Tags

Type your tag names separated by a space and hit enter

A low pulse pressure is an independent predictor of mortality in heart failure: data from a large nationwide cardiology database (IN-CHF Registry).
Ital Heart J 2004; 5(12):892-8IH

Abstract

BACKGROUND

A high pulse pressure (PP) predicts cardiovascular mortality in hypertension and in the elderly. We analyzed the data from the Italian Network of Congestive Heart Failure Registry to test the prognostic role of PP in patients with heart failure.

METHODS

A total of 8660 patients with heart failure (mean age 64 +/- 12 years, 73% male) were divided into four groups according to their PP (< 40, 40-49, 50-59, and > or = 60 mmHg), and followed prospectively.

RESULTS

After 1 year, 995 patients (11.5%) died. Both the mean arterial pressure and systolic blood pressure were found to be inversely associated with mortality at univariate and multivariate analyses. An inverse univariate relation was observed between PP and all-cause mortality. An excess mortality risk in the lowest PP group (odds ratio 1.40, 95% confidence interval 1.09-1.79 vs the highest PP group) was confirmed in a multivariate analysis which took into account the effect of several other variables, including mean arterial pressure. Similar findings were obtained for cardiovascular mortality. When we replaced systolic blood pressure with mean arterial pressure in the model, PP did not retain its independent prognostic role, possibly because of the high co-linearity between these two variables (r = 0.87).

CONCLUSIONS

For any given level of mean arterial pressure, a low PP is an independent predictor of all-cause and cardiovascular death in patients with heart failure. The association may be partly related to the strong influence of low systolic blood pressure on mortality. Different pathophysiological mechanisms may underlie the opposite prognostic significance of PP in hypertension and heart failure.

Authors+Show Affiliations

Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15706993

Citation

Schillaci, Giuseppe, et al. "A Low Pulse Pressure Is an Independent Predictor of Mortality in Heart Failure: Data From a Large Nationwide Cardiology Database (IN-CHF Registry)." Italian Heart Journal : Official Journal of the Italian Federation of Cardiology, vol. 5, no. 12, 2004, pp. 892-8.
Schillaci G, Di Luzio S, Coluccini M, et al. A low pulse pressure is an independent predictor of mortality in heart failure: data from a large nationwide cardiology database (IN-CHF Registry). Ital Heart J. 2004;5(12):892-8.
Schillaci, G., Di Luzio, S., Coluccini, M., Gonzini, L., Porcu, M., Pozzar, F., & Maggioni, A. P. (2004). A low pulse pressure is an independent predictor of mortality in heart failure: data from a large nationwide cardiology database (IN-CHF Registry). Italian Heart Journal : Official Journal of the Italian Federation of Cardiology, 5(12), pp. 892-8.
Schillaci G, et al. A Low Pulse Pressure Is an Independent Predictor of Mortality in Heart Failure: Data From a Large Nationwide Cardiology Database (IN-CHF Registry). Ital Heart J. 2004;5(12):892-8. PubMed PMID: 15706993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A low pulse pressure is an independent predictor of mortality in heart failure: data from a large nationwide cardiology database (IN-CHF Registry). AU - Schillaci,Giuseppe, AU - Di Luzio,Silvia, AU - Coluccini,Mario, AU - Gonzini,Lucio, AU - Porcu,Maurizio, AU - Pozzar,Francesco, AU - Maggioni,Aldo P, AU - ,, PY - 2005/2/15/pubmed PY - 2005/5/18/medline PY - 2005/2/15/entrez SP - 892 EP - 8 JF - Italian heart journal : official journal of the Italian Federation of Cardiology JO - Ital Heart J VL - 5 IS - 12 N2 - BACKGROUND: A high pulse pressure (PP) predicts cardiovascular mortality in hypertension and in the elderly. We analyzed the data from the Italian Network of Congestive Heart Failure Registry to test the prognostic role of PP in patients with heart failure. METHODS: A total of 8660 patients with heart failure (mean age 64 +/- 12 years, 73% male) were divided into four groups according to their PP (< 40, 40-49, 50-59, and > or = 60 mmHg), and followed prospectively. RESULTS: After 1 year, 995 patients (11.5%) died. Both the mean arterial pressure and systolic blood pressure were found to be inversely associated with mortality at univariate and multivariate analyses. An inverse univariate relation was observed between PP and all-cause mortality. An excess mortality risk in the lowest PP group (odds ratio 1.40, 95% confidence interval 1.09-1.79 vs the highest PP group) was confirmed in a multivariate analysis which took into account the effect of several other variables, including mean arterial pressure. Similar findings were obtained for cardiovascular mortality. When we replaced systolic blood pressure with mean arterial pressure in the model, PP did not retain its independent prognostic role, possibly because of the high co-linearity between these two variables (r = 0.87). CONCLUSIONS: For any given level of mean arterial pressure, a low PP is an independent predictor of all-cause and cardiovascular death in patients with heart failure. The association may be partly related to the strong influence of low systolic blood pressure on mortality. Different pathophysiological mechanisms may underlie the opposite prognostic significance of PP in hypertension and heart failure. SN - 1129-471X UR - https://www.unboundmedicine.com/medline/citation/15706993/A_low_pulse_pressure_is_an_independent_predictor_of_mortality_in_heart_failure:_data_from_a_large_nationwide_cardiology_database__IN_CHF_Registry__ L2 - https://medlineplus.gov/heartfailure.html DB - PRIME DP - Unbound Medicine ER -