods still represent the cornerstone of the heatstroke therapeutic approach, the magnitude of heat-related deaths and the morbidity associated with the August 2003 French heatwave have highlighted the need for more ambitious methods of treatment.

Authors+Show Affiliations

Service d'accueil des urgences, Centre Hospitalier Universitaire Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie, Paris, France. pierre.hausfater@psl.ap-hop-paris.fr

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15693976

Citation

Hausfater, Pierre. "Dantrolene and Heatstroke: a Good Molecule Applied in an Unsuitable Situation." Critical Care (London, England), vol. 9, no. 1, 2005, pp. 23-4.
Hausfater P. Dantrolene and heatstroke: a good molecule applied in an unsuitable situation. Crit Care. 2005;9(1):23-4.
Hausfater, P. (2005). Dantrolene and heatstroke: a good molecule applied in an unsuitable situation. Critical Care (London, England), 9(1), 23-4.
Hausfater P. Dantrolene and Heatstroke: a Good Molecule Applied in an Unsuitable Situation. Crit Care. 2005;9(1):23-4. PubMed PMID: 15693976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dantrolene and heatstroke: a good molecule applied in an unsuitable situation. A1 - Hausfater,Pierre, Y1 - 2004/09/03/ PY - 2005/2/8/pubmed PY - 2006/3/10/medline PY - 2005/2/8/entrez SP - 23 EP - 4 JF - Critical care (London, England) JO - Crit Care VL - 9 IS - 1 N2 - Because they share one pathognomonic sign (major hyperthermia), classic or environmental heatstroke and malignant hyperthermia have often been confronted from the therapeutic point of view. As expected and according to major physiopathological discrepancies between both syndromes, analysis of published data does not support effectiveness of dantrolene in heatstroke despite its significant reduction in mortality in malignant hyperthermia. If cooling methods still represent the cornerstone of the heatstroke therapeutic approach, the magnitude of heat-related deaths and the morbidity associated with the August 2003 French heatwave have highlighted the need for more ambitious methods of treatment. SN - 1466-609X UR - https://www.unboundmedicine.com/medline/citation/15693976/Dantrolene_and_heatstroke:_a_good_molecule_applied_in_an_unsuitable_situation_ L2 - https://ccforum.biomedcentral.com/articles/10.1186/cc2939 DB - PRIME DP - Unbound Medicine ER -