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In-vitro evaluation of khaya and albizia gums as compression coatings for drug targeting to the colon.
J Pharm Pharmacol. 2005 Feb; 57(2):163-8.JP

Abstract

Khaya and albizia gums were evaluated as compression coatings for target drug delivery to the colon using indometacin (a water insoluble drug) and paracetamol (a water soluble drug) as model drugs. The core tablets were compression-coated with 300 and 400 mg of 100% khaya gum, 100% albizia gum and a mixture of khaya and albizia gum (1:1). Drug release studies were carried out in 0.1(M) HCl (pH 1.2) for 2 h, Sorensen's buffer (pH 7.4) for 3 h and then in phosphate-buffered saline (pH 6.8) or in simulated colonic fluid for the rest of the experiment to mimic the physiological conditions from the mouth to colon. The results indicated that khaya and albizia gums were capable of protecting the core tablet in the physiological environment of the stomach and small intestine, with albizia gum showing greater ability than khaya gum. The release from tablets coated with the mixture of khaya and albizia gums was midway between the two individual gums, indicating that there was no interaction between the gums. Studies carried out using rat caecal matter in phosphate-buffered saline at pH 6.8 (simulated colonic fluid) showed that the gums were susceptible to degradation by the colonic bacterial enzymes, leading to release of the drug. The results demonstrate that khaya gum and albizia gum have potential for drug targeting to the colon.

Authors+Show Affiliations

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria. pejuodeku@yahoo.comNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15720778

Citation

Odeku, Oluwatoyin A., and John T. Fell. "In-vitro Evaluation of Khaya and Albizia Gums as Compression Coatings for Drug Targeting to the Colon." The Journal of Pharmacy and Pharmacology, vol. 57, no. 2, 2005, pp. 163-8.
Odeku OA, Fell JT. In-vitro evaluation of khaya and albizia gums as compression coatings for drug targeting to the colon. J Pharm Pharmacol. 2005;57(2):163-8.
Odeku, O. A., & Fell, J. T. (2005). In-vitro evaluation of khaya and albizia gums as compression coatings for drug targeting to the colon. The Journal of Pharmacy and Pharmacology, 57(2), 163-8.
Odeku OA, Fell JT. In-vitro Evaluation of Khaya and Albizia Gums as Compression Coatings for Drug Targeting to the Colon. J Pharm Pharmacol. 2005;57(2):163-8. PubMed PMID: 15720778.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In-vitro evaluation of khaya and albizia gums as compression coatings for drug targeting to the colon. AU - Odeku,Oluwatoyin A, AU - Fell,John T, PY - 2005/2/22/pubmed PY - 2005/9/15/medline PY - 2005/2/22/entrez SP - 163 EP - 8 JF - The Journal of pharmacy and pharmacology JO - J Pharm Pharmacol VL - 57 IS - 2 N2 - Khaya and albizia gums were evaluated as compression coatings for target drug delivery to the colon using indometacin (a water insoluble drug) and paracetamol (a water soluble drug) as model drugs. The core tablets were compression-coated with 300 and 400 mg of 100% khaya gum, 100% albizia gum and a mixture of khaya and albizia gum (1:1). Drug release studies were carried out in 0.1(M) HCl (pH 1.2) for 2 h, Sorensen's buffer (pH 7.4) for 3 h and then in phosphate-buffered saline (pH 6.8) or in simulated colonic fluid for the rest of the experiment to mimic the physiological conditions from the mouth to colon. The results indicated that khaya and albizia gums were capable of protecting the core tablet in the physiological environment of the stomach and small intestine, with albizia gum showing greater ability than khaya gum. The release from tablets coated with the mixture of khaya and albizia gums was midway between the two individual gums, indicating that there was no interaction between the gums. Studies carried out using rat caecal matter in phosphate-buffered saline at pH 6.8 (simulated colonic fluid) showed that the gums were susceptible to degradation by the colonic bacterial enzymes, leading to release of the drug. The results demonstrate that khaya gum and albizia gum have potential for drug targeting to the colon. SN - 0022-3573 UR - https://www.unboundmedicine.com/medline/citation/15720778/In_vitro_evaluation_of_khaya_and_albizia_gums_as_compression_coatings_for_drug_targeting_to_the_colon_ DB - PRIME DP - Unbound Medicine ER -