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A comparison of donepezil and galantamine in the treatment of cognitive symptoms of Alzheimer's disease: a meta-analysis.
Hum Psychopharmacol. 2005 Apr; 20(3):183-7.HP

Abstract

This review was conducted in order to determine the efficacy of donepezil and galantamine in the treatment of cognitive symptoms of Alzheimer's disease, and also to determine whether galantamine was a superior pharmacological intervention. Meta-analytic methods were used to analyse the data from eight empirical studies which met the inclusion criteria specified. By finding the mean effect sizes of the treatment on the outcome measures of cognition, it was determined that neither drug was greatly efficacious. However, this result does not necessarily diminish the practical value of the drug. It was also found that galantamine was no better than donepezil at treating cognitive decline in AD.

Authors+Show Affiliations

University of Toronto at Scarborough, Toronto, Canada.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

15700322

Citation

Harry, Robin D J., and Konstantine K. Zakzanis. "A Comparison of Donepezil and Galantamine in the Treatment of Cognitive Symptoms of Alzheimer's Disease: a Meta-analysis." Human Psychopharmacology, vol. 20, no. 3, 2005, pp. 183-7.
Harry RD, Zakzanis KK. A comparison of donepezil and galantamine in the treatment of cognitive symptoms of Alzheimer's disease: a meta-analysis. Hum Psychopharmacol. 2005;20(3):183-7.
Harry, R. D., & Zakzanis, K. K. (2005). A comparison of donepezil and galantamine in the treatment of cognitive symptoms of Alzheimer's disease: a meta-analysis. Human Psychopharmacology, 20(3), 183-7.
Harry RD, Zakzanis KK. A Comparison of Donepezil and Galantamine in the Treatment of Cognitive Symptoms of Alzheimer's Disease: a Meta-analysis. Hum Psychopharmacol. 2005;20(3):183-7. PubMed PMID: 15700322.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of donepezil and galantamine in the treatment of cognitive symptoms of Alzheimer's disease: a meta-analysis. AU - Harry,Robin D J, AU - Zakzanis,Konstantine K, PY - 2005/2/9/pubmed PY - 2005/7/28/medline PY - 2005/2/9/entrez SP - 183 EP - 7 JF - Human psychopharmacology JO - Hum Psychopharmacol VL - 20 IS - 3 N2 - This review was conducted in order to determine the efficacy of donepezil and galantamine in the treatment of cognitive symptoms of Alzheimer's disease, and also to determine whether galantamine was a superior pharmacological intervention. Meta-analytic methods were used to analyse the data from eight empirical studies which met the inclusion criteria specified. By finding the mean effect sizes of the treatment on the outcome measures of cognition, it was determined that neither drug was greatly efficacious. However, this result does not necessarily diminish the practical value of the drug. It was also found that galantamine was no better than donepezil at treating cognitive decline in AD. SN - 0885-6222 UR - https://www.unboundmedicine.com/medline/citation/15700322/A_comparison_of_donepezil_and_galantamine_in_the_treatment_of_cognitive_symptoms_of_Alzheimer's_disease:_a_meta_analysis_ L2 - https://doi.org/10.1002/hup.676 DB - PRIME DP - Unbound Medicine ER -