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Regulation of striatal preproenkephalin mRNA levels in MPTP-lesioned mice treated with estradiol.
J Neurosci Res. 2005 Apr 01; 80(1):138-44.JN

Abstract

We reported previously the protective effect of 17beta-estradiol (17beta-E(2)) on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopamine (DA) depletion. This protection was stereospecific, because 17beta-E(2) showed activity but 17alpha-estradiol (17alpha-E(2)) did not. The mechanisms by which estradiol exerts its beneficial effects, however, remain unknown. We investigated a possible implication of enkephalins (ENK) in neuroprotective activity of 17beta-E(2). Protection against MPTP-induced DA depletion was obtained with 17beta-E(2) but not 17alpha-E(2). MPTP lesion increased striatal preproenkephalin (PPE) mRNA levels and they remained elevated in 17alpha-E(2)-treated MPTP mice whereas 17beta-E(2) treatment decreased these levels to control values. This is the first report of estradiol modulation of striatal PPE mRNA in mice. Negative and significant correlations between DA levels, vesicular monoamine transporter (VMAT(2)) density, and PPE mRNA were observed in the striatum of lesioned animals. This effect of 17beta-E(2) on PPE mRNA after a lesion could be one of many mechanisms by which this steroid exerts its neuroprotective activity.

Authors+Show Affiliations

Molecular Endocrinology and Oncology Research Center, Laval University Medical Center, CHUL, Quebec City, Quebec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15723346

Citation

D'Astous, Myreille, et al. "Regulation of Striatal Preproenkephalin mRNA Levels in MPTP-lesioned Mice Treated With Estradiol." Journal of Neuroscience Research, vol. 80, no. 1, 2005, pp. 138-44.
D'Astous M, Morissette M, Callier S, et al. Regulation of striatal preproenkephalin mRNA levels in MPTP-lesioned mice treated with estradiol. J Neurosci Res. 2005;80(1):138-44.
D'Astous, M., Morissette, M., Callier, S., & Di Paolo, T. (2005). Regulation of striatal preproenkephalin mRNA levels in MPTP-lesioned mice treated with estradiol. Journal of Neuroscience Research, 80(1), 138-44.
D'Astous M, et al. Regulation of Striatal Preproenkephalin mRNA Levels in MPTP-lesioned Mice Treated With Estradiol. J Neurosci Res. 2005 Apr 1;80(1):138-44. PubMed PMID: 15723346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of striatal preproenkephalin mRNA levels in MPTP-lesioned mice treated with estradiol. AU - D'Astous,Myreille, AU - Morissette,Marc, AU - Callier,Sophie, AU - Di Paolo,Thérèse, PY - 2005/2/22/pubmed PY - 2005/5/27/medline PY - 2005/2/22/entrez SP - 138 EP - 44 JF - Journal of neuroscience research JO - J Neurosci Res VL - 80 IS - 1 N2 - We reported previously the protective effect of 17beta-estradiol (17beta-E(2)) on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopamine (DA) depletion. This protection was stereospecific, because 17beta-E(2) showed activity but 17alpha-estradiol (17alpha-E(2)) did not. The mechanisms by which estradiol exerts its beneficial effects, however, remain unknown. We investigated a possible implication of enkephalins (ENK) in neuroprotective activity of 17beta-E(2). Protection against MPTP-induced DA depletion was obtained with 17beta-E(2) but not 17alpha-E(2). MPTP lesion increased striatal preproenkephalin (PPE) mRNA levels and they remained elevated in 17alpha-E(2)-treated MPTP mice whereas 17beta-E(2) treatment decreased these levels to control values. This is the first report of estradiol modulation of striatal PPE mRNA in mice. Negative and significant correlations between DA levels, vesicular monoamine transporter (VMAT(2)) density, and PPE mRNA were observed in the striatum of lesioned animals. This effect of 17beta-E(2) on PPE mRNA after a lesion could be one of many mechanisms by which this steroid exerts its neuroprotective activity. SN - 0360-4012 UR - https://www.unboundmedicine.com/medline/citation/15723346/Regulation_of_striatal_preproenkephalin_mRNA_levels_in_MPTP_lesioned_mice_treated_with_estradiol_ L2 - https://doi.org/10.1002/jnr.20412 DB - PRIME DP - Unbound Medicine ER -