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[The prevalence of hepatitis G virus in patients with hepatitis B and C virus infections].
Mikrobiyol Bul. 2004 Oct; 38(4):421-7.MB

Abstract

GB virus C/hepatitis G virus (GBV-C/HGV) is a recently identified flavivirus, which has been frequently detected in patients with chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. In this study, the prevalence of HGV-RNA and antibodies to E2 envelope antigen (anti-E2) which is a marker of past infection, have been investigated in the samples of patients with HCV and HBV infections, and the prevalence rates were compared with the control group. The study group consisted of 50 patients with HBV and 50 patients with HCV infections, who did not have any risk for parenteral transmission, and 60 healthy control subjects. Serum samples were tested for the presence of HGV-RNA by real time polymerase chain reaction (PCR) and for anti-E2 by a commercial enzyme-linked immunosorbent assay (ELISA). As a result, HGV-RNA and anti-HGV-E2 positivity rates in HBV and HCV infected patients were found as; 4% and 6%, 4% and 4%, respectively. Although the prevalence of HGV-RNA in patients with HBV and HCV infections were higher than the control group (1.66%), there was no statistically significant difference (p>0.05). The prevalence of anti-E2 antibodies in patients with HBV and HCV infections did not revealed any difference in comparison to the control group (6.66%) (p>0.05). In conclusion, GBV-C/HGV infection prevalence was found low in patients with HBV and HCV infections, supporting that although parenteral route is the most effective way, other routes such as sexual contact and intra-familial contact may also play role in HGV transmission.

Authors+Show Affiliations

Süleyman Demirel Universitesi Tip Fakültesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dali, Isparta.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

tur

PubMed ID

15700668

Citation

Kaya, Selçuk, et al. "[The Prevalence of Hepatitis G Virus in Patients With Hepatitis B and C Virus Infections]." Mikrobiyoloji Bulteni, vol. 38, no. 4, 2004, pp. 421-7.
Kaya S, Cicioğlu Aridoğan B, Demirci M. [The prevalence of hepatitis G virus in patients with hepatitis B and C virus infections]. Mikrobiyol Bul. 2004;38(4):421-7.
Kaya, S., Cicioğlu Aridoğan, B., & Demirci, M. (2004). [The prevalence of hepatitis G virus in patients with hepatitis B and C virus infections]. Mikrobiyoloji Bulteni, 38(4), 421-7.
Kaya S, Cicioğlu Aridoğan B, Demirci M. [The Prevalence of Hepatitis G Virus in Patients With Hepatitis B and C Virus Infections]. Mikrobiyol Bul. 2004;38(4):421-7. PubMed PMID: 15700668.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The prevalence of hepatitis G virus in patients with hepatitis B and C virus infections]. AU - Kaya,Selçuk, AU - Cicioğlu Aridoğan,Buket, AU - Demirci,Mustafa, PY - 2005/2/11/pubmed PY - 2005/8/23/medline PY - 2005/2/11/entrez SP - 421 EP - 7 JF - Mikrobiyoloji bulteni JO - Mikrobiyol Bul VL - 38 IS - 4 N2 - GB virus C/hepatitis G virus (GBV-C/HGV) is a recently identified flavivirus, which has been frequently detected in patients with chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. In this study, the prevalence of HGV-RNA and antibodies to E2 envelope antigen (anti-E2) which is a marker of past infection, have been investigated in the samples of patients with HCV and HBV infections, and the prevalence rates were compared with the control group. The study group consisted of 50 patients with HBV and 50 patients with HCV infections, who did not have any risk for parenteral transmission, and 60 healthy control subjects. Serum samples were tested for the presence of HGV-RNA by real time polymerase chain reaction (PCR) and for anti-E2 by a commercial enzyme-linked immunosorbent assay (ELISA). As a result, HGV-RNA and anti-HGV-E2 positivity rates in HBV and HCV infected patients were found as; 4% and 6%, 4% and 4%, respectively. Although the prevalence of HGV-RNA in patients with HBV and HCV infections were higher than the control group (1.66%), there was no statistically significant difference (p>0.05). The prevalence of anti-E2 antibodies in patients with HBV and HCV infections did not revealed any difference in comparison to the control group (6.66%) (p>0.05). In conclusion, GBV-C/HGV infection prevalence was found low in patients with HBV and HCV infections, supporting that although parenteral route is the most effective way, other routes such as sexual contact and intra-familial contact may also play role in HGV transmission. SN - 0374-9096 UR - https://www.unboundmedicine.com/medline/citation/15700668/[The_prevalence_of_hepatitis_G_virus_in_patients_with_hepatitis_B_and_C_virus_infections]_ L2 - http://www.diseaseinfosearch.org/result/3332 DB - PRIME DP - Unbound Medicine ER -