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Oxidative stress in Alzheimer's disease: implications for prevention and therapy.
Subcell Biochem. 2005; 38:65-78.SB

Abstract

Oxidative stress is a marker of neurodegeneration and has been recently shown to be also involved in the early stages of the pathogenesis of various neurodegenerative disorders. In general, all biomolecules of the cell can be oxidized and thereby damaged. Consequently, the concept of neuroprotection by antioxidants has been developed. In many cases the direct scavanging of free radicals have been used as a strategy to prevent oxidative stress damage and a variety of physiological and synthetic antioxidant molecules have been identified and synthesized including the female sex homone estrogen. In Alzheimer's Disease amyloid-beta protein on its way to brain deposition can also induce oxidative changes rendering nerve cells more vulnerable to additional insults. In addition, inflammatory mediators are attracted by amyloid deposits that can further speed up the generation of an oxidative micro-environment. Based on recent clinical data the use of a combination of various antioxidants might indeed be effective in preventing Alzheimer's Disease. Nevertheless, the exact molecular mechanisms and the real impact of oxidative stress on the development and progression of Alzheimer's Disease as well as of other neurodegenerative disorders still needs to be further investigated.

Authors+Show Affiliations

Institute for Physiological Chemistry & Pathobiochemistry, Faculty of Medicine, Johannes Gutenberg University, Mainz, D-55099 Mainz, Germany.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15709473

Citation

Behl, Christian. "Oxidative Stress in Alzheimer's Disease: Implications for Prevention and Therapy." Sub-cellular Biochemistry, vol. 38, 2005, pp. 65-78.
Behl C. Oxidative stress in Alzheimer's disease: implications for prevention and therapy. Subcell Biochem. 2005;38:65-78.
Behl, C. (2005). Oxidative stress in Alzheimer's disease: implications for prevention and therapy. Sub-cellular Biochemistry, 38, 65-78.
Behl C. Oxidative Stress in Alzheimer's Disease: Implications for Prevention and Therapy. Subcell Biochem. 2005;38:65-78. PubMed PMID: 15709473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress in Alzheimer's disease: implications for prevention and therapy. A1 - Behl,Christian, PY - 2005/2/16/pubmed PY - 2005/4/13/medline PY - 2005/2/16/entrez SP - 65 EP - 78 JF - Sub-cellular biochemistry JO - Subcell Biochem VL - 38 N2 - Oxidative stress is a marker of neurodegeneration and has been recently shown to be also involved in the early stages of the pathogenesis of various neurodegenerative disorders. In general, all biomolecules of the cell can be oxidized and thereby damaged. Consequently, the concept of neuroprotection by antioxidants has been developed. In many cases the direct scavanging of free radicals have been used as a strategy to prevent oxidative stress damage and a variety of physiological and synthetic antioxidant molecules have been identified and synthesized including the female sex homone estrogen. In Alzheimer's Disease amyloid-beta protein on its way to brain deposition can also induce oxidative changes rendering nerve cells more vulnerable to additional insults. In addition, inflammatory mediators are attracted by amyloid deposits that can further speed up the generation of an oxidative micro-environment. Based on recent clinical data the use of a combination of various antioxidants might indeed be effective in preventing Alzheimer's Disease. Nevertheless, the exact molecular mechanisms and the real impact of oxidative stress on the development and progression of Alzheimer's Disease as well as of other neurodegenerative disorders still needs to be further investigated. SN - 0306-0225 UR - https://www.unboundmedicine.com/medline/citation/15709473/Oxidative_stress_in_Alzheimer's_disease:_implications_for_prevention_and_therapy_ DB - PRIME DP - Unbound Medicine ER -
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