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Subtotal and total resection of superficial plexiform neurofibromas of face and neck: four case reports.
J Craniomaxillofac Surg. 2005 Feb; 33(1):55-60.JC

Abstract

INTRODUCTION

Plexiform neurofibromas are benign tumours of the peripheral nerves and connective tissue. They develop most often in patients with neurofibromatosis type 1 (NF1) and often grow continuously. Removal of plexiform neurofibromas is usually unsatisfactory because the network-like growth of these tumours often involves multiple nerve fascicles and other adjacent tissues. It has been previously shown that magnetic resonance tomography can distinguish the growth patterns of plexiform neurofibromas into three different categories: superficial, displacing and invasive.

PATIENTS AND METHODS

Three cases are described with successful subtotal resections of superficial plexiform neurofibromas, and one case with total resection following the diagnosis of tumour subtype using magnetic resonance imaging (MRI).

RESULTS

There was a significant, lasting improvement in appearance which demonstrates that surgical intervention in the case of superficial plexiform neurofibroma is valuable.

CONCLUSION

Careful classification of plexiform neurofibroma by means of MRI provides valuable information for the surgical management of patients. It enables the distinction to be drawn between this subtype and the other two subtypes of plexiform neurofibromas.

Authors+Show Affiliations

Department of Maxillofacial Surgery, University Hospital Hamburg-Eppendorf, Germany. rfriedri@uke.uni-hamburg.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15694151

Citation

Friedrich, Reinhard E., et al. "Subtotal and Total Resection of Superficial Plexiform Neurofibromas of Face and Neck: Four Case Reports." Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery, vol. 33, no. 1, 2005, pp. 55-60.
Friedrich RE, Schmelzle R, Hartmann M, et al. Subtotal and total resection of superficial plexiform neurofibromas of face and neck: four case reports. J Craniomaxillofac Surg. 2005;33(1):55-60.
Friedrich, R. E., Schmelzle, R., Hartmann, M., & Mautner, V. F. (2005). Subtotal and total resection of superficial plexiform neurofibromas of face and neck: four case reports. Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery, 33(1), 55-60.
Friedrich RE, et al. Subtotal and Total Resection of Superficial Plexiform Neurofibromas of Face and Neck: Four Case Reports. J Craniomaxillofac Surg. 2005;33(1):55-60. PubMed PMID: 15694151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subtotal and total resection of superficial plexiform neurofibromas of face and neck: four case reports. AU - Friedrich,Reinhard E, AU - Schmelzle,Rainer, AU - Hartmann,Melanie, AU - Mautner,Victor-F, Y1 - 2005/01/12/ PY - 2003/12/02/received PY - 2004/08/12/accepted PY - 2005/2/8/pubmed PY - 2005/4/29/medline PY - 2005/2/8/entrez SP - 55 EP - 60 JF - Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery JO - J Craniomaxillofac Surg VL - 33 IS - 1 N2 - INTRODUCTION: Plexiform neurofibromas are benign tumours of the peripheral nerves and connective tissue. They develop most often in patients with neurofibromatosis type 1 (NF1) and often grow continuously. Removal of plexiform neurofibromas is usually unsatisfactory because the network-like growth of these tumours often involves multiple nerve fascicles and other adjacent tissues. It has been previously shown that magnetic resonance tomography can distinguish the growth patterns of plexiform neurofibromas into three different categories: superficial, displacing and invasive. PATIENTS AND METHODS: Three cases are described with successful subtotal resections of superficial plexiform neurofibromas, and one case with total resection following the diagnosis of tumour subtype using magnetic resonance imaging (MRI). RESULTS: There was a significant, lasting improvement in appearance which demonstrates that surgical intervention in the case of superficial plexiform neurofibroma is valuable. CONCLUSION: Careful classification of plexiform neurofibroma by means of MRI provides valuable information for the surgical management of patients. It enables the distinction to be drawn between this subtype and the other two subtypes of plexiform neurofibromas. SN - 1010-5182 UR - https://www.unboundmedicine.com/medline/citation/15694151/Subtotal_and_total_resection_of_superficial_plexiform_neurofibromas_of_face_and_neck:_four_case_reports_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1010-5182(04)00122-2 DB - PRIME DP - Unbound Medicine ER -