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Acute effects of caffeine on blood pressure and wave reflections in healthy subjects: should we consider monitoring central blood pressure?

Abstract

BACKGROUND

Data concerning blood pressure changes, acutely induced by caffeine consumption, are conflicting. Furthermore, limited data exist regarding central hemodynamic response to caffeine ingestion by healthy young subjects. We investigated the acute effect of coffee (80 mg of caffeine) and decaffeinated coffee on peripheral and central hemodynamics, as well as on wave reflections.

SUBJECTS

For this purpose, 16 healthy volunteers (eight females and eight males, mean age 29+/-3.2 years) were investigated.

METHODS

Repeated measurements were performed at baseline and 30, 60, 90 and 120 min after oral administration of each beverage in a double-blind crossover design. Aortic blood pressures, augmentation index (AI) and pressure (AP) and timing of reflected waves were evaluated by using applanation tonometry and pulse wave analysis.

RESULTS

Regular coffee increased central systolic (SBP) and diastolic pressure (DBP) from 96.2+/-9.9 to 101.1+/-10.1 mmHg, p=0.011 and from 72.6+/-9.4 to 76.5+/-9.0 mmHg, p=0.027, respectively, but no change was observed following consumption of decaffeinated coffee. Peripheral systolic blood pressure did not change significantly after the administration of either coffee. Augmentation index increased significantly following regular coffee consumption. The change in AI was significantly higher following regular compared to decaffeinated coffee consumption as shown by analysis of variance (ANOVA) for repeated measures (p=0.001).

CONCLUSIONS

These caffeine effects reveal an unfavourable effect on wave reflections and therefore on left ventricular (LV) pulsatile afterload. It also revealed a significant acute effect of caffeine consumption on central hemodynamics which is not observed at peripheral pressures.

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  • Authors+Show Affiliations

    ,

    Vascular Laboratory, Department of Clinical Therapeutics, "Alexandra" Hospital, National and Kapodistrian University of Athens, Greece.

    , , , , , , ,

    Source

    International journal of cardiology 98:3 2005 Feb 28 pg 425-30

    MeSH

    Adult
    Arteries
    Blood Pressure
    Blood Pressure Monitoring, Ambulatory
    Caffeine
    Central Nervous System Stimulants
    Cross-Over Studies
    Double-Blind Method
    Female
    Hemodynamics
    Humans
    Male
    Ventricular Function, Left

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    15708175

    Citation

    Karatzis, Emmanouil, et al. "Acute Effects of Caffeine On Blood Pressure and Wave Reflections in Healthy Subjects: Should We Consider Monitoring Central Blood Pressure?" International Journal of Cardiology, vol. 98, no. 3, 2005, pp. 425-30.
    Karatzis E, Papaioannou TG, Aznaouridis K, et al. Acute effects of caffeine on blood pressure and wave reflections in healthy subjects: should we consider monitoring central blood pressure? Int J Cardiol. 2005;98(3):425-30.
    Karatzis, E., Papaioannou, T. G., Aznaouridis, K., Karatzi, K., Stamatelopoulos, K., Zampelas, A., ... Mavrikakis, M. (2005). Acute effects of caffeine on blood pressure and wave reflections in healthy subjects: should we consider monitoring central blood pressure? International Journal of Cardiology, 98(3), pp. 425-30.
    Karatzis E, et al. Acute Effects of Caffeine On Blood Pressure and Wave Reflections in Healthy Subjects: Should We Consider Monitoring Central Blood Pressure. Int J Cardiol. 2005 Feb 28;98(3):425-30. PubMed PMID: 15708175.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Acute effects of caffeine on blood pressure and wave reflections in healthy subjects: should we consider monitoring central blood pressure? AU - Karatzis,Emmanouil, AU - Papaioannou,Theodore G, AU - Aznaouridis,Konstantinos, AU - Karatzi,Kalliopi, AU - Stamatelopoulos,Kimon, AU - Zampelas,Antonios, AU - Papamichael,Christos, AU - Lekakis,John, AU - Mavrikakis,Myron, PY - 2003/07/17/received PY - 2003/11/22/revised PY - 2003/11/23/accepted PY - 2005/2/15/pubmed PY - 2005/6/17/medline PY - 2005/2/15/entrez SP - 425 EP - 30 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 98 IS - 3 N2 - BACKGROUND: Data concerning blood pressure changes, acutely induced by caffeine consumption, are conflicting. Furthermore, limited data exist regarding central hemodynamic response to caffeine ingestion by healthy young subjects. We investigated the acute effect of coffee (80 mg of caffeine) and decaffeinated coffee on peripheral and central hemodynamics, as well as on wave reflections. SUBJECTS: For this purpose, 16 healthy volunteers (eight females and eight males, mean age 29+/-3.2 years) were investigated. METHODS: Repeated measurements were performed at baseline and 30, 60, 90 and 120 min after oral administration of each beverage in a double-blind crossover design. Aortic blood pressures, augmentation index (AI) and pressure (AP) and timing of reflected waves were evaluated by using applanation tonometry and pulse wave analysis. RESULTS: Regular coffee increased central systolic (SBP) and diastolic pressure (DBP) from 96.2+/-9.9 to 101.1+/-10.1 mmHg, p=0.011 and from 72.6+/-9.4 to 76.5+/-9.0 mmHg, p=0.027, respectively, but no change was observed following consumption of decaffeinated coffee. Peripheral systolic blood pressure did not change significantly after the administration of either coffee. Augmentation index increased significantly following regular coffee consumption. The change in AI was significantly higher following regular compared to decaffeinated coffee consumption as shown by analysis of variance (ANOVA) for repeated measures (p=0.001). CONCLUSIONS: These caffeine effects reveal an unfavourable effect on wave reflections and therefore on left ventricular (LV) pulsatile afterload. It also revealed a significant acute effect of caffeine consumption on central hemodynamics which is not observed at peripheral pressures. SN - 0167-5273 UR - https://www.unboundmedicine.com/medline/citation/15708175/Acute_effects_of_caffeine_on_blood_pressure_and_wave_reflections_in_healthy_subjects:_should_we_consider_monitoring_central_blood_pressure L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167527304001172 DB - PRIME DP - Unbound Medicine ER -