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[Free radicals in clinical biology. Origin, pathogenic effect and defense mechanisms].
Pathol Biol (Paris) 1992; 40(1):66-77PB

Abstract

Free radicals are chemical species with an unpaired electron on their outer orbit. This review discusses the various endogenous and exogenous sources of free radicals; toxicity of free radicals, especially for DNA and cell membranes; a number of pathophysiologic states related to overproduction of free radicals; the natural protective systems--involving enzymes or scavengers--which prevent free radical-induced cell injury, and therapeutic trials of antioxidants for improving protection against free radicals in a number of conditions.

Authors+Show Affiliations

Laboratoire de Biochimie, Hôpital Corentin Celton, Issy-Les-Moulineaux, France.No affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

1570186

Citation

Fulbert, J C., and M J. Cals. "[Free Radicals in Clinical Biology. Origin, Pathogenic Effect and Defense Mechanisms]." Pathologie-biologie, vol. 40, no. 1, 1992, pp. 66-77.
Fulbert JC, Cals MJ. [Free radicals in clinical biology. Origin, pathogenic effect and defense mechanisms]. Pathol Biol. 1992;40(1):66-77.
Fulbert, J. C., & Cals, M. J. (1992). [Free radicals in clinical biology. Origin, pathogenic effect and defense mechanisms]. Pathologie-biologie, 40(1), pp. 66-77.
Fulbert JC, Cals MJ. [Free Radicals in Clinical Biology. Origin, Pathogenic Effect and Defense Mechanisms]. Pathol Biol. 1992;40(1):66-77. PubMed PMID: 1570186.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Free radicals in clinical biology. Origin, pathogenic effect and defense mechanisms]. AU - Fulbert,J C, AU - Cals,M J, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 66 EP - 77 JF - Pathologie-biologie JO - Pathol. Biol. VL - 40 IS - 1 N2 - Free radicals are chemical species with an unpaired electron on their outer orbit. This review discusses the various endogenous and exogenous sources of free radicals; toxicity of free radicals, especially for DNA and cell membranes; a number of pathophysiologic states related to overproduction of free radicals; the natural protective systems--involving enzymes or scavengers--which prevent free radical-induced cell injury, and therapeutic trials of antioxidants for improving protection against free radicals in a number of conditions. SN - 0369-8114 UR - https://www.unboundmedicine.com/medline/citation/1570186/[Free_radicals_in_clinical_biology__Origin_pathogenic_effect_and_defense_mechanisms]_ DB - PRIME DP - Unbound Medicine ER -