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Laparoscopic radical prostatectomy with the Heilbronn technique: oncological results in the first 500 patients.
J Urol. 2005 Mar; 173(3):761-4.JU

Abstract

PURPOSE

Laparoscopic radical prostatectomy has become an accepted alternative to open surgery. However, there is still a lack of data concerning the oncological outcome.

MATERIALS AND METHODS

From March 1999 to July 2004, 1,078 patients underwent laparoscopic radical prostatectomy at our institution. Oncological results in the first 500 patients with a minimal followup of 23 months were analyzed, focusing on positive margins, prostate specific antigen (PSA) failure, clinical progression and survival.

RESULTS

Median followup was 40 months (range 23 to 65). Of the patients 417 underwent pelvic lymph node dissection, which revealed positive nodes in 6 (1.2%). Positive margins were documented in 22 of 296 pT2 tumors (7.4%), 27 of 107 pT3a tumors (25.2%) and 29 of 69 pT3b tumors (42.0%). PSA recurrence was diagnosed in 55 patients (11.0%) at a mean of 20.8 months (range 6 to 36) that is stages pT2a, pT2b, pT3a and pT3b/4 in 3.2%, 6.5%, 15.9% and 23.9%, respectively. PSA progression-free rates were 83.0% at 3 years and 73.1% at 5 years. Two patients died of disease and 6 died of other causes (99.2% overall survival). The clinical progression rate was to 4.1% at 3 years and 9.8% at 5 years. No port site metastasis was observed.

CONCLUSIONS

At centers of expertise laparoscopic radical prostatectomy may provide an oncological outcome similar to that of the open procedure. However, it offers the advantages of minimally invasive surgery.

Authors+Show Affiliations

Department of Pathology, Klinikum Heilbronn, University of Heidelberg, Heidelberg, Germany. jens.rassweiler@slk-kliniken.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

15711264

Citation

Rassweiler, Jens, et al. "Laparoscopic Radical Prostatectomy With the Heilbronn Technique: Oncological Results in the First 500 Patients." The Journal of Urology, vol. 173, no. 3, 2005, pp. 761-4.
Rassweiler J, Schulze M, Teber D, et al. Laparoscopic radical prostatectomy with the Heilbronn technique: oncological results in the first 500 patients. J Urol. 2005;173(3):761-4.
Rassweiler, J., Schulze, M., Teber, D., Marrero, R., Seemann, O., Rumpelt, J., & Frede, T. (2005). Laparoscopic radical prostatectomy with the Heilbronn technique: oncological results in the first 500 patients. The Journal of Urology, 173(3), 761-4.
Rassweiler J, et al. Laparoscopic Radical Prostatectomy With the Heilbronn Technique: Oncological Results in the First 500 Patients. J Urol. 2005;173(3):761-4. PubMed PMID: 15711264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Laparoscopic radical prostatectomy with the Heilbronn technique: oncological results in the first 500 patients. AU - Rassweiler,Jens, AU - Schulze,Michael, AU - Teber,Dogu, AU - Marrero,Reinaldo, AU - Seemann,Othmar, AU - Rumpelt,Joachim, AU - Frede,Thomas, PY - 2005/2/16/pubmed PY - 2005/3/30/medline PY - 2005/2/16/entrez SP - 761 EP - 4 JF - The Journal of urology JO - J Urol VL - 173 IS - 3 N2 - PURPOSE: Laparoscopic radical prostatectomy has become an accepted alternative to open surgery. However, there is still a lack of data concerning the oncological outcome. MATERIALS AND METHODS: From March 1999 to July 2004, 1,078 patients underwent laparoscopic radical prostatectomy at our institution. Oncological results in the first 500 patients with a minimal followup of 23 months were analyzed, focusing on positive margins, prostate specific antigen (PSA) failure, clinical progression and survival. RESULTS: Median followup was 40 months (range 23 to 65). Of the patients 417 underwent pelvic lymph node dissection, which revealed positive nodes in 6 (1.2%). Positive margins were documented in 22 of 296 pT2 tumors (7.4%), 27 of 107 pT3a tumors (25.2%) and 29 of 69 pT3b tumors (42.0%). PSA recurrence was diagnosed in 55 patients (11.0%) at a mean of 20.8 months (range 6 to 36) that is stages pT2a, pT2b, pT3a and pT3b/4 in 3.2%, 6.5%, 15.9% and 23.9%, respectively. PSA progression-free rates were 83.0% at 3 years and 73.1% at 5 years. Two patients died of disease and 6 died of other causes (99.2% overall survival). The clinical progression rate was to 4.1% at 3 years and 9.8% at 5 years. No port site metastasis was observed. CONCLUSIONS: At centers of expertise laparoscopic radical prostatectomy may provide an oncological outcome similar to that of the open procedure. However, it offers the advantages of minimally invasive surgery. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/15711264/Laparoscopic_radical_prostatectomy_with_the_Heilbronn_technique:_oncological_results_in_the_first_500_patients_ L2 - https://www.jurology.com/doi/10.1097/01.ju.0000153486.94741.e5?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -