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In vitro activity of ramoplanin against Clostridium difficile, including strains with reduced susceptibility to vancomycin or with resistance to metronidazole.
Antimicrob Agents Chemother. 2005 Mar; 49(3):1157-9.AA

Abstract

We evaluated the in vitro activity of ramoplanin, an antimicrobial compound that inhibits cell wall synthesis by acting at the level of lipid intermediate formation, against Clostridium difficile. We included strains with reduced susceptibilities to vancomycin (vancomycin-intermediate [Van(i)] strains) or with resistance to metronidazole (Mtz(r)), in order to assess the potential utility of ramoplanin for the treatment of C. difficile-associated diarrhea. We tested the activity of ramoplanin against a total of 105 nonduplicate clinical isolates of toxigenic C. difficile, including 8 Van(i) isolates and 6 Mtz(r) isolates, obtained from our laboratory. Ramoplanin was active against all strains tested at concentrations ranging from 0.03 to 0.5 microg/ml (MICs at which 50 and 90% of isolates were inhibited, 0.25 microg/ml; geometric mean MIC, 0.22 microg/ml). All isolates, independently of their levels of susceptibility to vancomycin or metronidazole, were considered susceptible to ramoplanin (MICs, < or =0.5 microg/ml).

Authors+Show Affiliations

Deparment of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, C/ Dr. Esquerdo 46, 28007, Madrid, Spain. terepelaez@teleline.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15728918

Citation

Peláez, T, et al. "In Vitro Activity of Ramoplanin Against Clostridium Difficile, Including Strains With Reduced Susceptibility to Vancomycin or With Resistance to Metronidazole." Antimicrobial Agents and Chemotherapy, vol. 49, no. 3, 2005, pp. 1157-9.
Peláez T, Alcalá L, Alonso R, et al. In vitro activity of ramoplanin against Clostridium difficile, including strains with reduced susceptibility to vancomycin or with resistance to metronidazole. Antimicrob Agents Chemother. 2005;49(3):1157-9.
Peláez, T., Alcalá, L., Alonso, R., Martín-López, A., García-Arias, V., Marín, M., & Bouza, E. (2005). In vitro activity of ramoplanin against Clostridium difficile, including strains with reduced susceptibility to vancomycin or with resistance to metronidazole. Antimicrobial Agents and Chemotherapy, 49(3), 1157-9.
Peláez T, et al. In Vitro Activity of Ramoplanin Against Clostridium Difficile, Including Strains With Reduced Susceptibility to Vancomycin or With Resistance to Metronidazole. Antimicrob Agents Chemother. 2005;49(3):1157-9. PubMed PMID: 15728918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro activity of ramoplanin against Clostridium difficile, including strains with reduced susceptibility to vancomycin or with resistance to metronidazole. AU - Peláez,T, AU - Alcalá,L, AU - Alonso,R, AU - Martín-López,A, AU - García-Arias,V, AU - Marín,M, AU - Bouza,E, PY - 2005/2/25/pubmed PY - 2005/5/10/medline PY - 2005/2/25/entrez SP - 1157 EP - 9 JF - Antimicrobial agents and chemotherapy JO - Antimicrob. Agents Chemother. VL - 49 IS - 3 N2 - We evaluated the in vitro activity of ramoplanin, an antimicrobial compound that inhibits cell wall synthesis by acting at the level of lipid intermediate formation, against Clostridium difficile. We included strains with reduced susceptibilities to vancomycin (vancomycin-intermediate [Van(i)] strains) or with resistance to metronidazole (Mtz(r)), in order to assess the potential utility of ramoplanin for the treatment of C. difficile-associated diarrhea. We tested the activity of ramoplanin against a total of 105 nonduplicate clinical isolates of toxigenic C. difficile, including 8 Van(i) isolates and 6 Mtz(r) isolates, obtained from our laboratory. Ramoplanin was active against all strains tested at concentrations ranging from 0.03 to 0.5 microg/ml (MICs at which 50 and 90% of isolates were inhibited, 0.25 microg/ml; geometric mean MIC, 0.22 microg/ml). All isolates, independently of their levels of susceptibility to vancomycin or metronidazole, were considered susceptible to ramoplanin (MICs, < or =0.5 microg/ml). SN - 0066-4804 UR - https://www.unboundmedicine.com/medline/citation/15728918/In_vitro_activity_of_ramoplanin_against_Clostridium_difficile_including_strains_with_reduced_susceptibility_to_vancomycin_or_with_resistance_to_metronidazole_ L2 - http://aac.asm.org/cgi/pmidlookup?view=long&amp;pmid=15728918 DB - PRIME DP - Unbound Medicine ER -