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Solar radiation, vitamin D and survival rate of colon cancer in Norway.
J Photochem Photobiol B. 2005 Mar 01; 78(3):189-93.JP

Abstract

Solar radiation contributes significantly to the status of serum calcidiol (25-hydroxyvitamin D3, 25-(OH)D3) in humans, even at the high latitudes of northern Norway. Thus, in late summer the serum concentration of calcidiol is roughly 50% larger than that in late winter, when the solar radiation in Norway contains too little ultraviolet radiation to induce any synthesis of vitamin D3 in human skin. This seems to influence the prognosis of colon cancer. We here report that the survival rate of colon cancer in men and women, assessed 18 months after diagnosis, is dependent on the season of diagnosis. A high serum concentration of calcidiol at the time of diagnosis, i.e. at the start of conventional therapy, seems to give an increased survival rate. This agrees with cell and animal experiments reported in the literature, as well as with epidemiological data from some countries relating colon cancer survival with latitude and vitamin D3 synthesis in skin. One possible interpretation of the present data is that, the level of calcidiol, or its derivative calcitriol (1alpha,25-dihydroxyvitamin D3, 1alpha,25-(OH)2D3), may act positively in concert with conventional therapies of colon cancer.

Authors+Show Affiliations

Avdeling for strålingsbiologi, Institutt for kreftforskning, Montebello, N-0310 Oslo, Norway. johan.moan@labmed.uio.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15708515

Citation

Moan, Johan, et al. "Solar Radiation, Vitamin D and Survival Rate of Colon Cancer in Norway." Journal of Photochemistry and Photobiology. B, Biology, vol. 78, no. 3, 2005, pp. 189-93.
Moan J, Porojnicu AC, Robsahm TE, et al. Solar radiation, vitamin D and survival rate of colon cancer in Norway. J Photochem Photobiol B. 2005;78(3):189-93.
Moan, J., Porojnicu, A. C., Robsahm, T. E., Dahlback, A., Juzeniene, A., Tretli, S., & Grant, W. (2005). Solar radiation, vitamin D and survival rate of colon cancer in Norway. Journal of Photochemistry and Photobiology. B, Biology, 78(3), 189-93.
Moan J, et al. Solar Radiation, Vitamin D and Survival Rate of Colon Cancer in Norway. J Photochem Photobiol B. 2005 Mar 1;78(3):189-93. PubMed PMID: 15708515.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Solar radiation, vitamin D and survival rate of colon cancer in Norway. AU - Moan,Johan, AU - Porojnicu,Alina Carmen, AU - Robsahm,Trude Eid, AU - Dahlback,Arne, AU - Juzeniene,Asta, AU - Tretli,Steinar, AU - Grant,William, PY - 2004/09/30/received PY - 2004/10/11/revised PY - 2004/11/11/accepted PY - 2005/2/15/pubmed PY - 2005/8/9/medline PY - 2005/2/15/entrez SP - 189 EP - 93 JF - Journal of photochemistry and photobiology. B, Biology JO - J Photochem Photobiol B VL - 78 IS - 3 N2 - Solar radiation contributes significantly to the status of serum calcidiol (25-hydroxyvitamin D3, 25-(OH)D3) in humans, even at the high latitudes of northern Norway. Thus, in late summer the serum concentration of calcidiol is roughly 50% larger than that in late winter, when the solar radiation in Norway contains too little ultraviolet radiation to induce any synthesis of vitamin D3 in human skin. This seems to influence the prognosis of colon cancer. We here report that the survival rate of colon cancer in men and women, assessed 18 months after diagnosis, is dependent on the season of diagnosis. A high serum concentration of calcidiol at the time of diagnosis, i.e. at the start of conventional therapy, seems to give an increased survival rate. This agrees with cell and animal experiments reported in the literature, as well as with epidemiological data from some countries relating colon cancer survival with latitude and vitamin D3 synthesis in skin. One possible interpretation of the present data is that, the level of calcidiol, or its derivative calcitriol (1alpha,25-dihydroxyvitamin D3, 1alpha,25-(OH)2D3), may act positively in concert with conventional therapies of colon cancer. SN - 1011-1344 UR - https://www.unboundmedicine.com/medline/citation/15708515/Solar_radiation_vitamin_D_and_survival_rate_of_colon_cancer_in_Norway_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1011-1344(04)00175-7 DB - PRIME DP - Unbound Medicine ER -