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ACE I/D polymorphism is a risk factor of Alzheimer's disease but not of vascular dementia.
Neurosci Lett 2005; 377(1):37-9NL

Abstract

Different studies have investigated the effect of the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism on the risk of Alzheimer dementia (AD). However, results on the association of the ACE-I allele with AD have been inconclusive. A recent meta-analysis reported an association of the I-allele with the risk of AD. A few small studies also investigated the effect of ACE polymorphism on the risk of vascular dementia (VD). We have investigated the effect of ACE I/D polymorphism in 351 AD and 155 VD patients and 348 healthy controls. We found the I/I genotype to be associated with an increased risk of AD, but not with the risk of VD. Cell-specific effects of ACE polymorphism are suggested, additional studies on neuronal cells might help to understand the role of this polymorphism in AD.

Authors+Show Affiliations

Department of Psychiatry, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. heike.koelsch@ukb.uni-bonn.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15722183

Citation

Kölsch, H, et al. "ACE I/D Polymorphism Is a Risk Factor of Alzheimer's Disease but Not of Vascular Dementia." Neuroscience Letters, vol. 377, no. 1, 2005, pp. 37-9.
Kölsch H, Jessen F, Freymann N, et al. ACE I/D polymorphism is a risk factor of Alzheimer's disease but not of vascular dementia. Neurosci Lett. 2005;377(1):37-9.
Kölsch, H., Jessen, F., Freymann, N., Kreis, M., Hentschel, F., Maier, W., & Heun, R. (2005). ACE I/D polymorphism is a risk factor of Alzheimer's disease but not of vascular dementia. Neuroscience Letters, 377(1), pp. 37-9.
Kölsch H, et al. ACE I/D Polymorphism Is a Risk Factor of Alzheimer's Disease but Not of Vascular Dementia. Neurosci Lett. 2005 Mar 22;377(1):37-9. PubMed PMID: 15722183.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ACE I/D polymorphism is a risk factor of Alzheimer's disease but not of vascular dementia. AU - Kölsch,H, AU - Jessen,F, AU - Freymann,N, AU - Kreis,M, AU - Hentschel,F, AU - Maier,W, AU - Heun,R, Y1 - 2004/12/10/ PY - 2004/08/18/received PY - 2004/11/19/revised PY - 2004/11/22/accepted PY - 2005/2/22/pubmed PY - 2005/4/16/medline PY - 2005/2/22/entrez SP - 37 EP - 9 JF - Neuroscience letters JO - Neurosci. Lett. VL - 377 IS - 1 N2 - Different studies have investigated the effect of the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism on the risk of Alzheimer dementia (AD). However, results on the association of the ACE-I allele with AD have been inconclusive. A recent meta-analysis reported an association of the I-allele with the risk of AD. A few small studies also investigated the effect of ACE polymorphism on the risk of vascular dementia (VD). We have investigated the effect of ACE I/D polymorphism in 351 AD and 155 VD patients and 348 healthy controls. We found the I/I genotype to be associated with an increased risk of AD, but not with the risk of VD. Cell-specific effects of ACE polymorphism are suggested, additional studies on neuronal cells might help to understand the role of this polymorphism in AD. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/15722183/ACE_I/D_polymorphism_is_a_risk_factor_of_Alzheimer's_disease_but_not_of_vascular_dementia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(04)01477-6 DB - PRIME DP - Unbound Medicine ER -