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Usefulness of plasma B-type natriuretic peptide to identify ventricular dysfunction in pediatric and adult patients with congenital heart disease.
Am J Cardiol. 2005 Feb 15; 95(4):474-8.AJ

Abstract

The usefulness of B-type natriuretic peptide (BNP) levels to assess ventricular dysfunction in children and the congenital heart disease population remains largely unknown. We retrospectively analyzed 62 patients with or without known heart disease who had plasma BNP measured for the investigation of new or severity grading of known ventricular dysfunction. BNP levels were significantly higher in patients with ventricular dysfunction (mean 623 +/- 146 pg/ml, range 5 to 5,000) than in patients without ventricular dysfunction (mean 22 +/- 5 pg/ml, range 5 to 63; p <0.01). Using a cutoff of 40 pg/ml, BNP levels detected heart disease associated with ventricular dysfunction at a sensitivity of 85%, specificity of 81%, positive predictive value of 92%, and negative predictive value of 68%. The degree of BNP elevation was also associated with the severity of heart failure and high ventricular filling pressures. Plasma BNP elevation can be a reliable test in children and young adults with various kinds of congenital heart disease resulting in ventricular dysfunction.

Authors+Show Affiliations

Division of Pediatric Cardiology, Doernbecher Children's Hospital, Oregon Health & Science University, Portland, Oregon, USA. lawy@ohsu.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15695131

Citation

Law, Yuk M., et al. "Usefulness of Plasma B-type Natriuretic Peptide to Identify Ventricular Dysfunction in Pediatric and Adult Patients With Congenital Heart Disease." The American Journal of Cardiology, vol. 95, no. 4, 2005, pp. 474-8.
Law YM, Keller BB, Feingold BM, et al. Usefulness of plasma B-type natriuretic peptide to identify ventricular dysfunction in pediatric and adult patients with congenital heart disease. Am J Cardiol. 2005;95(4):474-8.
Law, Y. M., Keller, B. B., Feingold, B. M., & Boyle, G. J. (2005). Usefulness of plasma B-type natriuretic peptide to identify ventricular dysfunction in pediatric and adult patients with congenital heart disease. The American Journal of Cardiology, 95(4), 474-8.
Law YM, et al. Usefulness of Plasma B-type Natriuretic Peptide to Identify Ventricular Dysfunction in Pediatric and Adult Patients With Congenital Heart Disease. Am J Cardiol. 2005 Feb 15;95(4):474-8. PubMed PMID: 15695131.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Usefulness of plasma B-type natriuretic peptide to identify ventricular dysfunction in pediatric and adult patients with congenital heart disease. AU - Law,Yuk M, AU - Keller,Bradley B, AU - Feingold,Brian M, AU - Boyle,Gerard J, PY - 2004/07/27/received PY - 2004/10/01/revised PY - 2004/10/01/accepted PY - 2005/2/8/pubmed PY - 2005/4/6/medline PY - 2005/2/8/entrez SP - 474 EP - 8 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 95 IS - 4 N2 - The usefulness of B-type natriuretic peptide (BNP) levels to assess ventricular dysfunction in children and the congenital heart disease population remains largely unknown. We retrospectively analyzed 62 patients with or without known heart disease who had plasma BNP measured for the investigation of new or severity grading of known ventricular dysfunction. BNP levels were significantly higher in patients with ventricular dysfunction (mean 623 +/- 146 pg/ml, range 5 to 5,000) than in patients without ventricular dysfunction (mean 22 +/- 5 pg/ml, range 5 to 63; p <0.01). Using a cutoff of 40 pg/ml, BNP levels detected heart disease associated with ventricular dysfunction at a sensitivity of 85%, specificity of 81%, positive predictive value of 92%, and negative predictive value of 68%. The degree of BNP elevation was also associated with the severity of heart failure and high ventricular filling pressures. Plasma BNP elevation can be a reliable test in children and young adults with various kinds of congenital heart disease resulting in ventricular dysfunction. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/15695131/Usefulness_of_plasma_B_type_natriuretic_peptide_to_identify_ventricular_dysfunction_in_pediatric_and_adult_patients_with_congenital_heart_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(04)01686-8 DB - PRIME DP - Unbound Medicine ER -