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Cognitive and psychomotor performance, mood, and pressor effects of caffeine after 4, 6 and 8 h caffeine abstinence.
Psychopharmacology (Berl) 2005; 178(4):461-70P

Abstract

RATIONALE

Many studies have found that caffeine consumed after overnight caffeine abstinence improves cognitive performance and mood. Much less is known, however, about the effects of caffeine after shorter periods of caffeine abstinence.

OBJECTIVES

The aim of this study was to measure the effects on psychomotor and cognitive performance, mood, hand steadiness, blood pressure and heart rate of caffeine administration after periods of 4, 6, and 8 h of caffeine abstinence.

METHODS

Participants (n = 49, 27 female) were moderate to moderate-high caffeine consumers (mean daily intake 370 mg/day). Following overnight caffeine abstinence, a 'pre-dose' of caffeine (1.2 mg/kg) was administered at 9 A.M, 11 A.M or 1 P.M. The participants started a baseline battery of measurements at 4 P.M.: before receiving caffeine (1.2 mg/kg) or placebo at 5 P.M.: They then performed the battery of tests again, starting at 5:30 P.M. This was a double-blind, placebo-controlled, randomised study.

RESULTS

Performance and mood measurements confirmed a psychostimulant action of caffeine (versus placebo), but only after 8 h of caffeine abstinence. Caffeine also increased blood pressure after 8-h abstinence, whereas hand steadiness was decreased and perception of task demand was increased by caffeine after 4 h, but not after 6- and 8-h abstinence.

CONCLUSIONS

A second cup-of-coffee equivalent dose of caffeine only reliably affected cognitive performance and mood after an 8-h interval between doses, but not after shorter intervals (when caffeine had some adverse effects). These results show that, apart from caffeine consumption soon after waking, the daily pattern of caffeine intake of many typical caffeine consumers is not well explained by the short-term psychostimulant effects of caffeine.

Authors+Show Affiliations

Department of Experimental Psychology, University of Bristol, 8 Woodland Road, Bristol, BS8 1TN, UK, peter.rogers@bristol.ac.uk.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15696321

Citation

Heatherley, Susan V., et al. "Cognitive and Psychomotor Performance, Mood, and Pressor Effects of Caffeine After 4, 6 and 8 H Caffeine Abstinence." Psychopharmacology, vol. 178, no. 4, 2005, pp. 461-70.
Heatherley SV, Hayward RC, Seers HE, et al. Cognitive and psychomotor performance, mood, and pressor effects of caffeine after 4, 6 and 8 h caffeine abstinence. Psychopharmacology (Berl). 2005;178(4):461-70.
Heatherley, S. V., Hayward, R. C., Seers, H. E., & Rogers, P. J. (2005). Cognitive and psychomotor performance, mood, and pressor effects of caffeine after 4, 6 and 8 h caffeine abstinence. Psychopharmacology, 178(4), pp. 461-70.
Heatherley SV, et al. Cognitive and Psychomotor Performance, Mood, and Pressor Effects of Caffeine After 4, 6 and 8 H Caffeine Abstinence. Psychopharmacology (Berl). 2005;178(4):461-70. PubMed PMID: 15696321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cognitive and psychomotor performance, mood, and pressor effects of caffeine after 4, 6 and 8 h caffeine abstinence. AU - Heatherley,Susan V, AU - Hayward,Robert C, AU - Seers,Helen E, AU - Rogers,Peter J, Y1 - 2005/02/05/ PY - 2004/04/19/received PY - 2004/07/30/accepted PY - 2005/2/8/pubmed PY - 2005/10/21/medline PY - 2005/2/8/entrez SP - 461 EP - 70 JF - Psychopharmacology JO - Psychopharmacology (Berl.) VL - 178 IS - 4 N2 - RATIONALE: Many studies have found that caffeine consumed after overnight caffeine abstinence improves cognitive performance and mood. Much less is known, however, about the effects of caffeine after shorter periods of caffeine abstinence. OBJECTIVES: The aim of this study was to measure the effects on psychomotor and cognitive performance, mood, hand steadiness, blood pressure and heart rate of caffeine administration after periods of 4, 6, and 8 h of caffeine abstinence. METHODS: Participants (n = 49, 27 female) were moderate to moderate-high caffeine consumers (mean daily intake 370 mg/day). Following overnight caffeine abstinence, a 'pre-dose' of caffeine (1.2 mg/kg) was administered at 9 A.M, 11 A.M or 1 P.M. The participants started a baseline battery of measurements at 4 P.M.: before receiving caffeine (1.2 mg/kg) or placebo at 5 P.M.: They then performed the battery of tests again, starting at 5:30 P.M. This was a double-blind, placebo-controlled, randomised study. RESULTS: Performance and mood measurements confirmed a psychostimulant action of caffeine (versus placebo), but only after 8 h of caffeine abstinence. Caffeine also increased blood pressure after 8-h abstinence, whereas hand steadiness was decreased and perception of task demand was increased by caffeine after 4 h, but not after 6- and 8-h abstinence. CONCLUSIONS: A second cup-of-coffee equivalent dose of caffeine only reliably affected cognitive performance and mood after an 8-h interval between doses, but not after shorter intervals (when caffeine had some adverse effects). These results show that, apart from caffeine consumption soon after waking, the daily pattern of caffeine intake of many typical caffeine consumers is not well explained by the short-term psychostimulant effects of caffeine. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/15696321/Cognitive_and_psychomotor_performance_mood_and_pressor_effects_of_caffeine_after_4_6_and_8_h_caffeine_abstinence_ L2 - https://dx.doi.org/10.1007/s00213-005-2159-9 DB - PRIME DP - Unbound Medicine ER -