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The J-shape effect of alcohol intake on the risk of developing acute coronary syndromes in diabetic subjects: the CARDIO2000 II Study.
Diabet Med. 2005 Mar; 22(3):243-8.DM

Abstract

AIMS

To identify the threshold of alcohol consumption above which the balance of risk and benefit becomes adverse in diabetic subjects.

METHODS

We studied demographic, lifestyle, dietary and clinical information in 216 hospitalized diabetic patients (171 men, 63 +/- 9 years old, 45 women, 67 +/- 5 years old) with a first event of an acute coronary syndrome (ACS) and 196 frequency matched (age-sex) diabetic controls, without any clinical evidence of coronary heart disease. Alcohol consumption was quantified and a measure for the comparisons was predetermined to be a wine glass (100 ml of wine, 12 g of ethanol) and its alcohol equivalents.

RESULTS

Alcohol consumption was associated with an age-adjusted J-shape relationship with total cholesterol, blood pressure and smoking (all P < 0.001). A J-shape association was also found between alcohol intake and the risk of ACS (OR = 2.54-2.43 x (alcohol intake) + 0.80 x (alcohol intake)2, R2 = 0.96, P < 0.001), adjusted for several risk factors and interactions between alcohol intake and smoking status, job and familial stress, and low income. In particular, low alcohol consumption (< 12 g/day) was associated with a 47% (OR = 0.53, 95% CI 0.28-0.97) reduction of the prevalence of ACS, while a higher intake (12-24 and > 24 g/day) increased the prevalence by 2.7-fold (OR = 2.72, 95% CI 1.39-5.38) and 5.4-fold (OR = 5.44, 95% CI 1.21-24.55), respectively.

CONCLUSIONS

Alcohol intake is a significant predictor of coronary events. Low-to-moderate intake seems to be associated with a reduction in the prevalence of ACS in diabetes, whereas higher consumption is associated with an increase in lipids and blood pressure levels, and also the risk of developing ACS.

Authors+Show Affiliations

First Cardiology Department, School of Medicine, University of Athens, Athens, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15717869

Citation

Pitsavos, C, et al. "The J-shape Effect of Alcohol Intake On the Risk of Developing Acute Coronary Syndromes in Diabetic Subjects: the CARDIO2000 II Study." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 22, no. 3, 2005, pp. 243-8.
Pitsavos C, Makrilakis K, Panagiotakos DB, et al. The J-shape effect of alcohol intake on the risk of developing acute coronary syndromes in diabetic subjects: the CARDIO2000 II Study. Diabet Med. 2005;22(3):243-8.
Pitsavos, C., Makrilakis, K., Panagiotakos, D. B., Chrysohoou, C., Ioannidis, I., Dimosthenopoulos, C., Stefanadis, C., & Katsilambros, N. (2005). The J-shape effect of alcohol intake on the risk of developing acute coronary syndromes in diabetic subjects: the CARDIO2000 II Study. Diabetic Medicine : a Journal of the British Diabetic Association, 22(3), 243-8.
Pitsavos C, et al. The J-shape Effect of Alcohol Intake On the Risk of Developing Acute Coronary Syndromes in Diabetic Subjects: the CARDIO2000 II Study. Diabet Med. 2005;22(3):243-8. PubMed PMID: 15717869.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The J-shape effect of alcohol intake on the risk of developing acute coronary syndromes in diabetic subjects: the CARDIO2000 II Study. AU - Pitsavos,C, AU - Makrilakis,K, AU - Panagiotakos,D B, AU - Chrysohoou,C, AU - Ioannidis,I, AU - Dimosthenopoulos,C, AU - Stefanadis,C, AU - Katsilambros,N, PY - 2005/2/19/pubmed PY - 2005/5/26/medline PY - 2005/2/19/entrez SP - 243 EP - 8 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 22 IS - 3 N2 - AIMS: To identify the threshold of alcohol consumption above which the balance of risk and benefit becomes adverse in diabetic subjects. METHODS: We studied demographic, lifestyle, dietary and clinical information in 216 hospitalized diabetic patients (171 men, 63 +/- 9 years old, 45 women, 67 +/- 5 years old) with a first event of an acute coronary syndrome (ACS) and 196 frequency matched (age-sex) diabetic controls, without any clinical evidence of coronary heart disease. Alcohol consumption was quantified and a measure for the comparisons was predetermined to be a wine glass (100 ml of wine, 12 g of ethanol) and its alcohol equivalents. RESULTS: Alcohol consumption was associated with an age-adjusted J-shape relationship with total cholesterol, blood pressure and smoking (all P < 0.001). A J-shape association was also found between alcohol intake and the risk of ACS (OR = 2.54-2.43 x (alcohol intake) + 0.80 x (alcohol intake)2, R2 = 0.96, P < 0.001), adjusted for several risk factors and interactions between alcohol intake and smoking status, job and familial stress, and low income. In particular, low alcohol consumption (< 12 g/day) was associated with a 47% (OR = 0.53, 95% CI 0.28-0.97) reduction of the prevalence of ACS, while a higher intake (12-24 and > 24 g/day) increased the prevalence by 2.7-fold (OR = 2.72, 95% CI 1.39-5.38) and 5.4-fold (OR = 5.44, 95% CI 1.21-24.55), respectively. CONCLUSIONS: Alcohol intake is a significant predictor of coronary events. Low-to-moderate intake seems to be associated with a reduction in the prevalence of ACS in diabetes, whereas higher consumption is associated with an increase in lipids and blood pressure levels, and also the risk of developing ACS. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/15717869/The_J_shape_effect_of_alcohol_intake_on_the_risk_of_developing_acute_coronary_syndromes_in_diabetic_subjects:_the_CARDIO2000_II_Study_ L2 - https://doi.org/10.1111/j.1464-5491.2004.01384.x DB - PRIME DP - Unbound Medicine ER -