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Circulating malondialdehyde-modified LDL and atherogenic lipoprotein profiles measured by nuclear magnetic resonance spectroscopy in patients with coronary artery disease.
Atherosclerosis 2005; 179(1):139-45A

Abstract

OBJECTIVE

Recent studies have suggested that circulating malondialdehyde-modified low-density lipoprotein (MDA-LDL) is a useful marker for the identification of patients with coronary artery disease (CAD). However, the role of MDA-LDL in atherogenic mechanisms has not yet been fully determined.

METHOD AND RESULTS

We investigated lipoprotein profiles measured by nuclear magnetic resonance (NMR) spectroscopy and circulating MDA-LDL levels measured by ELISA in 25 male patients with CAD and 15 age-matched male controls. We selected subjects who had a serum LDL cholesterol<160 mg/dL. The MDA-LDL levels were significantly higher in the CAD group than in the control group (P=0.01) even though there was no significant difference in the LDL cholesterol levels between the two groups. NMR analysis demonstrated that the MDA-LDL levels were positively correlated with large and intermediate very low-density lipoprotein triglyceride and LDL particle concentrations, and negatively correlated with LDL diameter and large high-density lipoprotein cholesterol. The MDA-LDL levels were negatively correlated with flow-mediated dilatation of the brachial artery.

CONCLUSIONS

The high concentrations of circulating MDA-LDL derived from the atherogenic lipoprotein profiles, which induce the exaggerated production of small dense LDL. The circulating MDA-LDL may impair endothelial function and play an important role in the pathogenesis of atherosclerosis.

Authors+Show Affiliations

Department of Cardiology, Juntendo University School of Medicine, 2-1-1 Hongo Bunkyo-ku, Tokyo 113-8421, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15721020

Citation

Miyazaki, Tetsuro, et al. "Circulating Malondialdehyde-modified LDL and Atherogenic Lipoprotein Profiles Measured By Nuclear Magnetic Resonance Spectroscopy in Patients With Coronary Artery Disease." Atherosclerosis, vol. 179, no. 1, 2005, pp. 139-45.
Miyazaki T, Shimada K, Sato O, et al. Circulating malondialdehyde-modified LDL and atherogenic lipoprotein profiles measured by nuclear magnetic resonance spectroscopy in patients with coronary artery disease. Atherosclerosis. 2005;179(1):139-45.
Miyazaki, T., Shimada, K., Sato, O., Kotani, K., Kume, A., Sumiyoshi, K., ... Daida, H. (2005). Circulating malondialdehyde-modified LDL and atherogenic lipoprotein profiles measured by nuclear magnetic resonance spectroscopy in patients with coronary artery disease. Atherosclerosis, 179(1), pp. 139-45.
Miyazaki T, et al. Circulating Malondialdehyde-modified LDL and Atherogenic Lipoprotein Profiles Measured By Nuclear Magnetic Resonance Spectroscopy in Patients With Coronary Artery Disease. Atherosclerosis. 2005;179(1):139-45. PubMed PMID: 15721020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating malondialdehyde-modified LDL and atherogenic lipoprotein profiles measured by nuclear magnetic resonance spectroscopy in patients with coronary artery disease. AU - Miyazaki,Tetsuro, AU - Shimada,Kazunori, AU - Sato,Osamu, AU - Kotani,Kazuo, AU - Kume,Atsumi, AU - Sumiyoshi,Katsuhiko, AU - Sato,Yayoi, AU - Ohmura,Hirotoshi, AU - Watanabe,Yoshiro, AU - Mokuno,Hiroshi, AU - Daida,Hiroyuki, Y1 - 2004/11/13/ PY - 2004/04/28/received PY - 2004/08/11/revised PY - 2004/09/16/accepted PY - 2005/2/22/pubmed PY - 2005/6/23/medline PY - 2005/2/22/entrez SP - 139 EP - 45 JF - Atherosclerosis JO - Atherosclerosis VL - 179 IS - 1 N2 - OBJECTIVE: Recent studies have suggested that circulating malondialdehyde-modified low-density lipoprotein (MDA-LDL) is a useful marker for the identification of patients with coronary artery disease (CAD). However, the role of MDA-LDL in atherogenic mechanisms has not yet been fully determined. METHOD AND RESULTS: We investigated lipoprotein profiles measured by nuclear magnetic resonance (NMR) spectroscopy and circulating MDA-LDL levels measured by ELISA in 25 male patients with CAD and 15 age-matched male controls. We selected subjects who had a serum LDL cholesterol<160 mg/dL. The MDA-LDL levels were significantly higher in the CAD group than in the control group (P=0.01) even though there was no significant difference in the LDL cholesterol levels between the two groups. NMR analysis demonstrated that the MDA-LDL levels were positively correlated with large and intermediate very low-density lipoprotein triglyceride and LDL particle concentrations, and negatively correlated with LDL diameter and large high-density lipoprotein cholesterol. The MDA-LDL levels were negatively correlated with flow-mediated dilatation of the brachial artery. CONCLUSIONS: The high concentrations of circulating MDA-LDL derived from the atherogenic lipoprotein profiles, which induce the exaggerated production of small dense LDL. The circulating MDA-LDL may impair endothelial function and play an important role in the pathogenesis of atherosclerosis. SN - 0021-9150 UR - https://www.unboundmedicine.com/medline/citation/15721020/Circulating_malondialdehyde_modified_LDL_and_atherogenic_lipoprotein_profiles_measured_by_nuclear_magnetic_resonance_spectroscopy_in_patients_with_coronary_artery_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(04)00502-7 DB - PRIME DP - Unbound Medicine ER -