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Incidence of disease after vasectomy: a record linkage retrospective cohort study.
BMJ. 1992 Mar 21; 304(6829):743-6.BMJ

Abstract

OBJECTIVE

To determine whether vasectomy is associated with an increased risk of several diseases, and in particular testicular cancer, after operation.

DESIGN

Retrospective cohort study using linked medical record abstracts.

SETTING

Six health districts in Oxford region.

SUBJECTS

13,246 men aged 25-49 years who had undergone vasectomy between 1970 and 1986, and 22,196 comparison subjects who had been admitted during the same period for one of three specified elective operations, appendicitis, or injuries.

MAIN OUTCOME MEASURES

Hospital admission and death after vasectomy or comparison event.

RESULTS

The mean durations of follow up were 6.6 years for men with a vasectomy and 7.5 years for men with a comparison condition. The relative risk of cancer of the testis in the vasectomy cohort (4 cases) compared with that in the other cohorts (17 cases) was 0.46 (95% confidence interval 0.1 to 1.4), that of cancer of the prostate (1 v 5 cases) 0.44 (0.1 to 4.0), and that of myocardial infarction (97 v 226 cases) 1.00 (0.8 to 1.3). There was no evidence of an increase associated with vasectomy in the incidence of a range of other diseases.

CONCLUSIONS

Vasectomy was not associated with an increased risk of testicular cancer or the other diseases studied. With respect to prostatic cancer, while we found no cause for concern, longer periods of observation on large numbers of men are required.

Authors+Show Affiliations

Unit of Clinical Epidemiology, University of Oxford.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

1571679

Citation

Nienhuis, H, et al. "Incidence of Disease After Vasectomy: a Record Linkage Retrospective Cohort Study." BMJ (Clinical Research Ed.), vol. 304, no. 6829, 1992, pp. 743-6.
Nienhuis H, Goldacre M, Seagroatt V, et al. Incidence of disease after vasectomy: a record linkage retrospective cohort study. BMJ. 1992;304(6829):743-6.
Nienhuis, H., Goldacre, M., Seagroatt, V., Gill, L., & Vessey, M. (1992). Incidence of disease after vasectomy: a record linkage retrospective cohort study. BMJ (Clinical Research Ed.), 304(6829), 743-6.
Nienhuis H, et al. Incidence of Disease After Vasectomy: a Record Linkage Retrospective Cohort Study. BMJ. 1992 Mar 21;304(6829):743-6. PubMed PMID: 1571679.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence of disease after vasectomy: a record linkage retrospective cohort study. AU - Nienhuis,H, AU - Goldacre,M, AU - Seagroatt,V, AU - Gill,L, AU - Vessey,M, PY - 1992/3/21/pubmed PY - 1992/3/21/medline PY - 1992/3/21/entrez KW - Age Distribution KW - Age Factors KW - Biology KW - Cancer KW - Cohort Analysis KW - Control Groups KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Europe KW - Family Planning KW - Genitalia KW - Genitalia, Male KW - Incidence KW - Information KW - Information Processing KW - Male Sterilization KW - Measurement KW - Neoplasms KW - Northern Europe KW - Physiology KW - Population KW - Population Characteristics KW - Prostate KW - Records KW - Research Methodology KW - Retrospective Studies KW - Risk Factors KW - Sterilization, Sexual KW - Studies KW - Testis KW - United Kingdom KW - Urogenital System KW - Vasectomy--side effects SP - 743 EP - 6 JF - BMJ (Clinical research ed.) JO - BMJ VL - 304 IS - 6829 N2 - OBJECTIVE: To determine whether vasectomy is associated with an increased risk of several diseases, and in particular testicular cancer, after operation. DESIGN: Retrospective cohort study using linked medical record abstracts. SETTING: Six health districts in Oxford region. SUBJECTS: 13,246 men aged 25-49 years who had undergone vasectomy between 1970 and 1986, and 22,196 comparison subjects who had been admitted during the same period for one of three specified elective operations, appendicitis, or injuries. MAIN OUTCOME MEASURES: Hospital admission and death after vasectomy or comparison event. RESULTS: The mean durations of follow up were 6.6 years for men with a vasectomy and 7.5 years for men with a comparison condition. The relative risk of cancer of the testis in the vasectomy cohort (4 cases) compared with that in the other cohorts (17 cases) was 0.46 (95% confidence interval 0.1 to 1.4), that of cancer of the prostate (1 v 5 cases) 0.44 (0.1 to 4.0), and that of myocardial infarction (97 v 226 cases) 1.00 (0.8 to 1.3). There was no evidence of an increase associated with vasectomy in the incidence of a range of other diseases. CONCLUSIONS: Vasectomy was not associated with an increased risk of testicular cancer or the other diseases studied. With respect to prostatic cancer, while we found no cause for concern, longer periods of observation on large numbers of men are required. SN - 0959-8138 UR - https://www.unboundmedicine.com/medline/citation/1571679/Incidence_of_disease_after_vasectomy:_a_record_linkage_retrospective_cohort_study_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/1571679/ DB - PRIME DP - Unbound Medicine ER -