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Efficacy of albendazole-GM6001 co-therapy against Angiostrongylus cantonensis-induced meningitis in BALB/c mice.
Acta Trop. 2005 Mar; 93(3):267-73.AT

Abstract

Angiostrongylus cantonensis causes a form of parasitic meningitis in humans. Albendazole kills the nematode larvae staying in the brain. However, the dead larvae are capable of evoking a severe inflammatory response resulting in the brain damage. Matrix metalloproteinase 9 (MMP-9) is associated with the development of meningitis and with the immune inflammatory reaction. Presently, we studied the combination effects of albendazole and GM6001 (a MMP-9 inhibitor) against angiostrongyliasis in BALB/c mice. Co-administration of drugs produced marked effects; to kill the infecting larvae and to block MMP-9 activity. The combination treatment reduced MMP-9 activity by 89.2% in cerebrospinal fluid. The numbers of inflammatory cells increased significantly upon establishment of infection, but subsided upon co-treatment. Significantly fewer larvae were recovered from treated mice than from untreated, infected mice. The present results strongly suggest that co-therapy with albendazole and GM6001 may be an useful approach for the treatment of human angiostrongyliasis.

Authors+Show Affiliations

Department of Parasitology, Chung Shan Medical University, 110 Section 1, Chien-Kuo North Road, Taichung 402, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15716044

Citation

Lai, S C., et al. "Efficacy of albendazole-GM6001 Co-therapy Against Angiostrongylus Cantonensis-induced Meningitis in BALB/c Mice." Acta Tropica, vol. 93, no. 3, 2005, pp. 267-73.
Lai SC, Jiang ST, Chen KM, et al. Efficacy of albendazole-GM6001 co-therapy against Angiostrongylus cantonensis-induced meningitis in BALB/c mice. Acta Trop. 2005;93(3):267-73.
Lai, S. C., Jiang, S. T., Chen, K. M., Hsu, J. D., Shyu, L. Y., & Lee, H. H. (2005). Efficacy of albendazole-GM6001 co-therapy against Angiostrongylus cantonensis-induced meningitis in BALB/c mice. Acta Tropica, 93(3), 267-73.
Lai SC, et al. Efficacy of albendazole-GM6001 Co-therapy Against Angiostrongylus Cantonensis-induced Meningitis in BALB/c Mice. Acta Trop. 2005;93(3):267-73. PubMed PMID: 15716044.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of albendazole-GM6001 co-therapy against Angiostrongylus cantonensis-induced meningitis in BALB/c mice. AU - Lai,S C, AU - Jiang,S T, AU - Chen,K M, AU - Hsu,J D, AU - Shyu,L Y, AU - Lee,H H, PY - 2004/05/18/received PY - 2004/12/08/revised PY - 2004/12/14/accepted PY - 2005/2/18/pubmed PY - 2005/5/4/medline PY - 2005/2/18/entrez SP - 267 EP - 73 JF - Acta tropica JO - Acta Trop VL - 93 IS - 3 N2 - Angiostrongylus cantonensis causes a form of parasitic meningitis in humans. Albendazole kills the nematode larvae staying in the brain. However, the dead larvae are capable of evoking a severe inflammatory response resulting in the brain damage. Matrix metalloproteinase 9 (MMP-9) is associated with the development of meningitis and with the immune inflammatory reaction. Presently, we studied the combination effects of albendazole and GM6001 (a MMP-9 inhibitor) against angiostrongyliasis in BALB/c mice. Co-administration of drugs produced marked effects; to kill the infecting larvae and to block MMP-9 activity. The combination treatment reduced MMP-9 activity by 89.2% in cerebrospinal fluid. The numbers of inflammatory cells increased significantly upon establishment of infection, but subsided upon co-treatment. Significantly fewer larvae were recovered from treated mice than from untreated, infected mice. The present results strongly suggest that co-therapy with albendazole and GM6001 may be an useful approach for the treatment of human angiostrongyliasis. SN - 0001-706X UR - https://www.unboundmedicine.com/medline/citation/15716044/Efficacy_of_albendazole_GM6001_co_therapy_against_Angiostrongylus_cantonensis_induced_meningitis_in_BALB/c_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0001-706X(05)00018-5 DB - PRIME DP - Unbound Medicine ER -