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One year soy protein supplementation has positive effects on bone formation markers but not bone density in postmenopausal women.
Nutr J 2005; 4:8NJ

Abstract

BACKGROUND

Although soy protein and its isoflavones have been reported to reduce the risk of osteoporosis in peri- and post-menopausal women, most of these studies are of short duration (i.e. six months). The objective of this study was to examine if one year consumption of soy-containing foods (providing 25 g protein and 60 mg isoflavones) exerts beneficial effects on bone in postmenopausal women.

METHODS

Eighty-seven eligible postmenopausal women were randomly assigned to consume soy or control foods daily for one year. Bone mineral density (BMD) and bone mineral content (BMC) of the whole body, lumbar (L1-L4), and total hip were measured using dual energy x-ray absorptiometry at baseline and after one year. Blood and urine markers of bone metabolism were also assessed.

RESULTS AND DISCUSSION

Sixty-two subjects completed the one-year long study. Whole body and lumbar BMD and BMC were significantly decreased in both the soy and control groups. However, there were no significant changes in total hip BMD and BMC irrespective of treatment. Both treatments positively affected markers of bone formation as indicated by increased serum bone-specific alkaline phosphatase (BSAP) activity, insulin-like growth factor-I (IGF-I), and osteocalcin (BSAP: 27.8 and 25.8%, IGF-I: 12.8 and 26.3%, osteocalcin: 95.2 and 103.4% for control and soy groups, respectively). Neither of the protein supplements had any effect on urinary deoxypyridinoline excretion, a marker of bone resorption.

CONCLUSION

Our findings suggest that although one year supplementation of 25 g protein per se positively modulated markers of bone formation, this amount of protein was unable to prevent lumbar and whole body bone loss in postmenopausal women.

Authors+Show Affiliations

Department of Nutritional Sciences, Oklahoma State University, Stillwater, Oklahoma 74078, USA. arjmand@okstate.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15727682

Citation

Arjmandi, Bahram H., et al. "One Year Soy Protein Supplementation Has Positive Effects On Bone Formation Markers but Not Bone Density in Postmenopausal Women." Nutrition Journal, vol. 4, 2005, p. 8.
Arjmandi BH, Lucas EA, Khalil DA, et al. One year soy protein supplementation has positive effects on bone formation markers but not bone density in postmenopausal women. Nutr J. 2005;4:8.
Arjmandi, B. H., Lucas, E. A., Khalil, D. A., Devareddy, L., Smith, B. J., McDonald, J., ... Mason, C. (2005). One year soy protein supplementation has positive effects on bone formation markers but not bone density in postmenopausal women. Nutrition Journal, 4, p. 8.
Arjmandi BH, et al. One Year Soy Protein Supplementation Has Positive Effects On Bone Formation Markers but Not Bone Density in Postmenopausal Women. Nutr J. 2005 Feb 23;4:8. PubMed PMID: 15727682.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - One year soy protein supplementation has positive effects on bone formation markers but not bone density in postmenopausal women. AU - Arjmandi,Bahram H, AU - Lucas,Edralin A, AU - Khalil,Dania A, AU - Devareddy,Latha, AU - Smith,Brenda J, AU - McDonald,Jennifer, AU - Arquitt,Andrea B, AU - Payton,Mark E, AU - Mason,Claudia, Y1 - 2005/02/23/ PY - 2004/12/21/received PY - 2005/02/23/accepted PY - 2005/2/25/pubmed PY - 2006/7/14/medline PY - 2005/2/25/entrez SP - 8 EP - 8 JF - Nutrition journal JO - Nutr J VL - 4 N2 - BACKGROUND: Although soy protein and its isoflavones have been reported to reduce the risk of osteoporosis in peri- and post-menopausal women, most of these studies are of short duration (i.e. six months). The objective of this study was to examine if one year consumption of soy-containing foods (providing 25 g protein and 60 mg isoflavones) exerts beneficial effects on bone in postmenopausal women. METHODS: Eighty-seven eligible postmenopausal women were randomly assigned to consume soy or control foods daily for one year. Bone mineral density (BMD) and bone mineral content (BMC) of the whole body, lumbar (L1-L4), and total hip were measured using dual energy x-ray absorptiometry at baseline and after one year. Blood and urine markers of bone metabolism were also assessed. RESULTS AND DISCUSSION: Sixty-two subjects completed the one-year long study. Whole body and lumbar BMD and BMC were significantly decreased in both the soy and control groups. However, there were no significant changes in total hip BMD and BMC irrespective of treatment. Both treatments positively affected markers of bone formation as indicated by increased serum bone-specific alkaline phosphatase (BSAP) activity, insulin-like growth factor-I (IGF-I), and osteocalcin (BSAP: 27.8 and 25.8%, IGF-I: 12.8 and 26.3%, osteocalcin: 95.2 and 103.4% for control and soy groups, respectively). Neither of the protein supplements had any effect on urinary deoxypyridinoline excretion, a marker of bone resorption. CONCLUSION: Our findings suggest that although one year supplementation of 25 g protein per se positively modulated markers of bone formation, this amount of protein was unable to prevent lumbar and whole body bone loss in postmenopausal women. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/15727682/One_year_soy_protein_supplementation_has_positive_effects_on_bone_formation_markers_but_not_bone_density_in_postmenopausal_women_ L2 - https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-4-8 DB - PRIME DP - Unbound Medicine ER -