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Medicinal mushroom modulators of molecular targets as cancer therapeutics.
Appl Microbiol Biotechnol. 2005 Jun; 67(4):453-68.AM

Abstract

Empirical approaches to discover anticancer drugs and cancer treatments have made limited progress in the past several decades in finding a cure for cancer. The expanded knowledge of the molecular basis of tumorigenesis and metastasis, together with the inherently vast structural diversity of natural compounds found in mushrooms, provided unique opportunities for discovering new drugs that rationally target the abnormal molecular and biochemical signals leading to cancer. This review focuses on mushroom low-molecular-weight secondary metabolites targeting processes such as apoptosis, angiogenesis, metastasis, cell cycle regulation, and signal transduction cascades. Also discussed in this review are high-molecular-weight polysaccharides or polysaccharide-protein complexes from mushrooms that appear to enhance innate and cell-mediated immune responses, exhibit antitumor activities in animals and humans, and demonstrate the anticancer properties of selenium compounds accumulated in mushrooms.

Authors+Show Affiliations

Zaidman BZ
Biodiversity and Biotechnology Center of Cryptogamic Plants and Fungi, The Institute of Evolution, University of Haifa, Mount Carmel, Israel.
Yassin M
No affiliation info available
Mahajna J
No affiliation info available
Wasser SP
No affiliation info available

MeSH

AgaricalesAnimalsAntineoplastic AgentsCell Line, TumorFungal ProteinsHumansNeoplasm ProteinsNeoplasmsPolysaccharides

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15726350

Citation

Zaidman, Ben-Zion, et al. "Medicinal Mushroom Modulators of Molecular Targets as Cancer Therapeutics." Applied Microbiology and Biotechnology, vol. 67, no. 4, 2005, pp. 453-68.
Zaidman BZ, Yassin M, Mahajna J, et al. Medicinal mushroom modulators of molecular targets as cancer therapeutics. Appl Microbiol Biotechnol. 2005;67(4):453-68.
Zaidman, B. Z., Yassin, M., Mahajna, J., & Wasser, S. P. (2005). Medicinal mushroom modulators of molecular targets as cancer therapeutics. Applied Microbiology and Biotechnology, 67(4), 453-68.
Zaidman BZ, et al. Medicinal Mushroom Modulators of Molecular Targets as Cancer Therapeutics. Appl Microbiol Biotechnol. 2005;67(4):453-68. PubMed PMID: 15726350.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Medicinal mushroom modulators of molecular targets as cancer therapeutics. AU - Zaidman,Ben-Zion, AU - Yassin,Majed, AU - Mahajna,Jamal, AU - Wasser,Solomon P, Y1 - 2005/02/23/ PY - 2004/07/13/received PY - 2004/10/02/accepted PY - 2004/09/27/revised PY - 2005/2/24/pubmed PY - 2005/8/3/medline PY - 2005/2/24/entrez SP - 453 EP - 68 JF - Applied microbiology and biotechnology JO - Appl Microbiol Biotechnol VL - 67 IS - 4 N2 - Empirical approaches to discover anticancer drugs and cancer treatments have made limited progress in the past several decades in finding a cure for cancer. The expanded knowledge of the molecular basis of tumorigenesis and metastasis, together with the inherently vast structural diversity of natural compounds found in mushrooms, provided unique opportunities for discovering new drugs that rationally target the abnormal molecular and biochemical signals leading to cancer. This review focuses on mushroom low-molecular-weight secondary metabolites targeting processes such as apoptosis, angiogenesis, metastasis, cell cycle regulation, and signal transduction cascades. Also discussed in this review are high-molecular-weight polysaccharides or polysaccharide-protein complexes from mushrooms that appear to enhance innate and cell-mediated immune responses, exhibit antitumor activities in animals and humans, and demonstrate the anticancer properties of selenium compounds accumulated in mushrooms. SN - 0175-7598 UR - https://www.unboundmedicine.com/medline/citation/15726350/Medicinal_mushroom_modulators_of_molecular_targets_as_cancer_therapeutics_ DB - PRIME DP - Unbound Medicine ER -