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Endometrium from women with and without endometriosis, and peritoneal, ovarian and bowel endometriosis, show different c-kit protein expression.
J Reprod Immunol. 2005 Feb; 65(1):55-63.JR

Abstract

BACKGROUND

Endometriosis is defined by the presence of endometrium outside the uterus. Changes in the expression of the proto-oncogene c-kit are associated with aggressive behaviour of both benign and malignant tumours, but there are few data on its c-kit expression in endometriosis. Here we examined c-kit expression in endometrium and endometriotic tissue.

METHODS

Immunohistochemistry was used for qualitative and semi-quantitative (mean+/-S.D. positive cells) analysis of c-kit expression in endometrium from women with (n=9) and without endometriosis (n=18), and in peritoneal (n=20), ovarian (n=20) and colorectal endometriosis (n=20).

RESULTS

Semi-quantitative c-kit expression was higher in endometrial glandular cells from women with endometriosis than from women without endometriosis (15.0+/-14.6% versus 3.9+/-7.4%, p=0.01). No difference in c-kit expression was found in qualitative analysis and according to the phase of the menstrual cycle. C-kit expression values in peritoneal, ovarian and colorectal endometriosis were 2.0+/-3.8%, 2.0+/-4.1% and 21.7+/-18.4%, respectively. Qualitative and semi-quantitative c-kit expression was higher in colorectal endometriosis than in peritoneal and ovarian endometriosis (p<0.001); no difference was found between ovarian and peritoneal endometriosis. No c-kit expression was detected in stromal cells of either endometrium or endometriotic tissue.

CONCLUSION

These results suggest that the c-kit/stem cell factor axis is involved in the pathogenesis of endometriosis. Strong c-kit protein expression was associated with invasive endometriotic lesions.

Authors+Show Affiliations

Service d'Anatomie Pathologie, Hôpital Tenon, AP-HP, 4 rue de la Chine, 75020 Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15694967

Citation

Uzan, Catherine, et al. "Endometrium From Women With and Without Endometriosis, and Peritoneal, Ovarian and Bowel Endometriosis, Show Different C-kit Protein Expression." Journal of Reproductive Immunology, vol. 65, no. 1, 2005, pp. 55-63.
Uzan C, Cortez A, Dufournet C, et al. Endometrium from women with and without endometriosis, and peritoneal, ovarian and bowel endometriosis, show different c-kit protein expression. J Reprod Immunol. 2005;65(1):55-63.
Uzan, C., Cortez, A., Dufournet, C., Fauvet, R., Siffroi, J. P., & Daraï, E. (2005). Endometrium from women with and without endometriosis, and peritoneal, ovarian and bowel endometriosis, show different c-kit protein expression. Journal of Reproductive Immunology, 65(1), 55-63.
Uzan C, et al. Endometrium From Women With and Without Endometriosis, and Peritoneal, Ovarian and Bowel Endometriosis, Show Different C-kit Protein Expression. J Reprod Immunol. 2005;65(1):55-63. PubMed PMID: 15694967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endometrium from women with and without endometriosis, and peritoneal, ovarian and bowel endometriosis, show different c-kit protein expression. AU - Uzan,Catherine, AU - Cortez,Annie, AU - Dufournet,Charlotte, AU - Fauvet,Raffaèle, AU - Siffroi,Jean-Pierre, AU - Daraï,Emile, PY - 2004/07/28/received PY - 2004/09/10/revised PY - 2004/09/14/accepted PY - 2005/2/8/pubmed PY - 2005/6/17/medline PY - 2005/2/8/entrez SP - 55 EP - 63 JF - Journal of reproductive immunology JO - J. Reprod. Immunol. VL - 65 IS - 1 N2 - BACKGROUND: Endometriosis is defined by the presence of endometrium outside the uterus. Changes in the expression of the proto-oncogene c-kit are associated with aggressive behaviour of both benign and malignant tumours, but there are few data on its c-kit expression in endometriosis. Here we examined c-kit expression in endometrium and endometriotic tissue. METHODS: Immunohistochemistry was used for qualitative and semi-quantitative (mean+/-S.D. positive cells) analysis of c-kit expression in endometrium from women with (n=9) and without endometriosis (n=18), and in peritoneal (n=20), ovarian (n=20) and colorectal endometriosis (n=20). RESULTS: Semi-quantitative c-kit expression was higher in endometrial glandular cells from women with endometriosis than from women without endometriosis (15.0+/-14.6% versus 3.9+/-7.4%, p=0.01). No difference in c-kit expression was found in qualitative analysis and according to the phase of the menstrual cycle. C-kit expression values in peritoneal, ovarian and colorectal endometriosis were 2.0+/-3.8%, 2.0+/-4.1% and 21.7+/-18.4%, respectively. Qualitative and semi-quantitative c-kit expression was higher in colorectal endometriosis than in peritoneal and ovarian endometriosis (p<0.001); no difference was found between ovarian and peritoneal endometriosis. No c-kit expression was detected in stromal cells of either endometrium or endometriotic tissue. CONCLUSION: These results suggest that the c-kit/stem cell factor axis is involved in the pathogenesis of endometriosis. Strong c-kit protein expression was associated with invasive endometriotic lesions. SN - 0165-0378 UR - https://www.unboundmedicine.com/medline/citation/15694967/Endometrium_from_women_with_and_without_endometriosis_and_peritoneal_ovarian_and_bowel_endometriosis_show_different_c_kit_protein_expression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0378(04)00146-9 DB - PRIME DP - Unbound Medicine ER -