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Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via "imported" nitric oxide synthase activity.
Circulation. 2005 Mar 08; 111(9):1114-20.Circ

Abstract

BACKGROUND

The function of bone marrow-derived endothelial progenitor cells (EPCs) in repair of ischemic tissue has been the subject of intense scrutiny, and the capacity of these cells to contribute significantly to new blood vessels remains controversial. The possibility that EPCs could act as reservoirs of cytokines has been implied by several observations; however, a specific role for cytokine delivery has not been identified.

METHODS AND RESULTS

We performed a series of experiments that revealed the rapid recruitment of EPCs to the myocardium by very short periods of ischemia, so-called ischemic preconditioning. The recruited EPCs express an array of potentially cardioprotective cytokines including nitric oxide synthase isoforms. Bone marrow transplantation studies, using donor marrow null for nitric oxide synthase isoforms, revealed that both endothelial and inducible nitric oxide synthase derived from bone marrow cells play essential roles in the cardioprotective effect that normally occurs after ischemic preconditioning.

CONCLUSIONS

These findings provide novel insights about the role of bone marrow-derived cells in ischemic preconditioning and also reveal that distinct mechanisms regulate recovery after ischemia-reperfusion and chronic ischemic injury.

Authors+Show Affiliations

Division of Cardiovascular Research, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15723985

Citation

Ii, Masaaki, et al. "Endothelial Progenitor Cells Are Rapidly Recruited to Myocardium and Mediate Protective Effect of Ischemic Preconditioning Via "imported" Nitric Oxide Synthase Activity." Circulation, vol. 111, no. 9, 2005, pp. 1114-20.
Ii M, Nishimura H, Iwakura A, et al. Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via "imported" nitric oxide synthase activity. Circulation. 2005;111(9):1114-20.
Ii, M., Nishimura, H., Iwakura, A., Wecker, A., Eaton, E., Asahara, T., & Losordo, D. W. (2005). Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via "imported" nitric oxide synthase activity. Circulation, 111(9), 1114-20.
Ii M, et al. Endothelial Progenitor Cells Are Rapidly Recruited to Myocardium and Mediate Protective Effect of Ischemic Preconditioning Via "imported" Nitric Oxide Synthase Activity. Circulation. 2005 Mar 8;111(9):1114-20. PubMed PMID: 15723985.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via "imported" nitric oxide synthase activity. AU - Ii,Masaaki, AU - Nishimura,Hiromi, AU - Iwakura,Atsushi, AU - Wecker,Andrea, AU - Eaton,Elizabeth, AU - Asahara,Takayuki, AU - Losordo,Douglas W, Y1 - 2005/02/21/ PY - 2005/2/23/pubmed PY - 2005/10/19/medline PY - 2005/2/23/entrez SP - 1114 EP - 20 JF - Circulation JO - Circulation VL - 111 IS - 9 N2 - BACKGROUND: The function of bone marrow-derived endothelial progenitor cells (EPCs) in repair of ischemic tissue has been the subject of intense scrutiny, and the capacity of these cells to contribute significantly to new blood vessels remains controversial. The possibility that EPCs could act as reservoirs of cytokines has been implied by several observations; however, a specific role for cytokine delivery has not been identified. METHODS AND RESULTS: We performed a series of experiments that revealed the rapid recruitment of EPCs to the myocardium by very short periods of ischemia, so-called ischemic preconditioning. The recruited EPCs express an array of potentially cardioprotective cytokines including nitric oxide synthase isoforms. Bone marrow transplantation studies, using donor marrow null for nitric oxide synthase isoforms, revealed that both endothelial and inducible nitric oxide synthase derived from bone marrow cells play essential roles in the cardioprotective effect that normally occurs after ischemic preconditioning. CONCLUSIONS: These findings provide novel insights about the role of bone marrow-derived cells in ischemic preconditioning and also reveal that distinct mechanisms regulate recovery after ischemia-reperfusion and chronic ischemic injury. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/15723985/Endothelial_progenitor_cells_are_rapidly_recruited_to_myocardium_and_mediate_protective_effect_of_ischemic_preconditioning_via_"imported"_nitric_oxide_synthase_activity_ L2 - https://www.ahajournals.org/doi/10.1161/01.CIR.0000157144.24888.7E?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -