Tags

Type your tag names separated by a space and hit enter

Plasma leptin concentration in patients with Type 2 diabetes: relationship to cardiovascular disease risk factors and insulin resistance.
Diabet Med. 2005 Mar; 22(3):278-85.DM

Abstract

AIMS

The aim of this study was to evaluate the relationship of obesity, leptin, insulin resistance and C-reactive protein (CRP) with coronary heart disease (CHD) risk factors in patients with Type 2 diabetes mellitus (DM) with CHD compared with those with Type 2 DM without CHD.

METHODS

Leptin, CRP (high sensitivity assay), fasting plasma insulin, glucose, HbA(1c) and full lipid profile were determined in 58 Type 2 diabetic patients with CHD and 87 Type 2 DM patients without CHD.

RESULTS

were compared between those with and without CHD. Univariate correlation as well as logistic regression analyses were used to relate these markers with traditional CHD risk factors.

RESULTS

Leptin showed significant correlations with BMI (r = 0.59; P < or = 0.0001), waist circumference (r = 0.45; P < 0.0001), CRP (r = 0.36; P < 0.0001), and fasting insulin (r = 0.53; P < 0.0001) as well as with systolic (r = 0.23; P = 0.007) and diastolic (r = 0.23; P = 0.007) blood pressure. However, when those with and without CHD were compared only age (P < 0.0001), duration of diabetes (P < 0.001) and degree of microalbuminuria (P = 0.02) were significantly higher in patients with CHD. Leptin (P = 0.49), CRP (P = 0.19) and lipid parameters were not significantly different between the two groups.

CONCLUSION

Our study confirms a relationship between leptin and CRP with CHD risk factors. The lack of significant difference when patients with and without CHD are compared may be due to the potential confounding effects of treatment with aspirin and statins.

Authors+Show Affiliations

Department of Medicine, Faculty of Medicine, Kuwait University, Kuwait. nabdella12@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15717875

Citation

Abdella, N A., et al. "Plasma Leptin Concentration in Patients With Type 2 Diabetes: Relationship to Cardiovascular Disease Risk Factors and Insulin Resistance." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 22, no. 3, 2005, pp. 278-85.
Abdella NA, Mojiminiyi OA, Moussa MA, et al. Plasma leptin concentration in patients with Type 2 diabetes: relationship to cardiovascular disease risk factors and insulin resistance. Diabet Med. 2005;22(3):278-85.
Abdella, N. A., Mojiminiyi, O. A., Moussa, M. A., Zaki, M., Al Mohammedi, H., Al Ozairi, E. S., & Al Jebely, S. (2005). Plasma leptin concentration in patients with Type 2 diabetes: relationship to cardiovascular disease risk factors and insulin resistance. Diabetic Medicine : a Journal of the British Diabetic Association, 22(3), 278-85.
Abdella NA, et al. Plasma Leptin Concentration in Patients With Type 2 Diabetes: Relationship to Cardiovascular Disease Risk Factors and Insulin Resistance. Diabet Med. 2005;22(3):278-85. PubMed PMID: 15717875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma leptin concentration in patients with Type 2 diabetes: relationship to cardiovascular disease risk factors and insulin resistance. AU - Abdella,N A, AU - Mojiminiyi,O A, AU - Moussa,M A, AU - Zaki,M, AU - Al Mohammedi,H, AU - Al Ozairi,E S S, AU - Al Jebely,S, PY - 2005/2/19/pubmed PY - 2005/5/26/medline PY - 2005/2/19/entrez SP - 278 EP - 85 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 22 IS - 3 N2 - AIMS: The aim of this study was to evaluate the relationship of obesity, leptin, insulin resistance and C-reactive protein (CRP) with coronary heart disease (CHD) risk factors in patients with Type 2 diabetes mellitus (DM) with CHD compared with those with Type 2 DM without CHD. METHODS: Leptin, CRP (high sensitivity assay), fasting plasma insulin, glucose, HbA(1c) and full lipid profile were determined in 58 Type 2 diabetic patients with CHD and 87 Type 2 DM patients without CHD. RESULTS: were compared between those with and without CHD. Univariate correlation as well as logistic regression analyses were used to relate these markers with traditional CHD risk factors. RESULTS: Leptin showed significant correlations with BMI (r = 0.59; P < or = 0.0001), waist circumference (r = 0.45; P < 0.0001), CRP (r = 0.36; P < 0.0001), and fasting insulin (r = 0.53; P < 0.0001) as well as with systolic (r = 0.23; P = 0.007) and diastolic (r = 0.23; P = 0.007) blood pressure. However, when those with and without CHD were compared only age (P < 0.0001), duration of diabetes (P < 0.001) and degree of microalbuminuria (P = 0.02) were significantly higher in patients with CHD. Leptin (P = 0.49), CRP (P = 0.19) and lipid parameters were not significantly different between the two groups. CONCLUSION: Our study confirms a relationship between leptin and CRP with CHD risk factors. The lack of significant difference when patients with and without CHD are compared may be due to the potential confounding effects of treatment with aspirin and statins. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/15717875/Plasma_leptin_concentration_in_patients_with_Type_2_diabetes:_relationship_to_cardiovascular_disease_risk_factors_and_insulin_resistance_ L2 - https://doi.org/10.1111/j.1464-5491.2004.01405.x DB - PRIME DP - Unbound Medicine ER -