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[New approach in the diagnosis and monitoring of treatment in chronic myelogenous leukemia].
Orv Hetil 2004; 145(52):2603-9OH

Abstract

The chronic myelogenous leukemia is a pluripotent hemopoietic stem cell disease characterized by the t(9;22) (q34;q11) reciprocal chromosomal translocation (Philadelphia chromosome). The translocation result the fusion of the ABL gene located at the long arm of chromosome 9 with the BCR gene located at the long arm of chromosome 22. The BCR/ABL fusion gene encodes a chimeric protein with elevated tyrosine kinase activity, that plays an important role in the pathogenesis of the disease. In the diagnosis of chronic myelogenous leukemia and in the evaluation of the therapeutic effect, the detection of the t(9;22)(q34;q11) translocation and BCR/ABL fusion gene plays an important role. The authors in the present paper provides a review on the recently used methods of the detection of t(9;22)(q34;q11) chromosomal translocation and BCR/ABL fusion gene and their role in the diagnosis, monitoring and evaluation of therapeutic effect in chronic myelogenous leukemia.

Authors+Show Affiliations

Semmelweis Egyetem, Altalános Orvostudományi Kar, I. Patológiai és Kísérleti Rákkutató Intézet, Budapest.

Pub Type(s)

English Abstract
Journal Article
Review

Language

hun

PubMed ID

15724695

Citation

Matolcsy, András. "[New Approach in the Diagnosis and Monitoring of Treatment in Chronic Myelogenous Leukemia]." Orvosi Hetilap, vol. 145, no. 52, 2004, pp. 2603-9.
Matolcsy A. [New approach in the diagnosis and monitoring of treatment in chronic myelogenous leukemia]. Orv Hetil. 2004;145(52):2603-9.
Matolcsy, A. (2004). [New approach in the diagnosis and monitoring of treatment in chronic myelogenous leukemia]. Orvosi Hetilap, 145(52), pp. 2603-9.
Matolcsy A. [New Approach in the Diagnosis and Monitoring of Treatment in Chronic Myelogenous Leukemia]. Orv Hetil. 2004 Dec 26;145(52):2603-9. PubMed PMID: 15724695.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [New approach in the diagnosis and monitoring of treatment in chronic myelogenous leukemia]. A1 - Matolcsy,András, PY - 2005/2/24/pubmed PY - 2005/3/9/medline PY - 2005/2/24/entrez SP - 2603 EP - 9 JF - Orvosi hetilap JO - Orv Hetil VL - 145 IS - 52 N2 - The chronic myelogenous leukemia is a pluripotent hemopoietic stem cell disease characterized by the t(9;22) (q34;q11) reciprocal chromosomal translocation (Philadelphia chromosome). The translocation result the fusion of the ABL gene located at the long arm of chromosome 9 with the BCR gene located at the long arm of chromosome 22. The BCR/ABL fusion gene encodes a chimeric protein with elevated tyrosine kinase activity, that plays an important role in the pathogenesis of the disease. In the diagnosis of chronic myelogenous leukemia and in the evaluation of the therapeutic effect, the detection of the t(9;22)(q34;q11) translocation and BCR/ABL fusion gene plays an important role. The authors in the present paper provides a review on the recently used methods of the detection of t(9;22)(q34;q11) chromosomal translocation and BCR/ABL fusion gene and their role in the diagnosis, monitoring and evaluation of therapeutic effect in chronic myelogenous leukemia. SN - 0030-6002 UR - https://www.unboundmedicine.com/medline/citation/15724695/[New_approach_in_the_diagnosis_and_monitoring_of_treatment_in_chronic_myelogenous_leukemia]_ L2 - https://medlineplus.gov/chronicmyeloidleukemia.html DB - PRIME DP - Unbound Medicine ER -