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Serotonergic modulation of mismatch negativity.
Psychiatry Res 2005; 138(1):61-74PR

Abstract

Neurochemical mechanisms mediating the interaction between emotional and cognitive processing are not yet fully understood. Here, we utilized acute tryptophan depletion (ATD) to reduce the brain synthesis of serotonin (5-HT), which is thought to have a central role in regulation of emotions and mood in humans. ATD effects on event-related potentials and magnetic fields were studied using a passive odd-ball paradigm in a randomized, double-blinded, controlled, cross-over design. Auditory responses were recorded simultaneously with high-resolution magnetoencephalography (MEG) and electroencephalography (EEG) in 14 healthy subjects, 5 h after ATD or a control condition. ATD significantly increased depressed mood and lowered plasma tryptophan concentration (total tryptophan decreased by 75%, free tryptophan decreased by 39%). As compared with the control condition, ATD increased the amplitudes of mismatch negativity (MMN) to duration and frequency changes and decreased the latencies of magnetic MMN to frequency changes in the hemisphere ipsilateral to the ear stimulated. Further, ATD modulated N1m latencies and decreased P2m source activity. ATD increased the interhemispheric latency difference of MMNm to frequency changes. No effects on P50 were observed. The present results suggest serotonergic modulation of preattentive auditory change detection, suggested to initiate involuntary attention shifting in the human brain.

Authors+Show Affiliations

Cognitive Brain Research Unit, University of Helsinki, Finland. seppo.kahkonen@helsinki.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15708302

Citation

Kähkönen, Seppo, et al. "Serotonergic Modulation of Mismatch Negativity." Psychiatry Research, vol. 138, no. 1, 2005, pp. 61-74.
Kähkönen S, Mäkinen V, Jääskeläinen IP, et al. Serotonergic modulation of mismatch negativity. Psychiatry Res. 2005;138(1):61-74.
Kähkönen, S., Mäkinen, V., Jääskeläinen, I. P., Pennanen, S., Liesivuori, J., & Ahveninen, J. (2005). Serotonergic modulation of mismatch negativity. Psychiatry Research, 138(1), pp. 61-74.
Kähkönen S, et al. Serotonergic Modulation of Mismatch Negativity. Psychiatry Res. 2005 Jan 30;138(1):61-74. PubMed PMID: 15708302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serotonergic modulation of mismatch negativity. AU - Kähkönen,Seppo, AU - Mäkinen,Ville, AU - Jääskeläinen,Iiro P, AU - Pennanen,Sirpa, AU - Liesivuori,Jyrki, AU - Ahveninen,Jyrki, PY - 2003/09/16/received PY - 2004/08/12/revised PY - 2004/09/20/accepted PY - 2005/2/15/pubmed PY - 2005/4/27/medline PY - 2005/2/15/entrez SP - 61 EP - 74 JF - Psychiatry research JO - Psychiatry Res VL - 138 IS - 1 N2 - Neurochemical mechanisms mediating the interaction between emotional and cognitive processing are not yet fully understood. Here, we utilized acute tryptophan depletion (ATD) to reduce the brain synthesis of serotonin (5-HT), which is thought to have a central role in regulation of emotions and mood in humans. ATD effects on event-related potentials and magnetic fields were studied using a passive odd-ball paradigm in a randomized, double-blinded, controlled, cross-over design. Auditory responses were recorded simultaneously with high-resolution magnetoencephalography (MEG) and electroencephalography (EEG) in 14 healthy subjects, 5 h after ATD or a control condition. ATD significantly increased depressed mood and lowered plasma tryptophan concentration (total tryptophan decreased by 75%, free tryptophan decreased by 39%). As compared with the control condition, ATD increased the amplitudes of mismatch negativity (MMN) to duration and frequency changes and decreased the latencies of magnetic MMN to frequency changes in the hemisphere ipsilateral to the ear stimulated. Further, ATD modulated N1m latencies and decreased P2m source activity. ATD increased the interhemispheric latency difference of MMNm to frequency changes. No effects on P50 were observed. The present results suggest serotonergic modulation of preattentive auditory change detection, suggested to initiate involuntary attention shifting in the human brain. SN - 0165-1781 UR - https://www.unboundmedicine.com/medline/citation/15708302/Serotonergic_modulation_of_mismatch_negativity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0925-4927(04)00155-6 DB - PRIME DP - Unbound Medicine ER -