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Duration of untreated psychosis and outcome in first-episode psychosis. Perspective from a developing country.
Acta Psychiatr Scand. 2005 Mar; 111(3):214-9.AP

Abstract

OBJECTIVE

To investigate the association between duration of untreated psychosis (DUP) and treatment outcome in a sample of subjects from a developing country.

METHOD

Forty-eight subjects with a first episode of psychosis were evaluated prior to treatment and at 3-month intervals over a period of 24 months. We first examined correlations between DUP and symptom improvement as measured on the Positive and Negative Symptom Scale (PANSS), and then performed multivariate analysis to determine the validity of DUP as a predictor of outcome.

RESULTS

DUP was significantly correlated with improvement in PANSS total and negative subscale scores as well as the PANSS depression factor at 21 and 24 months. Multivariate analysis found DUP to be the only significant predictor of improvement in negative symptoms at 24 months.

CONCLUSION

DUP was a significant predictor of outcome in a cohort form a developing country. This study provides support for early detection and intervention strategies.

Authors+Show Affiliations

Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa. pieto@sun.ac.zaNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15701106

Citation

Oosthuizen, P, et al. "Duration of Untreated Psychosis and Outcome in First-episode Psychosis. Perspective From a Developing Country." Acta Psychiatrica Scandinavica, vol. 111, no. 3, 2005, pp. 214-9.
Oosthuizen P, Emsley RA, Keyter N, et al. Duration of untreated psychosis and outcome in first-episode psychosis. Perspective from a developing country. Acta Psychiatr Scand. 2005;111(3):214-9.
Oosthuizen, P., Emsley, R. A., Keyter, N., Niehaus, D. J., & Koen, L. (2005). Duration of untreated psychosis and outcome in first-episode psychosis. Perspective from a developing country. Acta Psychiatrica Scandinavica, 111(3), 214-9.
Oosthuizen P, et al. Duration of Untreated Psychosis and Outcome in First-episode Psychosis. Perspective From a Developing Country. Acta Psychiatr Scand. 2005;111(3):214-9. PubMed PMID: 15701106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Duration of untreated psychosis and outcome in first-episode psychosis. Perspective from a developing country. AU - Oosthuizen,P, AU - Emsley,R A, AU - Keyter,N, AU - Niehaus,D J H, AU - Koen,L, PY - 2005/2/11/pubmed PY - 2005/6/24/medline PY - 2005/2/11/entrez SP - 214 EP - 9 JF - Acta psychiatrica Scandinavica JO - Acta Psychiatr Scand VL - 111 IS - 3 N2 - OBJECTIVE: To investigate the association between duration of untreated psychosis (DUP) and treatment outcome in a sample of subjects from a developing country. METHOD: Forty-eight subjects with a first episode of psychosis were evaluated prior to treatment and at 3-month intervals over a period of 24 months. We first examined correlations between DUP and symptom improvement as measured on the Positive and Negative Symptom Scale (PANSS), and then performed multivariate analysis to determine the validity of DUP as a predictor of outcome. RESULTS: DUP was significantly correlated with improvement in PANSS total and negative subscale scores as well as the PANSS depression factor at 21 and 24 months. Multivariate analysis found DUP to be the only significant predictor of improvement in negative symptoms at 24 months. CONCLUSION: DUP was a significant predictor of outcome in a cohort form a developing country. This study provides support for early detection and intervention strategies. SN - 0001-690X UR - https://www.unboundmedicine.com/medline/citation/15701106/Duration_of_untreated_psychosis_and_outcome_in_first_episode_psychosis__Perspective_from_a_developing_country_ L2 - https://doi.org/10.1111/j.1600-0447.2004.00448.x DB - PRIME DP - Unbound Medicine ER -