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Do statins reduce risk of incident dementia and Alzheimer disease? The Cache County Study.

Abstract

BACKGROUND

Prior reports suggest reduced occurrence of dementia and Alzheimer disease (AD) in statin users, but, to our knowledge, no prospective studies relate statin use and dementia incidence.

OBJECTIVE

To examine the association of statin use with both prevalence and incidence of dementia and AD.

DESIGN

Cross-sectional studies of prevalence and incidence and a prospective study of incidence of dementia and AD among 5092 elderly residents (aged 65 years or older) of a single county. Participants were assessed at home in 1995-1997 and again in 1998-2000. A detailed visual inventory of medicines, including statins and other lipid-lowering agents, was collected at both assessments.

MAIN OUTCOME MEASURES

Diagnosis of dementia and of AD.

RESULTS

From 4895 participants with data sufficient to determine cognitive status, we identified 355 cases of prevalent dementia (200 with AD) at initial assessment. Statin use was inversely associated with prevalence of dementia (adjusted odds ratio, 0.44; 95% confidence interval, 0.17-0.94). Three years later, we identified 185 cases of incident dementia (104 with AD) among 3308 survivors at risk. Statin use at baseline did not predict incidence of dementia or AD (adjusted hazard ratio for dementia, 1.19; 95% confidence interval, 0.53-2.34; adjusted hazard ratio for AD, 1.19; 95% confidence interval, 0.35-2.96), nor did statin use at follow-up (adjusted odds ratio for dementia, 1.04; 95% confidence interval, 0.56-1.81; adjusted odds ratio for AD, 0.85; 95% confidence interval, 0.32-1.88).

CONCLUSIONS

Although statin use might be less frequent in those with prevalent dementia, we found no association between statin use and subsequent onset of dementia or AD. Further research is warranted before costly dementia prevention trials with statins are undertaken.

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  • Authors+Show Affiliations

    ,

    Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.

    , , , , , , ,

    Source

    Archives of general psychiatry 62:2 2005 Feb pg 217-24

    MeSH

    Aged
    Alzheimer Disease
    Cross-Sectional Studies
    Dementia
    Female
    Geriatric Assessment
    Humans
    Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Incidence
    Logistic Models
    Longitudinal Studies
    Male
    Neuropsychological Tests
    Prevalence
    Prospective Studies
    Psychiatric Status Rating Scales
    Risk Factors
    Treatment Outcome
    Utah

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15699299

    Citation

    Zandi, Peter P., et al. "Do Statins Reduce Risk of Incident Dementia and Alzheimer Disease? the Cache County Study." Archives of General Psychiatry, vol. 62, no. 2, 2005, pp. 217-24.
    Zandi PP, Sparks DL, Khachaturian AS, et al. Do statins reduce risk of incident dementia and Alzheimer disease? The Cache County Study. Arch Gen Psychiatry. 2005;62(2):217-24.
    Zandi, P. P., Sparks, D. L., Khachaturian, A. S., Tschanz, J., Norton, M., Steinberg, M., ... Breitner, J. C. (2005). Do statins reduce risk of incident dementia and Alzheimer disease? The Cache County Study. Archives of General Psychiatry, 62(2), pp. 217-24.
    Zandi PP, et al. Do Statins Reduce Risk of Incident Dementia and Alzheimer Disease? the Cache County Study. Arch Gen Psychiatry. 2005;62(2):217-24. PubMed PMID: 15699299.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Do statins reduce risk of incident dementia and Alzheimer disease? The Cache County Study. AU - Zandi,Peter P, AU - Sparks,D Larry, AU - Khachaturian,Ara S, AU - Tschanz,Joann, AU - Norton,Maria, AU - Steinberg,Martin, AU - Welsh-Bohmer,Kathleen A, AU - Breitner,John C S, AU - ,, PY - 2005/2/9/pubmed PY - 2005/2/25/medline PY - 2005/2/9/entrez SP - 217 EP - 24 JF - Archives of general psychiatry JO - Arch. Gen. Psychiatry VL - 62 IS - 2 N2 - BACKGROUND: Prior reports suggest reduced occurrence of dementia and Alzheimer disease (AD) in statin users, but, to our knowledge, no prospective studies relate statin use and dementia incidence. OBJECTIVE: To examine the association of statin use with both prevalence and incidence of dementia and AD. DESIGN: Cross-sectional studies of prevalence and incidence and a prospective study of incidence of dementia and AD among 5092 elderly residents (aged 65 years or older) of a single county. Participants were assessed at home in 1995-1997 and again in 1998-2000. A detailed visual inventory of medicines, including statins and other lipid-lowering agents, was collected at both assessments. MAIN OUTCOME MEASURES: Diagnosis of dementia and of AD. RESULTS: From 4895 participants with data sufficient to determine cognitive status, we identified 355 cases of prevalent dementia (200 with AD) at initial assessment. Statin use was inversely associated with prevalence of dementia (adjusted odds ratio, 0.44; 95% confidence interval, 0.17-0.94). Three years later, we identified 185 cases of incident dementia (104 with AD) among 3308 survivors at risk. Statin use at baseline did not predict incidence of dementia or AD (adjusted hazard ratio for dementia, 1.19; 95% confidence interval, 0.53-2.34; adjusted hazard ratio for AD, 1.19; 95% confidence interval, 0.35-2.96), nor did statin use at follow-up (adjusted odds ratio for dementia, 1.04; 95% confidence interval, 0.56-1.81; adjusted odds ratio for AD, 0.85; 95% confidence interval, 0.32-1.88). CONCLUSIONS: Although statin use might be less frequent in those with prevalent dementia, we found no association between statin use and subsequent onset of dementia or AD. Further research is warranted before costly dementia prevention trials with statins are undertaken. SN - 0003-990X UR - https://www.unboundmedicine.com/medline/citation/15699299/Do_statins_reduce_risk_of_incident_dementia_and_Alzheimer_disease_The_Cache_County_Study_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=15699299.ui DB - PRIME DP - Unbound Medicine ER -