Tags

Type your tag names separated by a space and hit enter

No evidence for germline mutations in exons 5-9 of the p53 gene in 25 breast cancer families.
Oncogene 1992; 7(5):1043-6O

Abstract

Recent studies have demonstrated that families with the Li-Fraumeni syndrome carry inherited point mutations of the p53 gene. In the present study 25 families with strong histories of breast cancer were screened for the presence of such mutations. Polymerase chain reaction products of exons 5-9 of the p53 gene were examined by single-stranded conformational polymorphism analysis and, in addition, exon 7 was further screened by direct sequencing. No mutations were detected in constitutive DNA by either method. These results indicate that familial breast cancer does not usually result from germline point mutations in the p53 gene.

Authors+Show Affiliations

Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1570151

Citation

Warren, W, et al. "No Evidence for Germline Mutations in Exons 5-9 of the P53 Gene in 25 Breast Cancer Families." Oncogene, vol. 7, no. 5, 1992, pp. 1043-6.
Warren W, Eeles RA, Ponder BA, et al. No evidence for germline mutations in exons 5-9 of the p53 gene in 25 breast cancer families. Oncogene. 1992;7(5):1043-6.
Warren, W., Eeles, R. A., Ponder, B. A., Easton, D. F., Averill, D., Ponder, M. A., ... Love, R. (1992). No evidence for germline mutations in exons 5-9 of the p53 gene in 25 breast cancer families. Oncogene, 7(5), pp. 1043-6.
Warren W, et al. No Evidence for Germline Mutations in Exons 5-9 of the P53 Gene in 25 Breast Cancer Families. Oncogene. 1992;7(5):1043-6. PubMed PMID: 1570151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No evidence for germline mutations in exons 5-9 of the p53 gene in 25 breast cancer families. A1 - Warren,W, AU - Eeles,R A, AU - Ponder,B A, AU - Easton,D F, AU - Averill,D, AU - Ponder,M A, AU - Anderson,K, AU - Evans,A M, AU - DeMars,R, AU - Love,R, PY - 1992/5/1/pubmed PY - 1992/5/1/medline PY - 1992/5/1/entrez SP - 1043 EP - 6 JF - Oncogene JO - Oncogene VL - 7 IS - 5 N2 - Recent studies have demonstrated that families with the Li-Fraumeni syndrome carry inherited point mutations of the p53 gene. In the present study 25 families with strong histories of breast cancer were screened for the presence of such mutations. Polymerase chain reaction products of exons 5-9 of the p53 gene were examined by single-stranded conformational polymorphism analysis and, in addition, exon 7 was further screened by direct sequencing. No mutations were detected in constitutive DNA by either method. These results indicate that familial breast cancer does not usually result from germline point mutations in the p53 gene. SN - 0950-9232 UR - https://www.unboundmedicine.com/medline/citation/1570151/No_evidence_for_germline_mutations_in_exons_5_9_of_the_p53_gene_in_25_breast_cancer_families_ L2 - http://www.diseaseinfosearch.org/result/960 DB - PRIME DP - Unbound Medicine ER -