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The role of vitamin E in the prevention of coronary events and stroke. Meta-analysis of randomized controlled trials.
Saudi Med J 2004; 25(12):1808-14SM

Abstract

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the world. Vitamin E as an anti-oxidant vitamin, was suggested to have a role in the prevention of CVD. We did a meta-analysis, using the Cochrane Group Methodology, of all available randomized controlled trials (RCTs) to evaluate the role of vitamin E in the prevention of CVD. Nine studies met inclusion criteria, including 80,645 participants. Vitamin E supplementation was not associated with a reduction in total mortality or total CVD mortality, but it was associated with a small statistically significant reduction in non-fatal myocardial infarction in patients with pre-existing coronary artery disease. Prophylactic use of vitamin E in doses ranging between 50-800 IU was not associated with any increase in the incidence of serious side effects.

Authors+Show Affiliations

Department of Family Medicine and Polyclinic, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia. alkhenizan@hotmail.comNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

15711645

Citation

Alkhenizan, Abdullah H., and Mohammed A. Al-Omran. "The Role of Vitamin E in the Prevention of Coronary Events and Stroke. Meta-analysis of Randomized Controlled Trials." Saudi Medical Journal, vol. 25, no. 12, 2004, pp. 1808-14.
Alkhenizan AH, Al-Omran MA. The role of vitamin E in the prevention of coronary events and stroke. Meta-analysis of randomized controlled trials. Saudi Med J. 2004;25(12):1808-14.
Alkhenizan, A. H., & Al-Omran, M. A. (2004). The role of vitamin E in the prevention of coronary events and stroke. Meta-analysis of randomized controlled trials. Saudi Medical Journal, 25(12), pp. 1808-14.
Alkhenizan AH, Al-Omran MA. The Role of Vitamin E in the Prevention of Coronary Events and Stroke. Meta-analysis of Randomized Controlled Trials. Saudi Med J. 2004;25(12):1808-14. PubMed PMID: 15711645.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of vitamin E in the prevention of coronary events and stroke. Meta-analysis of randomized controlled trials. AU - Alkhenizan,Abdullah H, AU - Al-Omran,Mohammed A, PY - 2005/2/16/pubmed PY - 2005/4/9/medline PY - 2005/2/16/entrez SP - 1808 EP - 14 JF - Saudi medical journal JO - Saudi Med J VL - 25 IS - 12 N2 - Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the world. Vitamin E as an anti-oxidant vitamin, was suggested to have a role in the prevention of CVD. We did a meta-analysis, using the Cochrane Group Methodology, of all available randomized controlled trials (RCTs) to evaluate the role of vitamin E in the prevention of CVD. Nine studies met inclusion criteria, including 80,645 participants. Vitamin E supplementation was not associated with a reduction in total mortality or total CVD mortality, but it was associated with a small statistically significant reduction in non-fatal myocardial infarction in patients with pre-existing coronary artery disease. Prophylactic use of vitamin E in doses ranging between 50-800 IU was not associated with any increase in the incidence of serious side effects. SN - 0379-5284 UR - https://www.unboundmedicine.com/medline/citation/15711645/The_role_of_vitamin_E_in_the_prevention_of_coronary_events_and_stroke__Meta_analysis_of_randomized_controlled_trials_ L2 - https://medlineplus.gov/vitamine.html DB - PRIME DP - Unbound Medicine ER -