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QT dispersion in type 2 diabetic patients with altered diurnal blood pressure rhythm.
Diabetes Obes Metab. 2005 Mar; 7(2):136-43.DO

Abstract

BACKGROUND

QT dispersion (QTd) is a good prognostic marker in type 2 diabetic patients without previous cardiovascular disease. Diabetic patients with an attenuated decline in nocturnal blood pressure (non-dippers) have been shown to have increased risk of diabetic complications, vascular events and mortality.

AIM

The aim of this study was to evaluate the relationship between diurnal blood pressure rhythm, QTd and microvascular complications in type 2 diabetic patients.

METHODS

Cardiovascular autonomic function tests, 24-h ambulatory blood pressure monitoring and urinary albumin excretion measurements were performed in healthy controls (n = 25), normoalbuminuric (n = 34) and microalbuminuric (n = 23) type 2 diabetic patients. QTd was assessed manually from 12-lead surface electrocardiograms.

RESULTS

Compared with the controls, both normoalbuminuric and microalbuminuric diabetic patients had increased QTd (59.11 +/- 15.86; 60.27 +/- 17.95 vs. 40.48 +/- 10.92, p < 0.001 and p < 0.001, respectively). Similarly, diabetic patients had increased QTd regardless of the presence of autonomic neuropathy. On the other hand, non-dipper diabetic patients had increased QTd compared with the controls and dipper diabetic patients (69.73 +/- 14.50 vs. 40.48 +/- 10.92; 47.84 +/- 9.62 ms, p < 0.001). There was a negative correlation between QTd and diurnal diastolic blood pressure change (r = -0.48, p < 0.0005).

CONCLUSION

Patients with type 2 diabetes mellitus were found to have increased QT dispersion irrespective of the presence of diabetic autonomic neuropathy. However, QT dispersion in dipper diabetic patients was similar to the controls. This finding might point out that attenuated decline of nocturnal blood pressure could be a more sensitive marker for autonomic neuropathy.

Authors+Show Affiliations

Marmara University Division of Endocrinology and Metabolism, Istanbul, Turkey. odeyneli@marmara.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15715886

Citation

Deyneli, O, et al. "QT Dispersion in Type 2 Diabetic Patients With Altered Diurnal Blood Pressure Rhythm." Diabetes, Obesity & Metabolism, vol. 7, no. 2, 2005, pp. 136-43.
Deyneli O, Ersöz HO, Yavuz D, et al. QT dispersion in type 2 diabetic patients with altered diurnal blood pressure rhythm. Diabetes Obes Metab. 2005;7(2):136-43.
Deyneli, O., Ersöz, H. O., Yavuz, D., Fak, A. S., & Akalin, S. (2005). QT dispersion in type 2 diabetic patients with altered diurnal blood pressure rhythm. Diabetes, Obesity & Metabolism, 7(2), 136-43.
Deyneli O, et al. QT Dispersion in Type 2 Diabetic Patients With Altered Diurnal Blood Pressure Rhythm. Diabetes Obes Metab. 2005;7(2):136-43. PubMed PMID: 15715886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - QT dispersion in type 2 diabetic patients with altered diurnal blood pressure rhythm. AU - Deyneli,O, AU - Ersöz,H O, AU - Yavuz,D, AU - Fak,A S, AU - Akalin,S, PY - 2005/2/18/pubmed PY - 2005/6/10/medline PY - 2005/2/18/entrez SP - 136 EP - 43 JF - Diabetes, obesity & metabolism JO - Diabetes Obes Metab VL - 7 IS - 2 N2 - BACKGROUND: QT dispersion (QTd) is a good prognostic marker in type 2 diabetic patients without previous cardiovascular disease. Diabetic patients with an attenuated decline in nocturnal blood pressure (non-dippers) have been shown to have increased risk of diabetic complications, vascular events and mortality. AIM: The aim of this study was to evaluate the relationship between diurnal blood pressure rhythm, QTd and microvascular complications in type 2 diabetic patients. METHODS: Cardiovascular autonomic function tests, 24-h ambulatory blood pressure monitoring and urinary albumin excretion measurements were performed in healthy controls (n = 25), normoalbuminuric (n = 34) and microalbuminuric (n = 23) type 2 diabetic patients. QTd was assessed manually from 12-lead surface electrocardiograms. RESULTS: Compared with the controls, both normoalbuminuric and microalbuminuric diabetic patients had increased QTd (59.11 +/- 15.86; 60.27 +/- 17.95 vs. 40.48 +/- 10.92, p < 0.001 and p < 0.001, respectively). Similarly, diabetic patients had increased QTd regardless of the presence of autonomic neuropathy. On the other hand, non-dipper diabetic patients had increased QTd compared with the controls and dipper diabetic patients (69.73 +/- 14.50 vs. 40.48 +/- 10.92; 47.84 +/- 9.62 ms, p < 0.001). There was a negative correlation between QTd and diurnal diastolic blood pressure change (r = -0.48, p < 0.0005). CONCLUSION: Patients with type 2 diabetes mellitus were found to have increased QT dispersion irrespective of the presence of diabetic autonomic neuropathy. However, QT dispersion in dipper diabetic patients was similar to the controls. This finding might point out that attenuated decline of nocturnal blood pressure could be a more sensitive marker for autonomic neuropathy. SN - 1462-8902 UR - https://www.unboundmedicine.com/medline/citation/15715886/QT_dispersion_in_type_2_diabetic_patients_with_altered_diurnal_blood_pressure_rhythm_ L2 - https://doi.org/10.1111/j.1463-1326.2004.00378.x DB - PRIME DP - Unbound Medicine ER -