Tags

Type your tag names separated by a space and hit enter

Uric acid: an abettor or protector in calcium oxalate urolithiasis? Biochemical study in stone formers.
Clin Chim Acta 2005; 353(1-2):45-51CC

Abstract

BACKGROUND

Free radical induced renal damage leads to crystal retention and formation of large stones. However, the scenario behind uric acid (UA) stone formation is still a mystery, as uric acid, a risk factor of stone formation, seems to be a potent antioxidant that can protect cells from damage by reactive oxygen species. This study was intended to evaluate the role of uric acid in stone formers by assessing the oxidative stress status of the stone patients.

METHODS

Determination of urinary stone forming risk factors and oxidative stress factors like plasma lipid peroxidation, protein carbonyls of stone formers and histopathological changes and uric acid deposition in stone patients kidney biopsy were studied.

RESULTS

Increased concentrations of urinary uric acid and oxalate in both uric acid as well as calcium oxalate stone formers were observed, whereas calcium is increased in calcium stone formers and not in the uric acid stone patients. Inhibitors such as citrate and glycosaminoglycans (GAGs) were found to be significantly decreased in all the stone patients. Histopathological studies confirmed the deposition of crystals in the damaged tubules and De Galantha staining authenticates that the damage is caused due to uric acid crystals. Increased oxidative stress is dictated by the concentrations of lipid peroxidation and protein carbonyls in stone formers. Moreover, increased activities of urinary marker enzymes substantiate the tubular damage.

CONCLUSION

We speculated that uric acid acts as a calculi forming salt rather than an antioxidant and it has no role in preventing oxidative stress pertaining to urolithiasis.

Authors+Show Affiliations

Department of Medical Biochemistry, Dr. A.L. Mudaliar Post Graduate Institute of Basic Medical Sciences, Taramani, University of Madras, Chennai 600 113, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15698589

Citation

Srinivasan, S, et al. "Uric Acid: an Abettor or Protector in Calcium Oxalate Urolithiasis? Biochemical Study in Stone Formers." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 353, no. 1-2, 2005, pp. 45-51.
Srinivasan S, Kalaiselvi P, Sakthivel R, et al. Uric acid: an abettor or protector in calcium oxalate urolithiasis? Biochemical study in stone formers. Clin Chim Acta. 2005;353(1-2):45-51.
Srinivasan, S., Kalaiselvi, P., Sakthivel, R., Pragasam, V., Muthu, V., & Varalakshmi, P. (2005). Uric acid: an abettor or protector in calcium oxalate urolithiasis? Biochemical study in stone formers. Clinica Chimica Acta; International Journal of Clinical Chemistry, 353(1-2), pp. 45-51.
Srinivasan S, et al. Uric Acid: an Abettor or Protector in Calcium Oxalate Urolithiasis? Biochemical Study in Stone Formers. Clin Chim Acta. 2005;353(1-2):45-51. PubMed PMID: 15698589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Uric acid: an abettor or protector in calcium oxalate urolithiasis? Biochemical study in stone formers. AU - Srinivasan,S, AU - Kalaiselvi,P, AU - Sakthivel,R, AU - Pragasam,V, AU - Muthu,V, AU - Varalakshmi,P, PY - 2004/08/06/received PY - 2004/09/30/revised PY - 2004/09/30/accepted PY - 2005/2/9/pubmed PY - 2005/4/23/medline PY - 2005/2/9/entrez SP - 45 EP - 51 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin. Chim. Acta VL - 353 IS - 1-2 N2 - BACKGROUND: Free radical induced renal damage leads to crystal retention and formation of large stones. However, the scenario behind uric acid (UA) stone formation is still a mystery, as uric acid, a risk factor of stone formation, seems to be a potent antioxidant that can protect cells from damage by reactive oxygen species. This study was intended to evaluate the role of uric acid in stone formers by assessing the oxidative stress status of the stone patients. METHODS: Determination of urinary stone forming risk factors and oxidative stress factors like plasma lipid peroxidation, protein carbonyls of stone formers and histopathological changes and uric acid deposition in stone patients kidney biopsy were studied. RESULTS: Increased concentrations of urinary uric acid and oxalate in both uric acid as well as calcium oxalate stone formers were observed, whereas calcium is increased in calcium stone formers and not in the uric acid stone patients. Inhibitors such as citrate and glycosaminoglycans (GAGs) were found to be significantly decreased in all the stone patients. Histopathological studies confirmed the deposition of crystals in the damaged tubules and De Galantha staining authenticates that the damage is caused due to uric acid crystals. Increased oxidative stress is dictated by the concentrations of lipid peroxidation and protein carbonyls in stone formers. Moreover, increased activities of urinary marker enzymes substantiate the tubular damage. CONCLUSION: We speculated that uric acid acts as a calculi forming salt rather than an antioxidant and it has no role in preventing oxidative stress pertaining to urolithiasis. SN - 0009-8981 UR - https://www.unboundmedicine.com/medline/citation/15698589/Uric_acid:_an_abettor_or_protector_in_calcium_oxalate_urolithiasis_Biochemical_study_in_stone_formers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(04)00484-X DB - PRIME DP - Unbound Medicine ER -