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Combined use of amisulpride and clozapine for patients with treatment-resistant schizophrenia.
Australas Psychiatry. 2004 Mar; 12(1):74-6.AP

Abstract

OBJECTIVE

To report on a trial of adding amisulpride to clozapine.

METHODS

Description of six cases.

RESULTS

Six patients who had been on clozapine were commenced on amisulpride. All patients had had unwanted effects with clozapine, particularly sedation, hypersalivation, or weight gain. Five patients reported a high level of satisfaction with the regimen, having a reduction in the level of sedation and improvement in levels of motivation and energy, without recurrence of positive symptoms.

CONCLUSION

The combined use of amisulpride and clozapine would appear to be an appropriate and beneficial treatment.

Links

Publisher Full Text
journals.sagepub.com
onlinelibrary.wiley.com
Aggregator Full Text

Authors+Show Affiliations

Cook B
Bundaberg Integrated Mental Health Service, Bundaberg, Queensland 4670, Australia.
Hoogenboom G
No affiliation info available

MeSH

AdultAmisulprideAntipsychotic AgentsClozapineDose-Response Relationship, DrugDrug Administration ScheduleDrug ResistanceDrug Therapy, CombinationFemaleHumansMaleMiddle AgedPatient SatisfactionSchizophreniaSchizophrenic PsychologySulpirideTreatment Outcome

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15715745

Citation

Cook, Brian, and Gerry Hoogenboom. "Combined Use of Amisulpride and Clozapine for Patients With Treatment-resistant Schizophrenia." Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists, vol. 12, no. 1, 2004, pp. 74-6.
Cook B, Hoogenboom G. Combined use of amisulpride and clozapine for patients with treatment-resistant schizophrenia. Australas Psychiatry. 2004;12(1):74-6.
Cook, B., & Hoogenboom, G. (2004). Combined use of amisulpride and clozapine for patients with treatment-resistant schizophrenia. Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists, 12(1), 74-6.
Cook B, Hoogenboom G. Combined Use of Amisulpride and Clozapine for Patients With Treatment-resistant Schizophrenia. Australas Psychiatry. 2004;12(1):74-6. PubMed PMID: 15715745.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined use of amisulpride and clozapine for patients with treatment-resistant schizophrenia. AU - Cook,Brian, AU - Hoogenboom,Gerry, PY - 2005/2/18/pubmed PY - 2005/4/12/medline PY - 2005/2/18/entrez SP - 74 EP - 6 JF - Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists JO - Australas Psychiatry VL - 12 IS - 1 N2 - OBJECTIVE: To report on a trial of adding amisulpride to clozapine. METHODS: Description of six cases. RESULTS: Six patients who had been on clozapine were commenced on amisulpride. All patients had had unwanted effects with clozapine, particularly sedation, hypersalivation, or weight gain. Five patients reported a high level of satisfaction with the regimen, having a reduction in the level of sedation and improvement in levels of motivation and energy, without recurrence of positive symptoms. CONCLUSION: The combined use of amisulpride and clozapine would appear to be an appropriate and beneficial treatment. SN - 1039-8562 UR - https://www.unboundmedicine.com/medline/citation/15715745/Combined_use_of_amisulpride_and_clozapine_for_patients_with_treatment_resistant_schizophrenia_ L2 - https://journals.sagepub.com/doi/10.1046/j.1039-8562.2003.02064.x?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -