Tags

Type your tag names separated by a space and hit enter

Racial and ethnic distribution of nonalcoholic fatty liver in persons with newly diagnosed chronic liver disease.
Hepatology. 2005 Feb; 41(2):372-9.Hep

Abstract

We performed a cross-sectional study of newly diagnosed cases of nonalcoholic fatty liver disease (NAFLD) identified between December 1998 and December 2000 in the Chronic Liver Disease Surveillance Study. We compared the demographic and clinical features of NAFLD in a racially diverse representative U.S. population (Alameda County, CA). Diagnostic criteria for probable NAFLD were persistent unexplained elevation of serum aminotransferase levels, radiology (ultrasound or computed tomography scan) consistent with fatty liver, and/or two or more of the following: (i) body mass index of 28 kg/m(2) or more, (ii) type 2 diabetes, or (iii) hyperlipidemia, in the absence of significant alcohol use. Definite NAFLD cases required histological confirmation. Of the 742 persons with newly diagnosed chronic liver disease, 159 (21.4%) had definite or probable NAFLD. The majority were nonwhite: Hispanics (28%), Asians (18%), African Americans (3%), and other race(s) (6%). African Americans with NAFLD were significantly older than other racial or ethnic groups (P < .001), and in Asians, NAFLD was 3.5 times more common in males than in females (P = .016). Clinical correlates of NAFLD (obesity, hyperlipidemia, diabetes) were similar among racial and ethnic groups, except that body mass index was lower in Asians compared with other groups (P < .001). Compared with the base population (Kaiser Permanente members), Hispanics with NAFLD were overrepresented (28% vs. 10%) and whites were underrepresented (45% vs. 59%). In conclusion, these racial and gender variations may reflect differences in genetic susceptibility to visceral adiposity, including hepatic involvement, and may have implications for the evaluation of persons with the metabolic syndrome. Clinicians need to be aware of the variable presentations of NAFLD in different racial and ethnic groups.

Authors+Show Affiliations

Department of Medicine, University of California at San Francisco, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15723436

Citation

Weston, Shiobhan R., et al. "Racial and Ethnic Distribution of Nonalcoholic Fatty Liver in Persons With Newly Diagnosed Chronic Liver Disease." Hepatology (Baltimore, Md.), vol. 41, no. 2, 2005, pp. 372-9.
Weston SR, Leyden W, Murphy R, et al. Racial and ethnic distribution of nonalcoholic fatty liver in persons with newly diagnosed chronic liver disease. Hepatology. 2005;41(2):372-9.
Weston, S. R., Leyden, W., Murphy, R., Bass, N. M., Bell, B. P., Manos, M. M., & Terrault, N. A. (2005). Racial and ethnic distribution of nonalcoholic fatty liver in persons with newly diagnosed chronic liver disease. Hepatology (Baltimore, Md.), 41(2), 372-9.
Weston SR, et al. Racial and Ethnic Distribution of Nonalcoholic Fatty Liver in Persons With Newly Diagnosed Chronic Liver Disease. Hepatology. 2005;41(2):372-9. PubMed PMID: 15723436.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Racial and ethnic distribution of nonalcoholic fatty liver in persons with newly diagnosed chronic liver disease. AU - Weston,Shiobhan R, AU - Leyden,Wendy, AU - Murphy,Rose, AU - Bass,Nathan M, AU - Bell,Beth P, AU - Manos,M Michele, AU - Terrault,Norah A, PY - 2005/2/22/pubmed PY - 2005/3/11/medline PY - 2005/2/22/entrez SP - 372 EP - 9 JF - Hepatology (Baltimore, Md.) JO - Hepatology VL - 41 IS - 2 N2 - We performed a cross-sectional study of newly diagnosed cases of nonalcoholic fatty liver disease (NAFLD) identified between December 1998 and December 2000 in the Chronic Liver Disease Surveillance Study. We compared the demographic and clinical features of NAFLD in a racially diverse representative U.S. population (Alameda County, CA). Diagnostic criteria for probable NAFLD were persistent unexplained elevation of serum aminotransferase levels, radiology (ultrasound or computed tomography scan) consistent with fatty liver, and/or two or more of the following: (i) body mass index of 28 kg/m(2) or more, (ii) type 2 diabetes, or (iii) hyperlipidemia, in the absence of significant alcohol use. Definite NAFLD cases required histological confirmation. Of the 742 persons with newly diagnosed chronic liver disease, 159 (21.4%) had definite or probable NAFLD. The majority were nonwhite: Hispanics (28%), Asians (18%), African Americans (3%), and other race(s) (6%). African Americans with NAFLD were significantly older than other racial or ethnic groups (P < .001), and in Asians, NAFLD was 3.5 times more common in males than in females (P = .016). Clinical correlates of NAFLD (obesity, hyperlipidemia, diabetes) were similar among racial and ethnic groups, except that body mass index was lower in Asians compared with other groups (P < .001). Compared with the base population (Kaiser Permanente members), Hispanics with NAFLD were overrepresented (28% vs. 10%) and whites were underrepresented (45% vs. 59%). In conclusion, these racial and gender variations may reflect differences in genetic susceptibility to visceral adiposity, including hepatic involvement, and may have implications for the evaluation of persons with the metabolic syndrome. Clinicians need to be aware of the variable presentations of NAFLD in different racial and ethnic groups. SN - 0270-9139 UR - https://www.unboundmedicine.com/medline/citation/15723436/Racial_and_ethnic_distribution_of_nonalcoholic_fatty_liver_in_persons_with_newly_diagnosed_chronic_liver_disease_ L2 - https://doi.org/10.1002/hep.20554 DB - PRIME DP - Unbound Medicine ER -