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One year soy protein supplementation has positive effects on bone formation markers but not bone density in postmenopausal women.

Abstract

BACKGROUND

Although soy protein and its isoflavones have been reported to reduce the risk of osteoporosis in peri- and post-menopausal women, most of these studies are of short duration (i.e. six months). The objective of this study was to examine if one year consumption of soy-containing foods (providing 25 g protein and 60 mg isoflavones) exerts beneficial effects on bone in postmenopausal women.

METHODS

Eighty-seven eligible postmenopausal women were randomly assigned to consume soy or control foods daily for one year. Bone mineral density (BMD) and bone mineral content (BMC) of the whole body, lumbar (L1-L4), and total hip were measured using dual energy x-ray absorptiometry at baseline and after one year. Blood and urine markers of bone metabolism were also assessed.

RESULTS AND DISCUSSION

Sixty-two subjects completed the one-year long study. Whole body and lumbar BMD and BMC were significantly decreased in both the soy and control groups. However, there were no significant changes in total hip BMD and BMC irrespective of treatment. Both treatments positively affected markers of bone formation as indicated by increased serum bone-specific alkaline phosphatase (BSAP) activity, insulin-like growth factor-I (IGF-I), and osteocalcin (BSAP: 27.8 and 25.8%, IGF-I: 12.8 and 26.3%, osteocalcin: 95.2 and 103.4% for control and soy groups, respectively). Neither of the protein supplements had any effect on urinary deoxypyridinoline excretion, a marker of bone resorption.

CONCLUSION

Our findings suggest that although one year supplementation of 25 g protein per se positively modulated markers of bone formation, this amount of protein was unable to prevent lumbar and whole body bone loss in postmenopausal women.

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  • Authors+Show Affiliations

    ,

    Department of Nutritional Sciences, Oklahoma State University, Stillwater, Oklahoma 74078, USA. arjmand@okstate.edu

    , , , , , , ,

    Source

    Nutrition journal 4: 2005 Feb 23 pg 8

    MeSH

    Absorptiometry, Photon
    Alkaline Phosphatase
    Amino Acids
    Biomarkers
    Body Mass Index
    Bone Density
    Calcium
    Diet
    Diet Records
    Dietary Carbohydrates
    Dietary Proteins
    Double-Blind Method
    Energy Intake
    Female
    Humans
    Insulin-Like Growth Factor I
    Lumbar Vertebrae
    Middle Aged
    Nutritional Physiological Phenomena
    Osteocalcin
    Osteogenesis
    Pelvic Bones
    Postmenopause
    Soybean Proteins
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15727682

    Citation

    Arjmandi, Bahram H., et al. "One Year Soy Protein Supplementation Has Positive Effects On Bone Formation Markers but Not Bone Density in Postmenopausal Women." Nutrition Journal, vol. 4, 2005, p. 8.
    Arjmandi BH, Lucas EA, Khalil DA, et al. One year soy protein supplementation has positive effects on bone formation markers but not bone density in postmenopausal women. Nutr J. 2005;4:8.
    Arjmandi, B. H., Lucas, E. A., Khalil, D. A., Devareddy, L., Smith, B. J., McDonald, J., ... Mason, C. (2005). One year soy protein supplementation has positive effects on bone formation markers but not bone density in postmenopausal women. Nutrition Journal, 4, p. 8.
    Arjmandi BH, et al. One Year Soy Protein Supplementation Has Positive Effects On Bone Formation Markers but Not Bone Density in Postmenopausal Women. Nutr J. 2005 Feb 23;4:8. PubMed PMID: 15727682.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - One year soy protein supplementation has positive effects on bone formation markers but not bone density in postmenopausal women. AU - Arjmandi,Bahram H, AU - Lucas,Edralin A, AU - Khalil,Dania A, AU - Devareddy,Latha, AU - Smith,Brenda J, AU - McDonald,Jennifer, AU - Arquitt,Andrea B, AU - Payton,Mark E, AU - Mason,Claudia, Y1 - 2005/02/23/ PY - 2004/12/21/received PY - 2005/02/23/accepted PY - 2005/2/25/pubmed PY - 2006/7/14/medline PY - 2005/2/25/entrez SP - 8 EP - 8 JF - Nutrition journal JO - Nutr J VL - 4 N2 - BACKGROUND: Although soy protein and its isoflavones have been reported to reduce the risk of osteoporosis in peri- and post-menopausal women, most of these studies are of short duration (i.e. six months). The objective of this study was to examine if one year consumption of soy-containing foods (providing 25 g protein and 60 mg isoflavones) exerts beneficial effects on bone in postmenopausal women. METHODS: Eighty-seven eligible postmenopausal women were randomly assigned to consume soy or control foods daily for one year. Bone mineral density (BMD) and bone mineral content (BMC) of the whole body, lumbar (L1-L4), and total hip were measured using dual energy x-ray absorptiometry at baseline and after one year. Blood and urine markers of bone metabolism were also assessed. RESULTS AND DISCUSSION: Sixty-two subjects completed the one-year long study. Whole body and lumbar BMD and BMC were significantly decreased in both the soy and control groups. However, there were no significant changes in total hip BMD and BMC irrespective of treatment. Both treatments positively affected markers of bone formation as indicated by increased serum bone-specific alkaline phosphatase (BSAP) activity, insulin-like growth factor-I (IGF-I), and osteocalcin (BSAP: 27.8 and 25.8%, IGF-I: 12.8 and 26.3%, osteocalcin: 95.2 and 103.4% for control and soy groups, respectively). Neither of the protein supplements had any effect on urinary deoxypyridinoline excretion, a marker of bone resorption. CONCLUSION: Our findings suggest that although one year supplementation of 25 g protein per se positively modulated markers of bone formation, this amount of protein was unable to prevent lumbar and whole body bone loss in postmenopausal women. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/15727682/One_year_soy_protein_supplementation_has_positive_effects_on_bone_formation_markers_but_not_bone_density_in_postmenopausal_women_ L2 - https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-4-8 DB - PRIME DP - Unbound Medicine ER -