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Particle size distribution and evolution in tablet structure during and after compaction.
Int J Pharm. 2005 Mar 23; 292(1-2):211-25.IJ

Abstract

The objective of this study was to investigate the effect of the distribution in size of free-flowing particles for the evolution in tablet structure and tablet strength. For sucrose and sodium chloride, three powders of different size distributions were prepared by mixing predetermined quantities of particle size fractions. For paracetamol, three batches with varying particle size distributions were prepared by crystallisation. The powders were formed into tablets. Tablet porosity and tensile strength were determined directly after compaction and after short-term storage at two different relative humidities. Tablets were also formed after admixture of a lubricant (magnesium stearate) and the tablet tensile strength was determined. For the test materials used in this study, the spread in particle size had no influence on the evolution in tablet porosity and tensile strength during compression. However, the spread in particle size had a significant and complex influence on the short-term post-compaction increase in tablet tensile strength. The effect of the spread was related to the instability mechanism and the presence of lubricant. It is concluded that the distribution in size of free-flowing particles is not critical for the tablet porosity but may give significant effects on tablet tensile strength due to a post-compaction reaction.

Authors+Show Affiliations

Department of Pharmacy, Uppsala University, Box 580, SE-751 23 Uppsala, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15725568

Citation

Fichtner, Frauke, et al. "Particle Size Distribution and Evolution in Tablet Structure During and After Compaction." International Journal of Pharmaceutics, vol. 292, no. 1-2, 2005, pp. 211-25.
Fichtner F, Rasmuson A, Alderborn G. Particle size distribution and evolution in tablet structure during and after compaction. Int J Pharm. 2005;292(1-2):211-25.
Fichtner, F., Rasmuson, A., & Alderborn, G. (2005). Particle size distribution and evolution in tablet structure during and after compaction. International Journal of Pharmaceutics, 292(1-2), 211-25.
Fichtner F, Rasmuson A, Alderborn G. Particle Size Distribution and Evolution in Tablet Structure During and After Compaction. Int J Pharm. 2005 Mar 23;292(1-2):211-25. PubMed PMID: 15725568.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Particle size distribution and evolution in tablet structure during and after compaction. AU - Fichtner,Frauke, AU - Rasmuson,Ake, AU - Alderborn,Göran, Y1 - 2005/01/26/ PY - 2004/07/19/received PY - 2004/12/13/revised PY - 2004/12/20/accepted PY - 2005/2/24/pubmed PY - 2005/12/15/medline PY - 2005/2/24/entrez SP - 211 EP - 25 JF - International journal of pharmaceutics JO - Int J Pharm VL - 292 IS - 1-2 N2 - The objective of this study was to investigate the effect of the distribution in size of free-flowing particles for the evolution in tablet structure and tablet strength. For sucrose and sodium chloride, three powders of different size distributions were prepared by mixing predetermined quantities of particle size fractions. For paracetamol, three batches with varying particle size distributions were prepared by crystallisation. The powders were formed into tablets. Tablet porosity and tensile strength were determined directly after compaction and after short-term storage at two different relative humidities. Tablets were also formed after admixture of a lubricant (magnesium stearate) and the tablet tensile strength was determined. For the test materials used in this study, the spread in particle size had no influence on the evolution in tablet porosity and tensile strength during compression. However, the spread in particle size had a significant and complex influence on the short-term post-compaction increase in tablet tensile strength. The effect of the spread was related to the instability mechanism and the presence of lubricant. It is concluded that the distribution in size of free-flowing particles is not critical for the tablet porosity but may give significant effects on tablet tensile strength due to a post-compaction reaction. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/15725568/Particle_size_distribution_and_evolution_in_tablet_structure_during_and_after_compaction_ DB - PRIME DP - Unbound Medicine ER -