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Cardiovascular risk factors and migraine: the GEM population-based study.
Neurology 2005; 64(4):614-20Neur

Abstract

BACKGROUND

Migraine, particularly with aura, is a risk factor for early-onset ischemic stroke. The underlying mechanisms are unknown, but may in part be due to migraineurs having an increased risk profile for cardiovascular disease. In this study, the authors compare the cardiovascular risk profile of adult migraineurs to that of nonmigraineurs.

METHODS

Participants (n = 5,755, 48% men, age 20 to 65 years) are from the Genetic Epidemiology of Migraine (GEM) study, a population-based study in the Netherlands. A total of 620 current migraineurs were identified: 31% with aura (MA), 64% without aura (MO), and 5% unclassified. Controls were 5,135 individuals without lifetime migraine. Measured cardiovascular risk factors included blood pressure (BP), serum total and high-density lipoprotein cholesterol (TC, HDL), smoking, oral contraceptive use, and the Framingham risk score for myocardial infarction or coronary heart disease (CHD) death.

RESULTS

Compared to controls, migraineurs were more likely to smoke (OR = 1.43 [1.1 to 1.8]), less likely to consume alcohol (OR = 0.58 [0.5 to 0.7]), and more likely to report a parental history of early myocardial infarction. Migraineurs with aura were more likely to have an unfavorable cholesterol profile (TC > or = 240 mg/dL [OR = 1.43 (0.97 to 2.1)], TC:HDL ratio > 5.0 [OR = 1.64 (1.1 to 2.4)]), have elevated BP (systolic BP > 140 mm Hg or diastolic BP > 90 mm Hg [OR = 1.76 (1.04 to 3.0)]), and report a history of early onset CHD or stroke (OR = 3.96 [1.1 to 14.3]); female migraineurs with aura were more likely to be using oral contraceptives (OR = 2.06 [1.05 to 4.0]). The odds of having an elevated Framingham risk score for CHD were approximately doubled for the migraineurs with aura.

CONCLUSIONS

Migraineurs, particularly with aura, have a higher cardiovascular risk profile than individuals without migraine.

Authors+Show Affiliations

Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. ascher@usuhs.milNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15728281

Citation

Scher, A I., et al. "Cardiovascular Risk Factors and Migraine: the GEM Population-based Study." Neurology, vol. 64, no. 4, 2005, pp. 614-20.
Scher AI, Terwindt GM, Picavet HS, et al. Cardiovascular risk factors and migraine: the GEM population-based study. Neurology. 2005;64(4):614-20.
Scher, A. I., Terwindt, G. M., Picavet, H. S., Verschuren, W. M., Ferrari, M. D., & Launer, L. J. (2005). Cardiovascular risk factors and migraine: the GEM population-based study. Neurology, 64(4), pp. 614-20.
Scher AI, et al. Cardiovascular Risk Factors and Migraine: the GEM Population-based Study. Neurology. 2005 Feb 22;64(4):614-20. PubMed PMID: 15728281.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular risk factors and migraine: the GEM population-based study. AU - Scher,A I, AU - Terwindt,G M, AU - Picavet,H S J, AU - Verschuren,W M M, AU - Ferrari,M D, AU - Launer,L J, PY - 2005/2/25/pubmed PY - 2005/10/19/medline PY - 2005/2/25/entrez SP - 614 EP - 20 JF - Neurology JO - Neurology VL - 64 IS - 4 N2 - BACKGROUND: Migraine, particularly with aura, is a risk factor for early-onset ischemic stroke. The underlying mechanisms are unknown, but may in part be due to migraineurs having an increased risk profile for cardiovascular disease. In this study, the authors compare the cardiovascular risk profile of adult migraineurs to that of nonmigraineurs. METHODS: Participants (n = 5,755, 48% men, age 20 to 65 years) are from the Genetic Epidemiology of Migraine (GEM) study, a population-based study in the Netherlands. A total of 620 current migraineurs were identified: 31% with aura (MA), 64% without aura (MO), and 5% unclassified. Controls were 5,135 individuals without lifetime migraine. Measured cardiovascular risk factors included blood pressure (BP), serum total and high-density lipoprotein cholesterol (TC, HDL), smoking, oral contraceptive use, and the Framingham risk score for myocardial infarction or coronary heart disease (CHD) death. RESULTS: Compared to controls, migraineurs were more likely to smoke (OR = 1.43 [1.1 to 1.8]), less likely to consume alcohol (OR = 0.58 [0.5 to 0.7]), and more likely to report a parental history of early myocardial infarction. Migraineurs with aura were more likely to have an unfavorable cholesterol profile (TC > or = 240 mg/dL [OR = 1.43 (0.97 to 2.1)], TC:HDL ratio > 5.0 [OR = 1.64 (1.1 to 2.4)]), have elevated BP (systolic BP > 140 mm Hg or diastolic BP > 90 mm Hg [OR = 1.76 (1.04 to 3.0)]), and report a history of early onset CHD or stroke (OR = 3.96 [1.1 to 14.3]); female migraineurs with aura were more likely to be using oral contraceptives (OR = 2.06 [1.05 to 4.0]). The odds of having an elevated Framingham risk score for CHD were approximately doubled for the migraineurs with aura. CONCLUSIONS: Migraineurs, particularly with aura, have a higher cardiovascular risk profile than individuals without migraine. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/15728281/Cardiovascular_risk_factors_and_migraine:_the_GEM_population_based_study_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=15728281 DB - PRIME DP - Unbound Medicine ER -