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Antibacterial activity of an eudesmane sesquiterpene isolated from common Varthemia, Varthemia iphionoides.
J Ethnopharmacol. 2005 Feb 28; 97(2):237-40.JE

Abstract

The ethyl acetate extract of the whole aerial parts of Varthemia iphionoides (Compositae) showed a pronounced antibacterial activity. The bioassay-guided fractionation of the ethyl acetate extract and further purification of the most antibacterially active fraction led to the isolation and identification of an antibacterial sesquiterpene, selina-4,11(13)-dien-3-on-12-oic acid. This compound exhibited potent antimicrobial activity against six bacterial species (Staphylococcus aureus, Bacillus subtilis, Micrococcus luteus, Escherichia coli, Bacillus cereus and Salmonella enteritides). The minimum inhibitory concentrations (MICs) of this compound which was determined by the agar dilution method ranged between 250 and 500 microg/ml.

Authors+Show Affiliations

Al-Dabbas MM
Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan.
Hashinaga F
No affiliation info available
Abdelgaleil SA
No affiliation info available
Suganuma T
No affiliation info available
Akiyama K
No affiliation info available
Hayashi H
No affiliation info available

MeSH

Anti-Bacterial AgentsAsteraceaeBacteriaMicrobial Sensitivity TestsPlant ExtractsSesquiterpenesSesquiterpenes, Eudesmane

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15707759

Citation

Al-Dabbas, Maher M., et al. "Antibacterial Activity of an Eudesmane Sesquiterpene Isolated From Common Varthemia, Varthemia Iphionoides." Journal of Ethnopharmacology, vol. 97, no. 2, 2005, pp. 237-40.
Al-Dabbas MM, Hashinaga F, Abdelgaleil SA, et al. Antibacterial activity of an eudesmane sesquiterpene isolated from common Varthemia, Varthemia iphionoides. J Ethnopharmacol. 2005;97(2):237-40.
Al-Dabbas, M. M., Hashinaga, F., Abdelgaleil, S. A., Suganuma, T., Akiyama, K., & Hayashi, H. (2005). Antibacterial activity of an eudesmane sesquiterpene isolated from common Varthemia, Varthemia iphionoides. Journal of Ethnopharmacology, 97(2), 237-40.
Al-Dabbas MM, et al. Antibacterial Activity of an Eudesmane Sesquiterpene Isolated From Common Varthemia, Varthemia Iphionoides. J Ethnopharmacol. 2005 Feb 28;97(2):237-40. PubMed PMID: 15707759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibacterial activity of an eudesmane sesquiterpene isolated from common Varthemia, Varthemia iphionoides. AU - Al-Dabbas,Maher M, AU - Hashinaga,Fumio, AU - Abdelgaleil,Samir A M, AU - Suganuma,Toshihiko, AU - Akiyama,Kohki, AU - Hayashi,Hideo, Y1 - 2004/12/29/ PY - 2004/05/06/received PY - 2004/10/06/revised PY - 2004/11/08/accepted PY - 2005/2/15/pubmed PY - 2005/6/14/medline PY - 2005/2/15/entrez SP - 237 EP - 40 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 97 IS - 2 N2 - The ethyl acetate extract of the whole aerial parts of Varthemia iphionoides (Compositae) showed a pronounced antibacterial activity. The bioassay-guided fractionation of the ethyl acetate extract and further purification of the most antibacterially active fraction led to the isolation and identification of an antibacterial sesquiterpene, selina-4,11(13)-dien-3-on-12-oic acid. This compound exhibited potent antimicrobial activity against six bacterial species (Staphylococcus aureus, Bacillus subtilis, Micrococcus luteus, Escherichia coli, Bacillus cereus and Salmonella enteritides). The minimum inhibitory concentrations (MICs) of this compound which was determined by the agar dilution method ranged between 250 and 500 microg/ml. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/15707759/Antibacterial_activity_of_an_eudesmane_sesquiterpene_isolated_from_common_Varthemia_Varthemia_iphionoides_ DB - PRIME DP - Unbound Medicine ER -