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Needle core biopsy can reliably distinguish between benign and malignant papillary lesions of the breast.
Histopathology. 2005 Mar; 46(3):320-7.H

Abstract

AIMS

To review 21 screen-detected papillary lesions in which the core biopsy findings suggested a papillary lesion and to correlate pathological and radiological findings in order to assess the risks of associated malignancy and the need for surgical intervention. The appropriate management of non-malignant papillary breast lesions detected on needle core biopsy (NCB) is currently uncertain.

METHODS AND RESULTS

Forty-seven papillary breast lesions with a histological diagnosis of papilloma, papilloma with atypical ductal hyperplasia (ADH) or ductal carcinoma in situ (DCIS), multiple papillomas, 'papillomatosis' or papillary carcinoma (invasive or in situ) were identified from records at the Leeds Breast Screening and Assessment Unit. The cases were diagnosed between between May 1995 and May 2002. In 21 cases the previous NCB contained a papillary proliferation which had been categorized as either 'B2', benign, 'B3', of uncertain malignant potential, or 'B4', suspicious of malignancy. All of the 19 'B3' or 'B4' cases and one of the two 'B2' lesions had undergone open surgical biopsy. All cases with a previous 'B4' were malignant on subsequent excision. All excised cases with a previous 'B3' or 'B2' were found benign, although four of the 'B3's derived from papillomata associated with an atypical proliferation amounting to ADH. In three of these four (75%) the papillary proliferation had been associated with epithelial hyperplasia of usual type (HUT) on the core and the radiological features were of a mass lesion detected on incident round screen which had increased in size.

CONCLUSION

Our results confirm the accuracy of NCB in the diagnosis of screen-detected papillary lesions of the breast. Surgical excision may not always be necessary following a 'B3' core biopsy.

Authors+Show Affiliations

Department of Pathology, St James's University Hospital, Leeds, UK. paulinecarder@doctors.org.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15720418

Citation

Carder, P J., et al. "Needle Core Biopsy Can Reliably Distinguish Between Benign and Malignant Papillary Lesions of the Breast." Histopathology, vol. 46, no. 3, 2005, pp. 320-7.
Carder PJ, Garvican J, Haigh I, et al. Needle core biopsy can reliably distinguish between benign and malignant papillary lesions of the breast. Histopathology. 2005;46(3):320-7.
Carder, P. J., Garvican, J., Haigh, I., & Liston, J. C. (2005). Needle core biopsy can reliably distinguish between benign and malignant papillary lesions of the breast. Histopathology, 46(3), 320-7.
Carder PJ, et al. Needle Core Biopsy Can Reliably Distinguish Between Benign and Malignant Papillary Lesions of the Breast. Histopathology. 2005;46(3):320-7. PubMed PMID: 15720418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Needle core biopsy can reliably distinguish between benign and malignant papillary lesions of the breast. AU - Carder,P J, AU - Garvican,J, AU - Haigh,I, AU - Liston,J C, PY - 2005/2/22/pubmed PY - 2005/5/25/medline PY - 2005/2/22/entrez SP - 320 EP - 7 JF - Histopathology JO - Histopathology VL - 46 IS - 3 N2 - AIMS: To review 21 screen-detected papillary lesions in which the core biopsy findings suggested a papillary lesion and to correlate pathological and radiological findings in order to assess the risks of associated malignancy and the need for surgical intervention. The appropriate management of non-malignant papillary breast lesions detected on needle core biopsy (NCB) is currently uncertain. METHODS AND RESULTS: Forty-seven papillary breast lesions with a histological diagnosis of papilloma, papilloma with atypical ductal hyperplasia (ADH) or ductal carcinoma in situ (DCIS), multiple papillomas, 'papillomatosis' or papillary carcinoma (invasive or in situ) were identified from records at the Leeds Breast Screening and Assessment Unit. The cases were diagnosed between between May 1995 and May 2002. In 21 cases the previous NCB contained a papillary proliferation which had been categorized as either 'B2', benign, 'B3', of uncertain malignant potential, or 'B4', suspicious of malignancy. All of the 19 'B3' or 'B4' cases and one of the two 'B2' lesions had undergone open surgical biopsy. All cases with a previous 'B4' were malignant on subsequent excision. All excised cases with a previous 'B3' or 'B2' were found benign, although four of the 'B3's derived from papillomata associated with an atypical proliferation amounting to ADH. In three of these four (75%) the papillary proliferation had been associated with epithelial hyperplasia of usual type (HUT) on the core and the radiological features were of a mass lesion detected on incident round screen which had increased in size. CONCLUSION: Our results confirm the accuracy of NCB in the diagnosis of screen-detected papillary lesions of the breast. Surgical excision may not always be necessary following a 'B3' core biopsy. SN - 0309-0167 UR - https://www.unboundmedicine.com/medline/citation/15720418/Needle_core_biopsy_can_reliably_distinguish_between_benign_and_malignant_papillary_lesions_of_the_breast_ L2 - https://doi.org/10.1111/j.1365-2559.2005.02082.x DB - PRIME DP - Unbound Medicine ER -