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The polymorphism interleukin 8 -251 A/T influences the susceptibility of Helicobacter pylori related gastric diseases in the Japanese population.
Gut. 2005 Mar; 54(3):330-5.Gut

Abstract

BACKGROUND

Helicobacter pylori infection is associated with variable clinical outcomes, including gastroduodenal diseases, and genetic factors may be relevant in this process.

AIMS

We investigated the effects of an interleukin 8 (IL-8) gene polymorphism on the risk of gastroduodenal diseases, the degree of H pylori induced gastritis, and IL-8 gene transcription.

SUBJECTS

The study was performed in 244 healthy control subjects and 690 H pylori positive patients with non-cardia gastric cancer, gastric ulcer, duodenal ulcer, or gastritis.

METHODS

We identified the IL-8 -251 A/T polymorphism by direct sequence analysis, and measured the gastritis score and serum pepsinogen (PG). The transcriptional promoter activity of the IL-8 gene was assessed by luciferase assay.

RESULTS

IL-8 -251A was associated with a higher risk of gastric cancer and gastric ulcer. Patients carrying IL-8 -251A showed an increased risk of gastric cancer (odds ratios (OR) 2.01 (95% confidence interval (CI) 1.38-2.92)) and gastric ulcer (OR 2.07 (95% CI 1.37-3.12)). Compared with patients younger than 49 years, atrophy and metaplasia scores in the antrum were significantly higher and the PG I/II ratio significantly lower in -251A carriers than in T/T carriers. In the in vitro assay, IL-8 -251A showed enhanced promoter activity in response to IL-1beta or tumour necrosis factor alpha.

CONCLUSIONS

The IL-8 -251A allele may be associated with progression of gastric atrophy in patients with H pylori infection, and may increase the risk of gastric cancer and gastric ulcer in Japanese people.

Authors+Show Affiliations

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan. moyauchi@int3.med.tohoku.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15710978

Citation

Ohyauchi, M, et al. "The Polymorphism Interleukin 8 -251 A/T Influences the Susceptibility of Helicobacter Pylori Related Gastric Diseases in the Japanese Population." Gut, vol. 54, no. 3, 2005, pp. 330-5.
Ohyauchi M, Imatani A, Yonechi M, et al. The polymorphism interleukin 8 -251 A/T influences the susceptibility of Helicobacter pylori related gastric diseases in the Japanese population. Gut. 2005;54(3):330-5.
Ohyauchi, M., Imatani, A., Yonechi, M., Asano, N., Miura, A., Iijima, K., Koike, T., Sekine, H., Ohara, S., & Shimosegawa, T. (2005). The polymorphism interleukin 8 -251 A/T influences the susceptibility of Helicobacter pylori related gastric diseases in the Japanese population. Gut, 54(3), 330-5.
Ohyauchi M, et al. The Polymorphism Interleukin 8 -251 A/T Influences the Susceptibility of Helicobacter Pylori Related Gastric Diseases in the Japanese Population. Gut. 2005;54(3):330-5. PubMed PMID: 15710978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The polymorphism interleukin 8 -251 A/T influences the susceptibility of Helicobacter pylori related gastric diseases in the Japanese population. AU - Ohyauchi,M, AU - Imatani,A, AU - Yonechi,M, AU - Asano,N, AU - Miura,A, AU - Iijima,K, AU - Koike,T, AU - Sekine,H, AU - Ohara,S, AU - Shimosegawa,T, PY - 2005/2/16/pubmed PY - 2005/3/16/medline PY - 2005/2/16/entrez SP - 330 EP - 5 JF - Gut JO - Gut VL - 54 IS - 3 N2 - BACKGROUND: Helicobacter pylori infection is associated with variable clinical outcomes, including gastroduodenal diseases, and genetic factors may be relevant in this process. AIMS: We investigated the effects of an interleukin 8 (IL-8) gene polymorphism on the risk of gastroduodenal diseases, the degree of H pylori induced gastritis, and IL-8 gene transcription. SUBJECTS: The study was performed in 244 healthy control subjects and 690 H pylori positive patients with non-cardia gastric cancer, gastric ulcer, duodenal ulcer, or gastritis. METHODS: We identified the IL-8 -251 A/T polymorphism by direct sequence analysis, and measured the gastritis score and serum pepsinogen (PG). The transcriptional promoter activity of the IL-8 gene was assessed by luciferase assay. RESULTS: IL-8 -251A was associated with a higher risk of gastric cancer and gastric ulcer. Patients carrying IL-8 -251A showed an increased risk of gastric cancer (odds ratios (OR) 2.01 (95% confidence interval (CI) 1.38-2.92)) and gastric ulcer (OR 2.07 (95% CI 1.37-3.12)). Compared with patients younger than 49 years, atrophy and metaplasia scores in the antrum were significantly higher and the PG I/II ratio significantly lower in -251A carriers than in T/T carriers. In the in vitro assay, IL-8 -251A showed enhanced promoter activity in response to IL-1beta or tumour necrosis factor alpha. CONCLUSIONS: The IL-8 -251A allele may be associated with progression of gastric atrophy in patients with H pylori infection, and may increase the risk of gastric cancer and gastric ulcer in Japanese people. SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/15710978/The_polymorphism_interleukin_8__251_A/T_influences_the_susceptibility_of_Helicobacter_pylori_related_gastric_diseases_in_the_Japanese_population_ L2 - https://gut.bmj.com/lookup/pmidlookup?view=long&pmid=15710978 DB - PRIME DP - Unbound Medicine ER -