TY - JOUR T1 - Analysis of tumor necrosis factor-alpha, interleukin-6, interleukin-1beta, soluble tumor necrosis factor receptors I and II, interleukin-6 soluble receptor, interleukin-1 soluble receptor type II, interleukin-1 receptor antagonist, and protein in the synovial fluid of patients with temporomandibular joint disorders. AU - Kaneyama,Keiseki, AU - Segami,Natsuki, AU - Sun,Wei, AU - Sato,Jun, AU - Fujimura,Kazuma, PY - 2005/2/18/pubmed PY - 2005/4/23/medline PY - 2005/2/18/entrez SP - 276 EP - 84 JF - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod VL - 99 IS - 3 N2 - OBJECTIVE: To measure the levels of various cytokines, cytokine receptors, and cytokine antagonists in the synovial fluid of patients with temporomandibular disorders (TMD) and to determine the correlations among these expression levels. STUDY DESIGN: Synovial fluid was obtained from 55 patients with TMD and from 5 asymptomatic healthy volunteers as controls. The concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-1beta, soluble tumor necrosis factor receptors I and II (sTNFR-I and sTNFR-II), IL-6 soluble receptor (IL-6sR), IL-1 soluble receptor type II, and IL-1 receptor antagonist were determined by enzyme-linked immunosorbent assay. RESULTS: The concentrations of TNF-alpha, IL-6, IL-1beta, sTNFR-I, and sTNFR-II were significantly higher in the synovial fluid of patients than in controls (P < .05). TNF-alpha level was positively correlated with those of IL-6, sTNFR-I, and sTNFR-II. In particular, there was a highly significant positive correlation between sTNFR-I and sTNFR-II. CONCLUSION: TNF and sTNFRs in the synovial fluid of patients with TMD may be important in the pathogenesis of these disorders. SN - 1079-2104 UR - https://www.unboundmedicine.com/medline/citation/15716832/Analysis_of_tumor_necrosis_factor_alpha_interleukin_6_interleukin_1beta_soluble_tumor_necrosis_factor_receptors_I_and_II_interleukin_6_soluble_receptor_interleukin_1_soluble_receptor_type_II_interleukin_1_receptor_antagonist_and_protein_in_the_synovial_fluid_of_patients_with_temporomandibular_joint_disorders_ DB - PRIME DP - Unbound Medicine ER -