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Grown-up coeliac children: the effects of only a few years on a gluten-free diet in childhood.
Aliment Pharmacol Ther 2005; 21(4):421-9AP

Abstract

AIM

To evaluate clinical and psychological status of adults with childhood diagnosis of coeliac disease who were re-exposed to gluten after only a few years and now on a gluten-containing diet, compared with adults with recent diagnosis of coeliac disease, and adults who remained on gluten-free diet after childhood diagnosis.

METHODS

A total of 195 adults with a biopsy suggestive of coeliac disease in childhood, who either had adhered to a gluten-free diet for at least 1 year after diagnosis and now are either on gluten-free diet (n = 110) or on gluten-containing diet (n = 85), and adults with newly diagnosed coeliac disease (n = 165) underwent a medical check-up.

RESULTS

Body mass index and main laboratory indices were statistically different among groups (lowest in never on gluten-free diet, highest in gluten-free diet). The lowest average levels of bone mineral density were found among never on gluten-free diet patients. Prevalence of autoimmune disorders was increased in never on gluten-free diet when compared with the transient gluten-free diet and gluten-free diet groups. Histology revealed villous subatrophy in all patients of never on gluten-free diet group, in 39 of 110 patients of gluten-free diet and in 84 of 85 of transient gluten-free diet groups. Herpetiform dermatitis was found in three patients of gluten-free diet, three of transient gluten-free diet and three of never on gluten-free diet. Dental enamel defects were found in 15 patients of transient gluten-free diet, 43 of never on gluten-free diet and in zero of the gluten-free diet group. Pregnancy outcome was not significantly different between the two groups, but neonatal weight was lower and breast feeding was shorter in the never on gluten-free diet group. Sexual habits, alcohol intake and cigarette smoking were significantly different in the never on gluten-free diet group when compared with the other two groups.

CONCLUSION

Gluten withdrawal in childhood partly protects coeliac adults from clinical and behavioural effects of gluten sensitivity.

Authors+Show Affiliations

Gastrointestinal Unit, Federico II University of Napoli, Naples, Italy. ciacci@unina.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15709993

Citation

Ciacci, C, et al. "Grown-up Coeliac Children: the Effects of Only a Few Years On a Gluten-free Diet in Childhood." Alimentary Pharmacology & Therapeutics, vol. 21, no. 4, 2005, pp. 421-9.
Ciacci C, Iovino P, Amoruso D, et al. Grown-up coeliac children: the effects of only a few years on a gluten-free diet in childhood. Aliment Pharmacol Ther. 2005;21(4):421-9.
Ciacci, C., Iovino, P., Amoruso, D., Siniscalchi, M., Tortora, R., Di Gilio, A., ... Mazzacca, G. (2005). Grown-up coeliac children: the effects of only a few years on a gluten-free diet in childhood. Alimentary Pharmacology & Therapeutics, 21(4), pp. 421-9.
Ciacci C, et al. Grown-up Coeliac Children: the Effects of Only a Few Years On a Gluten-free Diet in Childhood. Aliment Pharmacol Ther. 2005 Feb 15;21(4):421-9. PubMed PMID: 15709993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Grown-up coeliac children: the effects of only a few years on a gluten-free diet in childhood. AU - Ciacci,C, AU - Iovino,P, AU - Amoruso,D, AU - Siniscalchi,M, AU - Tortora,R, AU - Di Gilio,A, AU - Fusco,M, AU - Mazzacca,G, PY - 2005/2/16/pubmed PY - 2005/5/25/medline PY - 2005/2/16/entrez SP - 421 EP - 9 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 21 IS - 4 N2 - AIM: To evaluate clinical and psychological status of adults with childhood diagnosis of coeliac disease who were re-exposed to gluten after only a few years and now on a gluten-containing diet, compared with adults with recent diagnosis of coeliac disease, and adults who remained on gluten-free diet after childhood diagnosis. METHODS: A total of 195 adults with a biopsy suggestive of coeliac disease in childhood, who either had adhered to a gluten-free diet for at least 1 year after diagnosis and now are either on gluten-free diet (n = 110) or on gluten-containing diet (n = 85), and adults with newly diagnosed coeliac disease (n = 165) underwent a medical check-up. RESULTS: Body mass index and main laboratory indices were statistically different among groups (lowest in never on gluten-free diet, highest in gluten-free diet). The lowest average levels of bone mineral density were found among never on gluten-free diet patients. Prevalence of autoimmune disorders was increased in never on gluten-free diet when compared with the transient gluten-free diet and gluten-free diet groups. Histology revealed villous subatrophy in all patients of never on gluten-free diet group, in 39 of 110 patients of gluten-free diet and in 84 of 85 of transient gluten-free diet groups. Herpetiform dermatitis was found in three patients of gluten-free diet, three of transient gluten-free diet and three of never on gluten-free diet. Dental enamel defects were found in 15 patients of transient gluten-free diet, 43 of never on gluten-free diet and in zero of the gluten-free diet group. Pregnancy outcome was not significantly different between the two groups, but neonatal weight was lower and breast feeding was shorter in the never on gluten-free diet group. Sexual habits, alcohol intake and cigarette smoking were significantly different in the never on gluten-free diet group when compared with the other two groups. CONCLUSION: Gluten withdrawal in childhood partly protects coeliac adults from clinical and behavioural effects of gluten sensitivity. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/15709993/Grown_up_coeliac_children:_the_effects_of_only_a_few_years_on_a_gluten_free_diet_in_childhood_ L2 - https://doi.org/10.1111/j.1365-2036.2005.02345.x DB - PRIME DP - Unbound Medicine ER -